Results 71 to 80 of about 102,002 (260)

Triple Column Pressure-Swing Distillation for Ternary Mixture of Methyl Ethyl Ketone /Isopropanol /Ethanol

Chemical Engineering Transactions, 2017
Methyl ethyl ketone (MEK), isopropanol (IPA), and ethanol (EtOH) are important chemical materials and widely used as intermediates solvent in many chemical processes.
M. Li, Y. Ma, X. Zhang, T. Zhao, Z. Zhu, Y. Wang   +5 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Acquisitions Facilitation via Blockchain Technology

Blockchain in Healthcare Today, 2018
Session Description: ACCELERATE is a transformative program in support of HHS ReImagine Acquisition.  It is designed to empower the workforce in a decentralized manner and create a flexible capability for HHS to change and implement policy.
Oki Mek, Aleksandar Zelenovic
doaj  

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

Molecular Pain, 2006
Background Numerous studies have implicated spinal extracellular signal-regulated kinases (ERKs) as mediators of nociceptive plasticity. These studies have utilized pharmacological inhibition of MEK to demonstrate a role for ERK signaling in pain, but ...
Kaplan David, Adwanikar Hita, Hu Hui-Juan, Karim Farzana, Gereau Robert W   +4 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Ultrathin, Fully Solution‐Processed P(VDF‐TrFE) Piezoelectric Sensor Matrix for Electronic Skin

Advanced Electronic Materials, EarlyView.
An ultrathin, fully solution‐processed 4×$\times$4 piezoelectric sensor array is developed for skinconformal electronicskin applications. The device integrates inkjetprinted polymer electrodes with a 226 nm P(VDFTrFE) active layer on a 4.53 μm$\umu{\rm m}$ Parylene C substrate, enabling extreme flexibility and robust tactile sensing. The array exhibits
Ninja Kajas, Karem Lozano Montero, Leena Ukkonen, Veikko Surakka, Matti Mäntysalo   +4 more
wiley   +1 more source

DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells

Cell Reports
Summary: Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors are widely applied to maintain pluripotency, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic stem cells (ESCs).
Jiayu Yu, Nannan Zhao, Yuying Wang, Nan Ding, Zhenchang Guo, Zichan He, Qingye Zhang, Jingai Zhang, Xiaoqiong Yang, Ming Zhang, Xiaoling Du, Kai Zhang, Lingyi Chen   +12 more
doaj   +1 more source

Hubungan Kuantitatif Struktur-Aktivitas (HKSA) dan Penambatan Molekul Senyawa Turunan Benzamida sebagai Inhibitor Alosterik Mitogen Enhanced Kinase (MEK)

Jurnal Kimia Valensi, 2018
Jalur sinyal protein kinase Ras-Raf-MEK-ERK adalah salah satu target penting dalam penemuan obat antikanker. Senyawa turunan benzamida diketahui berpotensi sebagai inhibitor alosterik Mitogen Enhanced Kinase (MEK).
Muhammad Arba, Ruslin Ruslin, Nursan Nursan, Maulidiyah Maulidiyah, Daryono Hadi Tjahjono   +4 more
doaj   +1 more source