Results 11 to 20 of about 2,542 (193)
Comprehensive lipid analysis of human meibum and tears [PDF]
Scientific ReportsAbnormalities in the tear film lipid layer, which plays a critical role in preventing water evaporation and protecting the corneal surface, lead to dry eye disease.
Makiko Terai +3 more
doaj +5 more sources
Lipid composition of human meibum [PDF]
African Vision and Eye Health, 2013 The structure and function of meibomian gland lipids in the tear film are highly complex. Evidence shows that the precorneal tear film consists of discrete layers: the inner mucin layer, the middle aqueous layer and the outer lipid layer.
R. Schnetler +2 more
doaj +4 more sources
A Comparison of Patient Matched Meibum and Tear Lipidomes [PDF]
Investigative Opthalmology & Visual Science, 2013 To quantify the molecular lipid composition of patient-matched tear and meibum samples and compare tear and meibum lipid molecular profiles.Lipids were extracted from tears and meibum by bi-phasic methods using 10:3 tert-butyl methyl ether:methanol, washed with aqueous ammonium acetate, and analyzed by chip-based nanoelectrospray ionization tandem mass
Brown, Simon +9 more
core +5 more sources
The Ocular Surface, 2022 Sphingolipids (SPL) play a role in cell signaling, inflammation, and apoptosis. The purpose of this study was to examine meibum and tear SPL composition in individuals with poor versus good meibum quality.Individuals were grouped by meibum quality (n = 25 with poor quality, case group and n = 25 with good quality, control group).
Anat Galor +7 more
openaire +3 more sources
Spectroscopic measurements of meibum compositional, structural, and functional relationships to elucidate the role of meibum in dry eye. [PDF]
, 2022 The major aim of my dissertation was to investigate the etiology of dry eye disease which affects about 7 million people in the United States, causing symptoms that can lead to visual disturbance.
Ewurum, Anthony Chigozie
openaire +2 more sources
Meibum lipid composition in Asians with dry eye disease. [PDF]
PLoS ONE, 2011 Previous lipidomic analyses of the human meibum had largely focused on individuals from non-Asian populations, despite the higher prevalence of dysfunctional tear syndrome (DTS) observed across Asia.
Sin Man Lam +6 more
doaj +4 more sources
Applied Sciences, 2022 Meibomian gland disease is associated with quantitative or qualitative deficiencies of meibum (MGS) that result in tear film instability. Thus, there is great demand for ophthalmic nanoemulsions that can replenish MGS and recover its performance at the ...
Petar Eftimov +4 more
doaj +2 more sources
Meibum Lipidomic Analysis in Evaporative Dry Eye Subjects [PDF]
International Journal of Molecular SciencesMeibomian Glands (MG) are sebaceous glands responsible for the production of meibum, the main component of the Tear Film Lipid Layer (TFLL). The TFLL facilitates the spread of the tear film over the ocular surface, provides stability and reduces tear evaporation.
Jacobo Garcia-Queiruga +7 more
openaire +4 more sources
Deep Cleaning Device as a Treatment Is Effective for Blepharitis and Significantly Reduces Bacterial Load. [PDF]
J OphthalmolObjective To evaluate the efficacy and safety of the Deep Cleaning Device for the treatment of blepharitis. Methods This prospective, randomized controlled trial enrolled 51 adult patients with blepharitis, who were randomly allocated to two treatment groups.
Wen Y +6 more
europepmc +2 more sources
American journal of ophthalmology, 2022 To determine the relationship between tear film interferometric patterns and properties of lipid, including rheological properties.Prospective, cross-sectional laboratory investigation.This study included 105 subjects (94 dry eye patients and 11 normal participants). The subjects were divided into 3 categories (group 1, normal; group 2, thin; and group
Ikhyun, Jun +7 more
openaire +3 more sources