Results 51 to 60 of about 2,542 (193)

Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry

Journal of Lipid Research, 2019
Secretions from meibomian glands located within the eyelid (commonly known as meibum) are rich in nonpolar lipid classes incorporating very-long (22–30 carbons) and ultra-long (>30 carbons) acyl chains.
Sarah E. Hancock, Berwyck L.J. Poad, Mark D.P. Willcox, Stephen J. Blanksby, Todd W. Mitchell   +4 more
doaj   +1 more source

Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids

Journal of Lipid Research, 2018
The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are structurally related to the general class of FA esters of hydroxy FAs (FAHFAs), the ultra-long ...
Sarah E. Hancock, Ramesh Ailuri, David L. Marshall, SimonH.J. Brown, Jennifer T. Saville, Venkateswara R. Narreddula, Nathan R. Boase, BerwyckL.J. Poad, Adam J. Trevitt, MarkD.P. Willcox, Michael J. Kelso, Todd W. Mitchell, Stephen J. Blanksby   +12 more
doaj   +1 more source

Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction

Current Issues in Molecular Biology, 2023
Meibomian gland dysfunction (MGD) is a functional and morphological disorder of the meibomian glands which results in qualitative or quantitative alteration in meibum secretion and is the major cause of evaporative dry eye (EDE).
Ya-Li Du, Xi Peng, Yang Liu, Jia-Song Wang, You-Fan Ye, Kang-Kang Xu, Jing-Yu Qu, Hua Chen, Hua-Tao Xie, Ming-Chang Zhang   +9 more
doaj   +1 more source

Observation of Influence of Cataract Surgery on the Ocular Surface. [PDF]

PLoS ONE, 2016
INTRODUCTION:To evaluate meibomian gland function, changes of lacrimal tears and ocular surface parameters and tear inflammatory mediators following cataract surgery.
Yuli Park, Hyung Bin Hwang, Hyun Seung Kim   +2 more
doaj   +1 more source

Lipidomics Profiles Revealed Alterations in Patients With Meibomian Gland Dysfunction After Exposure to Intense Pulsed Light

Frontiers in Neurology, 2022
So far, intense pulsed light (IPL) has been widely used in the treatment of meibomian gland dysfunction (MGD), but there was still a lack of research on its specific mechanism.
Hui Zhao, Shi-Nan Wu, Yi Shao, Dong Xiao, Li-Ying Tang, Zhe Cheng, Jie Peng   +6 more
doaj   +1 more source

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and meta‐analysis evaluated the efficacy of low‐level light therapy (LLLT) as a ...
Sjur Reppe, Yousif Subhi, Tore Steinkjer, Mazyar Yazdani, Miriam Kolko, Tor P. Utheim, Fredrik Andreas Fineide   +6 more
wiley   +1 more source

Temperature-Induced Transitions in the Structure and Interfacial Rheology of Human Meibum [PDF]

Biophysical Journal, 2012
Meibomian lipids are the primary component of the lipid layer of the tear film. Composed primarily of a mixture of lipids, meibum exhibits a range of melt temperatures. Compositional changes that occur with disease may alter the temperature at which meibum melts.
Danielle, Leiske, Danielle L, Leiske, Christopher, Leiske, Christopher I, Leiske, Daniel, Leiske, Daniel R, Leiske, Michael, Toney, Michael F, Toney, Michelle, Senchyna, Howard, Ketelson, Howard A, Ketelson, David, Meadows, David L, Meadows, Gerald G, Fuller   +13 more
openaire   +4 more sources

Lipid order, saturation and surface property relationships : a study of human meibum saturation

, 2013
Tear film stability decreases with age however the cause(s) of the instability are speculative. Perhaps the more saturated meibum from infants may contribute to tear film stability.
Bhola, Rahul, Yappert, Marta C., Cox, Gregory W., Whitehall, John (R15925), Smith, Ryan J., Borchman, Douglas, Duran, Diana, Mudgil, Poonam (R10383), Dennis, Gary R. (R7569)   +8 more
core   +1 more source

Assessment of Eyelid Pressure Using a Novel Pressure Measurement Device in Patients With Moderate-to-Severe Dry Eye Disease

Frontiers in Medicine, 2022
ObjectiveTo assess a novel eyelid pressure measurement device and study the relationship between eyelid pressure and ocular surface parameters of moderate-to-severe dry eye disease (DED).MethodsThe present study included 70 eyes of 35 moderate-to-severe ...
Jingyi Wang, Jiayu Bao, Wenxiu Song, Siyuan Li, Yiran Hao, Lei Tian, Lei Tian, Ying Jie   +7 more
doaj   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source