Results 201 to 210 of about 133,463 (299)

Reduced IQGAP2 promotes esophageal squamous cell carcinoma by regulating MEK/ERK MAPK pathway. [PDF]

Front Genet
Zhao L.
europepmc   +1 more source

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source

Targeting MAPK Pathways in Skin, Thyroid, and Pancreatic Cancer: A Perspective on Synthetic Inhibitors and Natural Modulators. [PDF]

Adv Biol (Weinh)
Wasnik D, Swamy KV, Vyas R.
europepmc   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

The PD-L1-mTOR intersection in tumor migration and invasion. [PDF]

Mol Biol Rep
Palavro R, Previato TTR, Pazzin DB, Gonçalves JB, Boff MO, Marinowic D, da Costa JC, Scheffel TB.   +7 more
europepmc   +1 more source

Interobserver Variability in Intraoperative Classification of Acute Appendicitis and Postoperative Antibiotic Management

World Journal of Surgery, EarlyView.
During laparoscopy for suspected acute appendicitis (AA), surgeons classify the appendix as normal, phlegmonous, gangrenous, or perforated, with or without abscess. The surgeon's assessment directly influences postoperative antibiotic treatment and length of hospitalization. There is currently no objective gold standard for this classification.
Miranda Elisabeth Krusmynta Ocklind, Kathrine Holte, Niels Henrik Bruun, Rasmus Virenfeldt Flak   +3 more
wiley   +1 more source

Tunlametinib Suppresses Melanogenesis Induces Cell Cycle Arrest and Apoptosis in Giant Congenital Melanocytic Nevus Cells. [PDF]

Cancers (Basel)
Guan JY, Chen Z, Liu WS, Xu JL, Zhou ZY, Song L, Deng D.   +6 more
europepmc   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Unveiling BRAF Mutations in Non-small Cell Lung Cancer: State of the Art and Future Perspectives. [PDF]

Lung
Colombino M, Paliogiannis P, Palomba G, Pisano M, Casula M, Fois AG, Zinellu A, Palmieri G.   +7 more
europepmc   +1 more source

Comparison of the Effects of Sorafenib and Stem Cell Secretome on HepG2 Cancer Cells with Respect to the Ras/Raf/MEK/ERK Pathway. [PDF]

J Clin Med
Gładyś A, Skubis-Sikora A, Sikora B, Pogoda-Mieszczak K, Wieczorek P, Bogunia E, Czekaj P.   +6 more
europepmc   +1 more source