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MEK genomics in development and disease [PDF]
Briefings in Functional Genomics, 2012 The mitogen-activated protein kinase kinases (the MAPK/ERK kinases; MKKs or MEKs) and their downstream substrates, the extracellular-regulated kinases have been intensively studied for their roles in development and disease. Until recently, it had been assumed any mutation affecting their function would have lethal consequences.
Bromberg-White, Jennifer L. +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
EnergiesThe effective generation of ozone by high-voltage systems is essential for several industrial and environmental purposes. This paper performs a thorough comparative examination of energy efficiency in ozone generators, emphasizing resonant and non ...
Tongpian Prombud +3 more
doaj +1 more source
Clean production of methyl ethyl ketone (MEK)
Revista Facultad de Ingeniería Universidad de Antioquia, 2004 Methyl ethyl ketone oxime (MEKO) was obtained by reaction of methyl ethyl ketone (MEK) with ammonia and hydrogen peroxide using titanium silicalite-1 (TS-1) as catalyst. The effect of reaction temperature, type of solvent, molar ratios of NH3/MEK, H2O2/
César Augusto Caro Muñoz +2 more
doaj +1 more source
Alexandria Engineering Journal, 2023 Mitogen-activated protein kinase (MEK) inhibitors and oncolytic virotherapy are identified as promising cancer therapies that can enhance the efficacy of other cancer treatments.
M. Moksud Alam +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Range Space and Similarity Transformation Using Symbolic Mathematics in Python
IEEE AccessLinear systems involved in engineering and scientific calculations can be more easily analyzed using similarity transformation. However, understanding the numerous abstract linear algebra theorems associated with this transformation can be challenging ...
Chainarong Wisassakwichai +1 more
doaj +1 more source
OncoImmunology, 2018 The profound but frequently transient clinical responses to BRAFV600 inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies.
Natalia Pieper +17 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Critical Thinking and Its Implications for Contemporary Ijtihad
American Journal of Islam and Society, 2010 As an intellectual process, critical thinking plays a dynamic role in reconstructing human thought. In Islamic legal thought, this intellectual tool was pivotal in building a full-fledged jurisprudential system during the golden age of Islamic ...
Sayed Sikandar Shah, Mek Wok Mahmud
doaj +1 more source