Results 261 to 270 of about 231,542 (282)
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Pyrrolopyridazine MEK inhibitors
Bioorganic & Medicinal Chemistry Letters, 2006The synthesis and SAR of a series of pyrrolopyridazine MEK inhibitors are reported. Optimal activity was achieved by incorporation of a 4-phenoxyaniline substituent at C4 and an acylated amine at C6.
Zhong, Chen +12 more
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Current Opinion in Oncology, 2020
Purpose of review An early understanding of the role of the Ras/Raf/MEK/ERK signalling pathway in regulating cell proliferation has set the stage for the development of several potent and selective MEK inhibitors (MEKi). MEKi represent promising therapies for RAS-driven neoplasias and RASopathies associated with increased Ras ...
Christina, Bergqvist +1 more
openaire +2 more sources
Purpose of review An early understanding of the role of the Ras/Raf/MEK/ERK signalling pathway in regulating cell proliferation has set the stage for the development of several potent and selective MEK inhibitors (MEKi). MEKi represent promising therapies for RAS-driven neoplasias and RASopathies associated with increased Ras ...
Christina, Bergqvist +1 more
openaire +2 more sources
Science's STKE, 2001
The Ras-Raf-MEK [(mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) kinase]-MAPK signaling pathway controls the activation of many cellular functions. Recent reports of Raf-1-deficient mice have indicated that MEK may not be an important downstream substrate for Raf-1 and that, in fact, Raf-1 is important for ...
M S, Murakami, D K, Morrison
openaire +2 more sources
The Ras-Raf-MEK [(mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) kinase]-MAPK signaling pathway controls the activation of many cellular functions. Recent reports of Raf-1-deficient mice have indicated that MEK may not be an important downstream substrate for Raf-1 and that, in fact, Raf-1 is important for ...
M S, Murakami, D K, Morrison
openaire +2 more sources
MEK Retinopathy. Clinical case reports
Archivos de la Sociedad Española de Oftalmología (English Edition), 2018Three clinical cases are presented of MEK retinopathy associated with the combination of cobimetinib and vemurafenib characterised by alteration of the retinal pigment epithelium and neurosensory detachment. Two of the cases conserved the vision of the unit, and the third developed a large bilateral neurosensory detachment with final visual acuity of 0.
P, Rocha Cabrera +4 more
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MEK Inhibition in BRAF-Mutated Melanoma
New England Journal of Medicine, 2012Korrespondenz zu 10.1056 ...
Flaherty, Keith T. +2 more
openaire +4 more sources
Bioorganic & Medicinal Chemistry Letters, 2009
An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.
Haile, Tecle +13 more
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An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.
Haile, Tecle +13 more
openaire +2 more sources
Retinopatía MEK. Casos clínicos
Archivos de la Sociedad Española de Oftalmología, 2018Resumen Casos clinicos Se presentan 3 casos clinicos de retinopatia MEK asociados al uso de la combinacion de cobimetinib y vemurafenib, caracterizados por la alteracion del epitelio pigmentario de la retina y desprendimiento neurosensorial. Dos de ellos conservaron la vision de la unidad, el tercero desarrollo un gran desprendimiento neurosensorial
P. Rocha Cabrera +4 more
openaire +1 more source