Results 131 to 140 of about 102,002 (260)

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

MEK interactions tune RAF kinase sensitivity to conformation-selective inhibition. [PDF]

Nat Chem Biol
Stoddard EG, Perera BGK, Fang L, Brush DS, Zhong Y, Potter ZE, Simon JJ, Golkowski M, Maly DJ.   +8 more
europepmc   +1 more source

Ded-Mek [PDF]

Nature, 2018
openaire   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Exploring the Role of the MAPK Signalling Pathway in Dog Immunity: From Cancer to Parasitic Diseases. [PDF]

Parasite Immunol
Ribeiro FN, Morgado FN, Porrozzi R.
europepmc   +1 more source

From Innovation to Sustainability: Integrating Fintech, Green Trade and Knowledge Systems for Circular Growth in Sub‐Saharan Africa

Sustainable Development, EarlyView.
ABSTRACT The transition toward circular and sustainable growth remains a major challenge in Sub‐Saharan Africa (SSA), where resource constraints, limited recycling capacity, and infrastructure deficits constrain environmental performance. Drawing on circular economy and innovation systems perspectives, this study examines how financial technology ...
Emmanuel Kwaku Manu, Bismark Asante, Maria L. Gorbunova, Isaiah Nketiah   +3 more
wiley   +1 more source

BRAF V600E-mutated metastatic Wilms tumor with complete response to targeted RAF/MEK inhibition: a post-treatment follow-up case report. [PDF]

Front Oncol
Slika I, Edwards CK, Cohen KJ, Friedman AD, Pratilas CA, Odeniyide P.   +5 more
europepmc   +1 more source

Impact of Technological Innovation, Environmental Policy, and Policy Inclusion on Renewable Energy Adoption in Sub‐Sahara Africa

Thunderbird International Business Review, EarlyView.
ABSTRACT This study investigates the factors influencing renewable energy consumption and renewable electricity in Sub‐Sahara Africa (SSA) using the Lewbel 2SLS approach, panel quantile regression and Driscoll and Kraay estimator. It focuses on a panel dataset covering 41 countries from 1998 to 2020.
Emmanuel K. Manu, Simplice A. Asongu
wiley   +1 more source

Successful rechallenge of BRAF/MEK inhibitor with ruxolitinib in BRAF/MEK inhibitor-induced hemophagocytic lymphohistiocytosis like hyperinflammatory syndrome in <i>BRAF</i> V600E-mutated lung adenocarcinoma: a case report. [PDF]

Front Oncol
Chandra S, Hansraj S, Adhikari A, Ponvilawan B, Tolentino A, Bansal D.   +5 more
europepmc   +1 more source