Results 61 to 70 of about 4,754 (217)

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids [PDF]

, 2017
We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids.
Elisa García, Iván D. Vélez, Juan C. Coa, July A. Muñoz, Lina M. Yepes, Miguel Carda, Raúl Agut, Sara M. Robledo, Wilson I. Cardona   +8 more
core   +2 more sources

Chemical Constituents and Biological Activities of Oxandra (Annonaceae): A Review

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Oxandra (Annonaceae) comprises 29 species distributed across South and Central America. Despite this diversity, the genus remains under‐investigated. This study presents the first comprehensive review of the chemical composition and biological activities of Oxandra species, utilizing databases such as SciFinder, ScienceDirect, PubMed, and ...
Rayssa Cota Lopes, Francisco Paiva Machado, Mateus de Freitas Brito, Thalisson Amorim de Souza, Lucas Silva Abreu   +4 more
wiley   +1 more source

Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis

Stem Cell Research & Therapy, 2020
Background Leishmaniasis is a neglected disease caused by Leishmania spp. One of its characteristics is an imbalance of host immune responses to foster parasite survival.
Tadeu Diniz Ramos, Johnatas Dutra Silva, Alessandra Marcia da Fonseca-Martins, Juliana Elena da Silveira Pratti, Luan Firmino-Cruz, Diogo Maciel-Oliveira, Julio Souza Dos-Santos, João Ivo Nunes Tenorio, Almair Ferreira de Araujo, Célio Geraldo Freire-de-Lima, Bruno Lourenço Diaz, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Herbert Leonel de Matos Guedes   +13 more
doaj   +1 more source

Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate [PDF]

Memórias do Instituto Oswaldo Cruz, 2014
Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics.
Coelho, Deise Riba, Miranda, Elaine Silva, Saint?Pierre, Tatiana Dillenburg, Paumgartten, Francisco José Roma   +3 more
openaire   +4 more sources

Leishmaniasis in Morocco: Epidemiology, Transmission Dynamics, and the Potential of Artificial Intelligence for Disease Management

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Leishmaniases are neglected tropical diseases caused by Leishmania parasites and transmitted by infected phlebotomine sand flies, and they remain a major public health challenge in Morocco. The burden is dominated by cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL), mainly associated with Leishmania major, Leishmania tropica, and L ...
Chaymaa Harkat, Denis Sereno, Abdelmohcine Aimrane, Moulay Abdelmonaim Hidan, Mohamed Yamani, Kholoud Kahime, J.M.P. Barçante   +6 more
wiley   +1 more source

Leishmania RNA Virus and Its Impact on Drug Response and Clinical Outcomes in Leishmaniasis: A Comprehensive Review

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Leishmania RNA viruses (LRVs) have emerged as significant modulators of disease severity, therapeutic response, and clinical outcomes in various forms of leishmaniasis. This review provides a comprehensive overview of the current knowledge surrounding LRV1 and LRV2, focusing on their taxonomy, molecular biology, epidemiological patterns, and pathogenic
Azadeh Zolfaghari, Sarah Seyedyousefi, Zabihollah Shahmoradi, Erfan Zaker, Bahman Rahimi Esboei, Amit Prasad   +5 more
wiley   +1 more source

Increased Leishmania infantum resistance to miltefosine and amphotericin B after treatment of a dog with miltefosine and allopurinol

Parasites & Vectors, 2021
Background Leishmania infantum is the most important etiological agent of visceral leishmaniasis in the Americas and Mediterranean region, and the dog is the main host.
Gustavo Gonçalves, Monique Paiva Campos, Alessandra Silva Gonçalves, Lia Carolina Soares Medeiros, Fabiano Borges Figueiredo   +4 more
doaj   +1 more source

Topical Application of Imiquimod as a Treatment for Chromoblastomycosis [PDF]

, 2014
Peer reviewedPublisher ...
Belda Junior, Walter, Benard, Gil, Brown, Gordon D., Criado, Paulo Ricardo, Lota, Priscila Ramos, Sousa, Maria Da Gloria, Spina, Ricardo, Valente, Neusa Sakai   +7 more
core   +1 more source

Systemic Meglumine Antimoniate in Acute Cutaneous Leishmaniasis: Children versus Adults [PDF]

The American Society of Tropical Medicine and Hygiene, 2011
Some studies showed that children have a lower response to systemic use of pentavalent antimoniate than adults. We aimed to evaluate the response rate to Glucantime therapy in children and compare it with adults. One hundred and twelve patients with acute cutaneous leishmaniais (ACL) were divided into two equal groups of adults (> 15 yrs) and ...
Pouran, Layegh, Sara, Rahsepar, Amir Ali, Rahsepar   +2 more
openaire   +2 more sources