Results 121 to 130 of about 102,002 (260)

Rosai-Dorfman disease with <i>MAP2K1</i> mutation: therapeutic response to MEK inhibition after failure of conventional therapy. [PDF]

Oxf Med Case Reports
Barbosa Carvalho do Carmo C, Potiguara de Sousa AL, de Souza Alves Glória GH, Serpa Andrade Borges I, Cervantes Sartorelli A, Nonino A.   +5 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

KRAS Signaling Inhibition Induces a Targetable Metabolic Dependency on Lipophagy-Dependent Fatty Acid Oxidation in Pancreatic Cancer. [PDF]

Cancer Res
Thakur R, Wang D, Hu T, He C, Zhao J, Suresh V, Rajacharya GH, Pradhan AK, Chumak V, Valenzuela CA, Kushwaha AD, LaBreck DA, Oh TG, Fung KM, Zhao D, Takebe N, Ulahannan SV, Shukla SK, Bryant KL, Der CJ, Mehla K, Singh PK.   +21 more
europepmc   +1 more source

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, EarlyView.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

Correction: Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis. [PDF]

Biochem J
Wang JY, Wang PY, Rao JN, Zou T, Liu L, Xiao L, Yu TX, Turner DJ, Gorospe M, Wang JY.   +9 more
europepmc   +1 more source

Deciphering the Inflammatory Network in Pediatric Recurrent Tonsillitis: The Role of TRAF6, IRAK1, and miR‐146a‐5p

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel, Çilem Özdemir, Tuba Edgünlü, Ozan Gökdoğan   +3 more
wiley   +1 more source

Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE^-/- mice via regulating estrogen receptor α. [PDF]

Chin Med
Chen L, Shi JH, Ma XJ, Chai H, Wei KK, Yang Z, Tan Y, Huang HB, Shi DZ, Qu H.   +9 more
europepmc   +1 more source

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source

Gender dynamics of tropical wildmeat systems: A systematic map of women's roles and influence

People and Nature, EarlyView.
Abstract Wildmeat is a vital natural resource globally, which must be managed sustainably to avoid livelihood insecurity, species decline and biodiversity loss. Women have a pivotal role in harvesting, processing and distributing wildmeat, yet their contributions are often overlooked.
Jasmin Willis Key, Wahyu Nurbandi, Brenda González‐Nava, Juanita Gomez, Ferdinand Castera, Guilherme Costa Alvarenga, Auriane Flottes De Pouzols, Maya Lemaire, Jennifer F. Linden, Emily K. Madsen, Lauren Coad, Amy Hinsley, E. J. Milner‐Gulland   +12 more
wiley   +1 more source

TEAD inhibitors synergize with MEK, SHP2 and mTOR inhibitors in NF1 and NF2 cell lines. [PDF]

MicroPubl Biol
Yang Y, Gurunathan S, Schechter S, Field J.   +3 more
europepmc   +1 more source