Results 41 to 50 of about 133,463 (299)
Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells. [PDF]
, 2016 Vascular endothelial cells can survive under hypoxic and inflammatory conditions by alterations of the cellular energy metabolism. In addition to high rates of glycolysis, glutaminolysis is another important way of providing the required energy to ...
Yong Ning +15 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Rechnergestuetztes Analysieren mit dem MTM-MEK-Verfahren
, 2022 S.22-26Für die Ablauf- und Zeitanalayse manueller Arbeitsabläufe sowie deren Gestaltung werden häufig MTM-Analysiersysteme, insbesondere MEK und UAS genutzt.
Monitor, P., Kühn, F.M.
core +1 more source
Range Space and Similarity Transformation Using Symbolic Mathematics in Python
IEEE AccessLinear systems involved in engineering and scientific calculations can be more easily analyzed using similarity transformation. However, understanding the numerous abstract linear algebra theorems associated with this transformation can be challenging ...
Chainarong Wisassakwichai +1 more
doaj +1 more source
OncoImmunology, 2018 The profound but frequently transient clinical responses to BRAFV600 inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies.
Natalia Pieper +17 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Critical Thinking and Its Implications for Contemporary Ijtihad
American Journal of Islam and Society, 2010 As an intellectual process, critical thinking plays a dynamic role in reconstructing human thought. In Islamic legal thought, this intellectual tool was pivotal in building a full-fledged jurisprudential system during the golden age of Islamic ...
Sayed Sikandar Shah, Mek Wok Mahmud
doaj +1 more source
MEK genomics in development and disease [PDF]
Briefings in Functional Genomics, 2012 The mitogen-activated protein kinase kinases (the MAPK/ERK kinases; MKKs or MEKs) and their downstream substrates, the extracellular-regulated kinases have been intensively studied for their roles in development and disease. Until recently, it had been assumed any mutation affecting their function would have lethal consequences.
Bromberg-White, Jennifer L. +2 more
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Alexandria Engineering Journal, 2023 Mitogen-activated protein kinase (MEK) inhibitors and oncolytic virotherapy are identified as promising cancer therapies that can enhance the efficacy of other cancer treatments.
M. Moksud Alam +5 more
doaj +1 more source