Results 71 to 80 of about 133,463 (299)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

MEK inhibitors for the treatment of NRAS mutant melanoma

, 2018
Saro Sarkisian,1 Diwakar Davar2 1Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA; 2Division of Hematology-Oncology, Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA Abstract: Melanoma is ...
Davar D, Sarkisian, Saro, Sarkisian S, Davar, Diwakar   +3 more
core  

SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models

, 2018
Adaptive resistance to MEK inhibitors (MEK-Is) typically occurs via induction of genes for different receptor tyrosine kinases (RTKs) and/or their ligands, even in tumors of the same histotype, making combination strategies challenging.
Kiyomi Araki, Carmine Fedele, Benjamin G Neel, Hao Ran, Diane M Simeone, Jayu Jen, Kwan Ho Tang, Wei Wei, George Miller, Brian Diskin   +9 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720

, 2011
Purpose: To examine mechanisms that determine long-term responses of B-RAFV600E melanoma cells to B-RAF inhibitors. Experimental Design: B-RAFV600E melanoma cells were exposed to the B-RAF inhibitor PLX4720 for prolonged periods to select for cells ...
Chen Chen Jiang (21131984), Fritz Lai (776548), Peter Hersey (441741), Xu Dong Zhang (21134519), Fan Yang (1413), Rick F. Thorne (11680261), Hao Liu (12832)   +6 more
core  

Secretogranin III promotes angiogenesis through MEK/ERK signaling pathway

, 2018
Secretogranin III (Scg3) was recently discovered as the first highly diabetic retinopathy-associated angiogenic factor, and its neutralizing antibody alleviated the disease with high efficacy in diabetic mice.
Fen Tang, Dan Liang, Li, Wei, Wei Li, Chen, Ping, Liang, Dan, Mario Thiego F. Pacheco, Pacheco, Mario Thiego F, Tang, Fen, Ping Chen   +9 more
core   +1 more source

Boosting Ferroelectricity: 2D and Polymer Ferroelectric Hybrids Enabling Ambipolar Nonvolatile MoS2 Memory Transistor

Advanced Science, EarlyView.
Two‐dimensional CuInP2S6 nanosheets are incorporated into a P(VDF‐TrFE) matrix to induce polarization‐cooperative ferroelectric coupling. The resulting P(VDF‐TrFE)/CuInP2S6 hybrid film exhibits reinforced ferroelectric ordering and reduced coercive electric fields compared with pristine P(VDF‐TrFE).
Yeonsu Jeong, Honglei Wang, Pietro Tordi, Ying Chieh Hu, Adrián Tamayo, Bing Wu, Hyun Soo Ahn, Zdenek Sofer, Jong Hoon Jung, Massimo Bonini, Paolo Samorì   +10 more
wiley   +1 more source

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies [PDF]

, 2012
: In hematological malignancies, constitutive activation of the RAF/MEK/ERK pathway is frequently observed, conveys a poor prognosis, and constitutes a promising target for therapeutic intervention.
Mascolo, Maria Grazia, Milella, Michele, Abrams, Stephen L, Konopleva, Marina, Tavolaro, Simona, Ciuffreda, Ludovica, Cognetti, Francesco, McCubrey, James A, Bergamo, Paola, Ricciardi, Maria Rosaria, Scerpa, Maria Cristina, Marchetti, Antonio, Andreeff, Michael, Foà, Robin, Steelman, Linda S, Tsao, Twee, Petrucci, Maria Teresa, Del Bufalo, Donatella, Tafuri, Agostino, Chiaretti, Sabina, Chiaretti S, Andreeff M, Mascolo MG, Scerpa MC, Bergamo P, Tavolaro S, Steelman LS, Tsao T, Foà R, Ricciardi MR, Cognetti F, Petrucci MT, Tafuri A, Ciuffreda L, Konopleva M, Milella M., Abrams SL, Del Bufalo D, McCubrey JA   +38 more
core   +2 more sources

Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in PancreatitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer, where its potential as a therapeutic target is limited by acquired drug resistance.
Christopher J. Halbrook, Hui-Ju Wen, Jeanine M. Ruggeri, Kenneth K. Takeuchi, Yaqing Zhang, Marina Pasca di Magliano, Howard C. Crawford   +6 more
doaj   +1 more source