Results 101 to 110 of about 133,463 (299)

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells

Cell Reports
Summary: Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors are widely applied to maintain pluripotency, while prolonged MEK inhibition compromises the developmental potential of mouse embryonic stem cells (ESCs).
Jiayu Yu, Nannan Zhao, Yuying Wang, Nan Ding, Zhenchang Guo, Zichan He, Qingye Zhang, Jingai Zhang, Xiaoqiong Yang, Ming Zhang, Xiaoling Du, Kai Zhang, Lingyi Chen   +12 more
doaj   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Destructive Effect of Monopolar Electrocautery Knife Usage on Femoral Artery Endothelium During Spine Surgery: Experimental Study

Eurasian Journal of Medicine, 2019
Objective. Circulatory disorders are observed in the lower extremities of some patients after spinal surgery when a monopolar electrocautery knife (MEK) is used.
Ednan Bayram, Muhammet Çalik, Canan Atalay, Mehmet Dumlu Aydin, Cemal Gundogdu, Hasan Kocaturk   +5 more
doaj  

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Effects of RAF, MEK, and RAF/MEK inhibitors on cancer cell lines with or without RAS, BRAF, PIK3CA, or PTEN mutations.

, 2014
CH; CH5126766, PD; PD0325901, PLX; PLX4720 IC50 (nM).Effects of RAF, MEK, and RAF/MEK inhibitors on cancer cell lines with or without RAS, BRAF, PIK3CA, or PTEN mutations.
Makoto Wada (12542), Toshiyuki Sakai (309632), Norito Katoh (665914), Toshikazu Yamazaki (665913), Mano Horinaka (665912)   +4 more
core   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Prolonged Mitogen-Activated Protein Kinase Kinase (MEK) Inhibition Induces Increase in Proteolysis and Compensatory Phosphorylation of MEK and Protein Kinase B (AKT) in Plexiform Neurofibroma Cells

Cells
Plexiform neurofibromas associated with neurofibromatosis type I (pNF1s) are benign tumors caused by the complete loss of function of the NF1 gene, which encodes a negative regulator of the RAS/mitogen-activated protein kinase (MAPK) pathway. pNF1s carry
Kyungmin Ji, John F. Callaghan, Thomas J. Ridella, Raymond R. Mattingly   +3 more
doaj   +1 more source

Inhibition of Ras/MEK/ERK signaling pathway in MCF-7 and MCF-7/ADR cells by EVO.

, 2014
Whole-cell lysates were generated and immunoblotted with antibodies against Ras, phosphorylated MEK (P-MEK), MEK, phosphorylated ERK (P-ERK1/2), ERK1/2 and GAPDH. Similar results were obtained in two or three separate experiments.
Shengpeng Wang (565046), Meiwan Chen (565048), Yitao Wang (313075), Zhi Shi (303124), Lu Wang (45927), Zhangfeng Zhong (565047)   +5 more
core   +1 more source