Results 11 to 20 of about 133,463 (299)
Expert Opinion on Emerging Drugs, 2010 The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signaling molecules. Integral components of this pathway such as Ras and B-Raf are also activated by mutation. The Ras/Raf/MEK/ERK pathway has profound effects on proliferative, apoptotic and differentiation pathways.
J.A. McCubrey +15 more
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Emilien Loeuillard, PhD +2 more
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MEK-independent regulation of FRA-1 and implications for EMT-TF reprogramming
, 2023 The main drivers of cutaneous malignant melanoma (MM) are mutations in BRAF and NRAS oncogenes, which stimulate MEK-ERK signalling. FRA-1, an effector of the NRAS and BRAF pathways, is a modulator of cellular plasticity and epithelial mesenchymal ...
Mohammad N. Jaunbocus (17108520)
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Patient-Centered Design Method for Self-Powered and Cost-Optimized Health Monitors
IEEE Access, 2023 The emergence of Wireless Body Area Networks (WBANs) with health monitoring capabilities has revolutionized health care. Implementing fully independent WBAN nodes is important to the long-term viability of this initiative.
Molly Sharone, Ali Muhtaroglu
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OBP-702 suppresses the EGFR-MEK-ERK and AKT-mTOR signaling pathways in BRAF-mutant CRC cells.
, 2023 A BRAF-mutant HT29 cells were treated with OBP-301 or OBP-702 at the indicated MOI for 72 h. Cell lysates were prepared and subjected to Western blot analysis of EGFR, MEK, ERK, AKT, and mTOR expression. B BRAF-mutant HT29 cells were treated with OBP-301,
Shuta Tamura (17403537) +9 more
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Molecular Cell, 2001 Myogenesis is inhibited by receptor activation of Ras through the MEK and ERK kinases, but the underlying mechanism is unclear. In this issue of Molecular Cell, Perry et al. show that activated MEK1 forms an inhibitory complex with myogenic transcription factors in the nucleus.
Penn, Bennett H. +3 more
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Optimizing photoswitchable MEK [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Controlling access to the active sites of kinases using photo-dimerizable domains revolutionizes the types of possible optogenetic perturbations of cell signaling. This technology, however, is useful only when there is strong kinase activity to harness. We report a strategy to systematically enhance and tune functionality
Aleena L. Patel +6 more
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The board and IT governance: The what, who and how
South African Journal of Business Management, 2010 This paper discusses the importance of corporate governance and the need to implement it effectively in any organization. Furthermore, information technology is discussed along with its impact on enabling an organization to achieve its business goals and
S. Posthumus, R. Von Solms, M. King
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Cell Cycle, 2002 The MEK family of protein kinases plays key roles in regulating cellular responses to mitogens as well as environmental stress. Inappropriate activation of these kinases contributes to tumorigenesis. In contrast, anthrax lethal factor, the principal virulence factor of anthrax toxin, has been demonstrated to selectively inactivate MEKs. In this article
J F, Bodart +3 more
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