Results 61 to 70 of about 5,890 (202)

Increased Leishmania infantum resistance to miltefosine and amphotericin B after treatment of a dog with miltefosine and allopurinol

Parasites & Vectors, 2021
Background Leishmania infantum is the most important etiological agent of visceral leishmaniasis in the Americas and Mediterranean region, and the dog is the main host.
Gustavo Gonçalves, Monique Paiva Campos, Alessandra Silva Gonçalves, Lia Carolina Soares Medeiros, Fabiano Borges Figueiredo   +4 more
doaj   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Chemical Constituents and Biological Activities of Oxandra (Annonaceae): A Review

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Oxandra (Annonaceae) comprises 29 species distributed across South and Central America. Despite this diversity, the genus remains under‐investigated. This study presents the first comprehensive review of the chemical composition and biological activities of Oxandra species, utilizing databases such as SciFinder, ScienceDirect, PubMed, and ...
Rayssa Cota Lopes, Francisco Paiva Machado, Mateus de Freitas Brito, Thalisson Amorim de Souza, Lucas Silva Abreu   +4 more
wiley   +1 more source

Coinfection of Leprosy and American Cutaneous Leishmaniasis: A Case Report From Ceará, Brazil

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
Leprosy and American cutaneous leishmaniasis are endemic diseases in Brazil that may coexist in the same host, particularly in coendemic regions. We report the case of a 68‐year‐old woman presenting with a six‐month history of an ulcerated lesion on the left knee and concomitant disseminated annular plaques associated with sensory loss, madarosis, and ...
Moacir Pereira Leite Neto, Jordannia Oliveira Fernandes, Ana Carolina Carvalho Ferraz, Julia Graziele Alves Marelli, Marcos Antônio Pereira de Lima, Cláudio Gleidiston Lima da Silva, Ligia Regina Franco Sansigolo Kerr, Ricardo Queiroz Gurgel, Semonti Nandi   +8 more
wiley   +1 more source

Relative mRNA expression levels of VEGF-A and VEGF-R2 genes following meglumine antimoniate treatment.

, 2018
The expression of VEGF-A and VEGF-R2 mRNA in the chick extra-embryonic membranes (n = 4 per experimental group) decreased in the meglumine antimoniate-treated groups as compared to the controls.
Amin Derakhshanfar (5285756), Ahmad Khosravi (525161), Mehdi Bamorovat (4836909), Hadi Tavakkoli (5285762), Zohreh Salari (5285765), Seyedeh Saedeh Mosallanejad (5285753), Iraj Sharifi (344800), Ali Reza Keyhani (5285759)   +7 more
core   +1 more source

Relapsing Nasal Septal Leishmaniasis: Lessons in Long‐Term Multidisciplinary Management Case Report

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Introduction Mucosal leishmaniasis (ML) is a rare, destructive, and recurrent protozoal infection caused by Leishmania species, most commonly Leishmania braziliensis. ML can develop months to years after initial cutaneous leishmaniasis (CL) and may lead to severe mucosal destruction if untreated.
Emily Ehsan, Ellie Staab, Katie Geelan-Hansen, Richard Hankins, Priya Gusain   +4 more
wiley   +1 more source

The efficacy of combined topical niosomal dapsone gel and intralesional injection of meglumine antimoniate in comparison with intralesional meglumine antimoniate and cryotherapy in the treatment of cutaneous leishmaniasis

, 2017
Objective To evaluate the efficacy of niosomal dapsone gel and intralesional meglumine antimoniate with cryotherapy and intralesional meglumine antimoniate in cutaneous leishmaniasis. Methods This was a randomized clinical trial with 73 participants that
Mahin Aflatoonian, Payam Khazaeli, Alireza Fekri, Kambiz Bahadini, Maryam Khalili, Zahra Rahnam, Abbas Pardakhti   +6 more
core   +1 more source

Efficacy Of Intralesional Ciprofloxacin In Cutaneous Leishmaniasis As Compared To Intralesional Meglumine Antimoniate [PDF]

Objective: Cutaneous leishmaniasis (CL), a neglected tropical disease, poses a significant therapeutic challenge in endemic regions. Although intralesional meglumine antimoniate (MA) remains a standard treatment, its drawbacks necessitate the exploration
Zafar, Humna, Rehman, Naila, Yasmin, Ghazala, Nawaz, Faiz ul Hassan, Kausar, Sameena, Mazhar, Hina   +5 more
core   +1 more source

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source

American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure [PDF]

Anais Brasileiros de Dermatologia, 2019
: Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months.
Sílvio Alencar Marques, Maira Renata Merlotto, Paulo Müller Ramos, Mariangela Esther Alencar Marques   +3 more
doaj   +1 more source