Results 41 to 50 of about 17,124 (228)

Seed ageing and meiotic chromosomal abnormalities in lettuce.

CYTOLOGIA, 1989
Meiotic chromosomal abnormalities observed in lettuce plants grown from aged seeds increased with the decrease in the viability of the seed lot. Univalents, fragments and a few cases of precocious segregation were observed in metaphase I. Abnormalities found at anaphase I and anaphase II included dicentric bridges with or without fragments, acentric ...
Rao, N. K., Roberts, E. H.
openaire   +2 more sources

Four Loci on Abnormal Chromosome 10 Contribute to Meiotic Drive in Maize [PDF]

Genetics, 2003
Abstract We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic drive, each providing distinct functions that can be ...
Evelyn N, Hiatt, R Kelly, Dawe
openaire   +2 more sources

Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. [PDF]

PLoS Genetics, 2013
The RAD9-RAD1-HUS1 (9-1-1) complex is a heterotrimeric PCNA-like clamp that responds to DNA damage in somatic cells by promoting DNA repair as well as ATR-dependent DNA damage checkpoint signaling.
Amy M Lyndaker, Pei Xin Lim, Joanna M Mleczko, Catherine E Diggins, J Kim Holloway, Rebecca J Holmes, Rui Kan, Donald H Schlafer, Raimundo Freire, Paula E Cohen, Robert S Weiss   +10 more
doaj   +1 more source

Melatonin Protects Against Mdivi-1-Induced Abnormal Spindle Assembly and Mitochondrial Superoxide Production During Porcine Oocyte Maturation

Frontiers in Cell and Developmental Biology, 2021
Mitochondrial division inhibitor 1 (Mdivi-1) reportedly provides a close connection between oocyte maturation and mitochondrial function in pigs. N-acetyl-5-methoxy-tryptamine (melatonin) is known to be a representative antioxidant with the ability to ...
Seul-Gi Yang, Seul-Gi Yang, Seung-Yeon Joe, Seung-Yeon Joe, Jin-Wook Bae, Jin-Wook Bae, Gyeong-Deok Heo, Gyeong-Deok Heo, Hyo-Jin Park, Hyo-Jin Park, Deog-Bon Koo, Deog-Bon Koo   +11 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Meiotic behavior and its implications on the reproductive success of Arnebia euchroma (Royle ex Benth.) I.M.Johnst. (Boraginaceae), an important medicinal plant of Trans-Himalaya

Caryologia
The present study reports the chromosome number, meiotic behavior and its relation with pollen fertility and seed set of Arnebia euchroma (Royle ex Benth.) I.M.Johnst. The species shows a chromosome count of 2n = 2x = 14.
Irfan Iqbal Sofi, Shivali Verma, Aijaz H. Ganie, Namrata Sharma, Manzoor A. Shah   +4 more
doaj   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Meiotic abnormalities in patients bearing complete AZFc deletion of Y chromosome [PDF]

Human Reproduction, 2007
We studied meiosis in three infertile patients presenting complete AZFc microdeletion and three controls.Primary spermatocytes were immunolabeled with SCP3, BRCA1 and gammaH2AX. We quantified the leptotene, zygotene and pachytene stages, and pachytene abnormalities: asynapsis and fragmented and dotted synaptonemal complexes (SCs).SCP3 level was ...
C, Geoffroy-Siraudin, I, Aknin-Seiffer, C, Metzler-Guillemain, R, Ghalamoun-Slaimi, M F, Bonzi, R, Levy, M R, Guichaoua   +6 more
openaire   +2 more sources

The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. [PDF]

, 2009
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR).
Yamauchi, Yasuhiro, Julie Cocquet, Nabeel A Affara, Burgoyne, Paul S., Yasuhiro Yamauchi, Cocquet, Julie, Affara, Nabeel A., Mahadevaiah, Shantha K., Ellis, Peter J.I., Peter J I Ellis, Monika A Ward, Shantha K Mahadevaiah, Ward, Monika A., Paul S Burgoyne   +13 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source