Results 31 to 40 of about 133,463 (299)

New features in MEK retinopathy [PDF]

BMC Ophthalmology, 2018
The use of molecularly targeted therapy is becoming widespread in oncology. These agents cause tumour-specific genetic alterations in signal transduction pathways, hence less generalised toxicity. Dabrafenib, a BRAF inhibitor and Trametinib, a MEK inhibitor are two molecularly targeted agents recently approved for treatment of advanced, unresectable ...
Pallavi Tyagi, Cynthia Santiago
openaire   +3 more sources

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

Platelets, 2019
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy, Jonathan M. Gibbins   +6 more
doaj   +1 more source

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors [PDF]

, 2019
Kinases such as MEK are attractive targets for novel therapy in cancer, including acute myeloid leukaemia (AML). Acquired and inherent resistance to kinase inhibitors, however, is becoming an increasingly important challenge for the clinical success of ...
Smith, Amanda M., Smith, Amanda M, Moore, Andrew S., Cristino, Alexandre S, Fink, J Lynn, Moore, Andrew S, Fink, Lynn J., Cristino, Alexandre S., Zhang, CRC, Grady, John P, Cristino, Alexandre, Moore, AS, Zhang, Christine R.C., Grady, John P., Grady, JP, Fink, JL, Smith, AM   +16 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Evidence for an Oceanic Source of Methyl Ethyl Ketone to the Atmosphere

Geophysical Research Letters, 2020
Methyl ethyl ketone (MEK) is a relatively abundant but understudied oxygenated volatile organic compound that can serve as a source of both HOx and PAN when photooxidized.
J. F. Brewer, E. V. Fischer, R. Commane, S. C. Wofsy, B.C. Daube, E. C. Apel, A. J. Hills, R. S. Hornbrook, B. Barletta, S. Meinardi, D. R. Blake, E. A. Ray, A. R. Ravishankara   +12 more
doaj   +1 more source

Up-regulation of hepatitis C virus replication and production by inhibition of MEK/ERK signaling. [PDF]

PLoS ONE, 2009
BACKGROUND: Viruses interact with and exploit the host cellular machinery for their multiplication and propagation. The MEK/ERK signaling pathway positively regulates replication of many RNA viruses.
Jean Ndjomou, In-woo Park, Ying Liu, Lindsey D Mayo, Johnny J He   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comparative Analysis of Energy Efficiency in High-Voltage Ozone Generators: Resonant Versus Non-Resonant Systems

Energies
The effective generation of ozone by high-voltage systems is essential for several industrial and environmental purposes. This paper performs a thorough comparative examination of energy efficiency in ozone generators, emphasizing resonant and non ...
Tongpian Prombud, Ekkapol Anusurain, Chainarong Wisassakwichai, Choosak Kamonkhantithorn   +3 more
doaj   +1 more source

Clean production of methyl ethyl ketone (MEK)

Revista Facultad de Ingeniería Universidad de Antioquia, 2004
Methyl ethyl ketone oxime (MEKO) was obtained by reaction of methyl ethyl ketone (MEK) with ammonia and hydrogen peroxide using titanium silicalite-1 (TS-1) as catalyst. The effect of reaction temperature, type of solvent, molar ratios of NH3/MEK, H2O2/
César Augusto Caro Muñoz, Elkin Antonio Alfonso Sossa, Consuelo Montes de Correa   +2 more
doaj   +1 more source

Identification of direct transcriptional targets of V600EBRAF/MEK signalling in melanoma

, 2009
Oncogenic mutations in BRAF are common in melanoma and drive constitutive activation of the MEK/ERK pathway. To elucidate the transcriptional events downstream of V600EBRAF/MEK signalling we performed gene expression profiling of A375 melanoma cells ...
East, Philip, Reis-Filho, Jorge S., Marais, Richard, Philip East, Jorge S Reis‐Filho, Leisl M Packer, Richard Marais, Packer, Leisl M.   +7 more
core   +1 more source