Results 191 to 200 of about 133,463 (299)

BRAF; MEK [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

4′‐Hydroxywogonin Attenuates Hepatocellular Carcinoma Progression by Suppressing Gas6/Axl‐PI3K/AKT Signaling

Phytotherapy Research, EarlyView.
4′‐Hydroxywogonin, a flavonoid derived from Scutellaria baicalensis, inhibits hepatocellular carcinoma progression partly by suppressing Gas6/Axl‐PI3K/AKT signaling, inducing cell cycle arrest and apoptosis, and reducing metastatic potential. It also suppresses xenograft tumor growth without evident hepatotoxicity.
Chi‐Yuan Chen, Chin‐Chuan Chen, Chau‐Ting Yeh, Chieh‐Wen Chan, Yu‐De Chu, Yann‐Lii Leu, Roshan B. Satange, Li‐Fang Chou, Wen‐Yu Chuang, Chuen Hsueh, Tzong‐Ming Shieh, Tong‐Hong Wang   +11 more
wiley   +1 more source

From Innovation to Sustainability: Integrating Fintech, Green Trade and Knowledge Systems for Circular Growth in Sub‐Saharan Africa

Sustainable Development, EarlyView.
ABSTRACT The transition toward circular and sustainable growth remains a major challenge in Sub‐Saharan Africa (SSA), where resource constraints, limited recycling capacity, and infrastructure deficits constrain environmental performance. Drawing on circular economy and innovation systems perspectives, this study examines how financial technology ...
Emmanuel Kwaku Manu, Bismark Asante, Maria L. Gorbunova, Isaiah Nketiah   +3 more
wiley   +1 more source

TEAD inhibitors re-sensitize drug-resistant NF1 MPNST cells to MEK inhibitors. [PDF]

MicroPubl Biol
Yang Y, Guo J, Gurunathan S, Schechter S, Field J.   +4 more
europepmc   +1 more source

Population Pressures, Institutional Quality and Environmental Sustainability in Sub‐Saharan Africa: Nonlinear Dynamics and Regional Heterogeneity

Sustainable Development, EarlyView.
ABSTRACT Rapid population growth, environmental degradation and institutional constraints continue to shape environmental sustainability in Sub‐Saharan Africa (SSA), yet evidence on nonlinear demographic dynamics, governance moderation and regional differences remains limited.
Emmanuel K. Manu
wiley   +1 more source

Precision Medicine in Dermatology: MEK Inhibition and MAPK Pathway Modulation for Congenital Melanocytic Nevi. [PDF]

Biomedicines
Forsyth A, Imokhai OP, Fure K, do Valle R, Ayoub R, Sataray-Rodriguez A, Martinez G, Brooks A.   +7 more
europepmc   +1 more source

Refinement of MEK inhibitors

Future Medicinal Chemistry
Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Amita Verma, Pradeep Kumar   +4 more
openaire   +2 more sources

Global Attention and Mobility‐Enabled Knowledge: How Intermediate Units Gain Strategic Visibility in Multinational Corporations

Thunderbird International Business Review, EarlyView.
ABSTRACT This study examines how Intermediate Units (IUs) in multinational corporations gain the attention of corporate headquarters and subsidiaries. Using the Attention‐Based View, we show that attention depends on how visible and useful the IU's knowledge appears to other internal actors.
Jose Pla‐Barber, Ana Botella‐Andreu, Andrea Pallás‐Rocafull   +2 more
wiley   +1 more source

Cytotoxic activity of selinexor in BRAF^V600E-driven pediatric low-grade glioma 3D cultures. [PDF]

Acta Neuropathol Commun
Zeiser C, Emperador M, Herter S, Sigaud L, Stroh-Dege A, Loboda A, Kolodziejczak A, Zeuner S, Digel LJ, Frese K, Chilian B, Freitas M, Kelm JM, Ǿra I, Vogl D, Schuhmann MU, Peterziel H, Sigaud R, Selt F, Milde T, Witt O, Oehme I.   +21 more
europepmc   +1 more source

Do Financialization and Innovation Enhance Environmental Sustainability in Sub‐Saharan Africa?

Thunderbird International Business Review, EarlyView.
ABSTRACT This study addresses the perception of Sub‐Saharan Africa (SSA) as a region with limited financial capabilities and technological advancement to enhance environmental sustainability. Conducted across 24 SSA countries from 2000 to 2021, the research employs instrumental IV and panel quantile regressions.
Emmanuel Kwaku Manu, Maria L. Gorbunova, Simplice A. Asongu   +2 more
wiley   +1 more source