Results 21 to 30 of about 2,191 (109)

COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS

Pakistan Armed Forces Medical Journal, 2021
Objective: To compare the efficacy of oral chloroquine with systemic meglumine antimoniate in treatment of cutaneous leishmaniasis. Study Design: Open-label comparative prospective study.
Muhammad Farooq, Muhammad Saad Farooq, Arfan Ul Bari, Tariq Mehmood Malik   +3 more
doaj   +1 more source

Study of the in vitro and in vivo antileishmanial activities of nimodipine in susceptible BALB/c mice

Journal of Vector Borne Diseases, 2020
Background & objectives: Pentavalent antimonials are the standard treatment for cutaneous leishmaniasis (CL), however, treatment failures are frequent. Nimodipine, a calcium channel blocker is known to show promising antiprotozoal effects.
Reza Azadi, Ghazal Alipour-Talesh, Mohammad Javad Yazdanpanah, Seyedeh Hoda Alavizadeh, Masoud Maleki, Mahnaz Banihashemi, Mahmoud Reza Jaafari   +6 more
doaj   +1 more source

Comparison of Intralesional Meglumine Antimoniate Plus Oral Allopurinol with Intralesional Meglumine Antimoniate Alone for the Treatment of Cutaneous Leishmaniasis- A Prospective Study

Life and Science
Objective: To evaluate the efficacy of the combination of oral allopurinol plus intralesional meglumine for the treatment of Cutaneous Leishmaniasis. Study Design: A prospective study.
Nida Qayyum, Perisa Gul, Aleena Zainab, Maryam Jawaid, Muhammad Azam, Sana Sattar   +5 more
doaj   +1 more source

Ex vivo host and parasite response to antileishmanial drugs and immunomodulators. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Therapeutic response in infectious disease involves host as well as microbial determinants. Because the immune and inflammatory response to Leishmania (Viannia) species defines the outcome of infection and efficacy of treatment ...
Laura Gonzalez-Fajardo, Olga Lucía Fernández, Diane McMahon-Pratt, Nancy Gore Saravia   +3 more
doaj   +1 more source

Intralesional treatment with meglumine antimoniate in three patients with New World cutaneous leishmaniasis and large periarticular lesions with comorbidities

Revista da Sociedade Brasileira de Medicina Tropical
Although New World cutaneous leishmaniasis is not itself a life-threatening disease, its treatment with systemic antimonials can cause toxicity that can be dangerous to some patients.
Maria Inês Fernandes Pimentel, Érica de Camargo Ferreira e Vasconcellos, Carla de Oliveira Ribeiro, Marcelo Rosandiski Lyra, Mauricio Naoto Saheki, Mariza de Matos Salgueiro, Liliane de Fátima Antonio, Armando de Oliveira Schubach   +7 more
doaj   +1 more source

Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2′-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment

Molecules, 2018
Epoxymethoxylawsone is a naphthoquinone derivative promising as drug candidate for the treatment of leishmaniases. In the present work the effectiveness of epoxymethoxylawsone, and meglumine antimoniate on Leishmania (Leishmania) amazonensis parasites ...
Luiz Filipe Gonçalves Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Lea Cysne-Finkelstein, Mirian Cláudia de Souza Pereira, Francisco Odêncio de Oliveira Junior, Rosa Teixeira Pinho, Suzana Corte Real, Saulo Cabral Bourguignon, Vitor Francisco Ferreira, Carlos Roberto Alves   +10 more
doaj   +1 more source

Comparison of in vitro Resistance of Wild Leishmania İsolates, Which are Resistant to Pentavalent Antimonial Compounds, Against Drugs Used in the Treatment of Leishmaniasis

Türkiye Parazitoloji Dergisi, 2020
Objective:Meglumine antimoniate (Glucantime®) and Sodium stibogluconate (Pentostam®) are used for the treatment of cutaneous leismaniasis in Turkey. There is a reported resistance to these drugs in recent years.
Ahmet Özbilgin, İbrahim Çavuş, Tuğba Kaya, Ahmet Yıldırım, Mehmet Harman   +4 more
doaj   +1 more source

Use of GnRH Agonist in Dogs Affected with Leishmaniosis

Animals, 2021
Sex-associated hormones such as testosterone have been demonstrated to modulate immune responses, which can result in different disease outcomes. The present study was aimed at evaluating the efficacy of a gonadotropin-releasing hormone GnRH agonist ...
Michela Pugliese, Vito Biondi, Marco Quartuccio, Santo Cristarella, Giovanni Emmanuele, Gabriele Marino, Luigi Liotta, Annamaria Passantino   +7 more
doaj   +1 more source

An Unusual Presentation of Cutaneous Leishmaniasis in a Patient with Substance Use: A Diagnostic and Management Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT In patients with atypical ulcers and travel history to endemic areas, a comprehensive diagnostic workup for cutaneous leishmaniasis is imperative. This case confirms Leishmania tropica through combined microscopy, culture, and PCR, leading to successful treatment with systemic glucantime and adjunctive wound care.
Hossein Pazoki, Eissa Soleymani, Shirafkan Kordi, Mahdi Fakhar   +3 more
wiley   +1 more source

Good response to pentamidine isethionate in a case of Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis that was difficult to treat: Case Report

Revista da Sociedade Brasileira de Medicina Tropical, 2019
In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate.
Benivaldo Ramos Ferreira Terceiro, Tania Salgado de Souza Torraca, Frederico Pereira Bom Braga, Ana Cristina da Costa Martins, Lucia Regina Brahim, Mauricio Naoto Saheki, Luciana de Freitas Campos Miranda, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino   +8 more
doaj   +1 more source