FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 2014 Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular ...
Cláudia Maria Valete-Rosalino +12 more
doaj +4 more sources
Novel methods for the encapsulation of meglumine antimoniate into liposomes [PDF]
Brazilian Journal of Medical and Biological Research, 2000 The antimonial drug, meglumine antimoniate, was successfully encapsulated in dehydration-rehydration vesicles and in freeze-dried empty liposomes (FDELs).
F. Frézard +3 more
doaj +4 more sources
Plasma antimony determination during cutaneous leishmaniasis treatment with intralesional infiltration of meglumine antimoniate [PDF]
Tropical Medicine & International Health, 2018 AbstractObjectivesTo evaluate the antimony (Sb) in plasma of patients who underwent a standardised meglumine antimoniate (MA) intralesional infiltration protocol for cutaneous leishmaniasis treatment.MethodsThe level of Sb in plasma was determined by atomic absorption spectroscopy, before and 1, 2, 4 and 6 hours after the first intralesional ...
Marta Gontijo, de Aguiar +5 more
openaire +4 more sources
Speciation of antimony (III) and antimony (V) using hydride generation for meglumine antimoniate pharmaceutical formulationsquality control [PDF]
Memorias do Instituto Oswaldo Cruz, 2008 The pentavalent antimonies, mainly the meglumine antimoniate, are recommends as first-choice medicines for leishmaniasis therapy. In this work we described the development of formulations of meglumine antimoniate injectable medication, as well as the ...
Lúcio Mendes Cabral +7 more
doaj +4 more sources
Standardization of intralesional meglumine antimoniate treatment for cutaneous leishmaniasis [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2016 INTRODUCTION: Intralesional treatment for cutaneous leishmaniasis has been applied for over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity. METHODS Meglumine antimoniate was
Maria Cristina de Oliveira Duque +7 more
doaj +3 more sources
Parasites & Vectors, 2015 Background Visceral leishmaniosis is a potentially life-threatening illness caused by a protozoan parasite of the genus Leishmania. It is found mainly in areas where both the parasite and its vector are endemic and is one of the most challenging ...
Laura Manna +5 more
doaj +2 more sources
Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]
, 2020 This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel +6 more
core +1 more source
Efficacy of Spironolactone Treatment in Murine Models of Cutaneous and Visceral Leishmaniasis
Frontiers in Pharmacology, 2021 Translational studies involving the reuse and association of drugs are approaches that can result in higher success rates in the discovery and development of drugs for serious public health problems, including leishmaniasis.
Valter Viana Andrade-Neto +7 more
doaj +1 more source
Glutathione-Induced Conversion of Pentavalent Antimony to Trivalent Antimony in Meglumine Antimoniate [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT The standard treatment of human leishmaniases involves the use of pentavalent antimony [Sb(V)] compounds, including meglumine antimoniate. The mode of action of these compounds has not been fully elucidated. The possibility that Sb(III) is involved has been suggested; however, the biomolecule that may induce the ...
F, Frézard +3 more
openaire +2 more sources
Embryonic toxico-pathological effects of meglumine antimoniate using a chick embryo model. [PDF]
PLoS ONE, 2018 Leishmaniasis is one of the diverse and neglected tropical diseases. Embryo-toxicity of drugs has always been a major concern. Chick embryo is a preclinical model relevant in the assessment of adverse effects of drugs.
Ahmad Khosravi +7 more
doaj +1 more source