Results 81 to 90 of about 133,463 (299)

RUNX2/CBFB modulates the response to MEK inhibitors through activation of receptor tyrosine kinases in KRAS-mutant colorectal cancer

Translational Oncology, 2020
Intrinsic and acquired resistances are major hurdles preventing the effective use of MEK inhibitors for treatment of colorectal cancer (CRC). Some 35–45% of colorectal cancers are KRAS-mutant and their treatment remains challenging as these cancers are ...
Tonći Šuštić, Evert Bosdriesz, Sake van Wageningen, Lodewyk F.A. Wessels, René Bernards   +4 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Balanced inter-relay charging buffer-aided IOT networks

EURASIP Journal on Wireless Communications and Networking
Although energy harvesting enables self-sustaining operation in relay-assisted networks, its effectiveness is often hindered by the unpredictable nature of energy availability, which can result in transmission outages.
Mohammad Alkhawatrah, Muhammad AlAyyad, Olga Korostynska   +2 more
doaj   +1 more source

Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

BMC Cancer, 2018
Background The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN.
Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills, Bryan T. Hennessy   +5 more
doaj   +1 more source

Isoalantolactone inhibits radiation-induced Mek and Erk1/2 protein phosphorylation in UMSCC-10A cells.

, 2016
(A) Whole-cell protein extracts were prepared from UMSCC-10A cells that were treated with radiation and isoalantolactone alone or in combination. Isoalantolactone at a dose of 5 μM was added to the cultured cells 16 hours prior to radiation 4 Gy exposure.
Hongguo Gao (840986), Jiehua Hu (464935), Hongyan Wang (41596), Yonggang Fan (840985), LiHua Li (123061), Zhiyong Weng (107276), Hua Liu (63708)   +6 more
core   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

A Temperature-Sensitive MEK Mutation Demonstrates the Conservation of the Signaling Pathways Activated by Receptor Tyrosine Kinases

, 2021
MEK, a dual specificity threonine/tyrosine kinase, has been postulated to be a convergent point for signaling from receptor protein tyrosine kinases (RTKs) and G-protein-coupled receptors.
Hsu, Jui-Chou, Perrimon, Norbert
core   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Spatio-temporal activation of MEK.

, 2013
(A) Following location-specific activation of EGFR for the indicated times, the spatio-temporal activation of MEK was determined by subcellular fractionation followed by immunoblotting with anti-pMEK antibody as described in Experimental procedures.
Jennifer Jiang (307858), Peng Wu (210686), Zhixiang Wang (307861), Xinmei Chen (307859), Ping Wee (307857)   +4 more
core   +1 more source