Results 41 to 50 of about 13,359 (150)

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

Brain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar, Maysa Al‐Hussaini, Vani Santosh, Vaishali Suri, Sung‐Hye Park, Yue‐Shan Piao, Tarik Tihan, Ho‐Keung Ng, Michael Buckland, Rakesh Jalali, Yonehiro Kanemura, Pieter Wesseling, Takashi Komori   +12 more
wiley   +1 more source

Oxidative Stress Modulates DNA Methylation during Melanocyte Anchorage Blockade Associated with Malignant Transformation

Neoplasia: An International Journal for Oncology Research, 2007
Both oxidative/nitrosative stress and alterations in DNA methylation are observed during carcinogenesis of different tumor types, but no clear correlation between these events has been demonstrated until now.
Ana C.E. Campos, Fernanda Molognoni, Fabiana H.M. Melo, Luciano C. Galdieri, Célia R.W. Carneiro, Vânia D'Almeida, Mariangela Correa, Miriam G. Jasiulionis   +7 more
doaj   +1 more source

Circumscribed Meningeal Melanocytic Neoplasms: CNS WHO Grade, Molecular Profile, and Clinical Outcomes

Brain Pathology, EarlyView.
In this study including 31 circumscribed meningeal melanocytic neoplasms (melanocytoma, intermediate‐grade melanocytic tumor [IMT], and melanoma), overall survival (OS) differed significantly among the groups, with melanoma showing significantly worse OS than melanocytoma and IMT showing intermediate OS between melanocytoma and melanoma.
Yi Zhu, Nishika Karbhari, Timothy J. Kaufmann, Aditya Raghunathan, Cristiane M. Ida, Cinthya J. Zepeda‐Mendoza, Ian J. Dryden, Shahriar Salamat, Chathu Atherton, Sarah M. Jenkins, Svetomir N. Markovic, Ugur T. Sener, Caterina Giannini   +12 more
wiley   +1 more source

Identification of a public CDR3 motif and a biased utilization of T-cell receptor V beta and J beta chains in HLA-A2/Melan-A-specific T-cell clonotypes of melanoma patients

Journal of Translational Medicine, 2009
Background Assessment of T-cell diversity, besides giving insights about the molecular basis of tumor antigen recognition, has clinical implications since it provides criteria for evaluating antigen-specific T cells clinically relevant for spontaneous ...
Natali Pier, Palermo Belinda, Caimi Luigi, Sottini Alessandra, Serana Federico, Nisticò Paola, Imberti Luisa   +6 more
doaj   +1 more source

Diagnostic Utility of PRAME Immunohistochemistry for Distinguishing Acral Melanoma From Acral Melanocytic Nevi

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Introduction Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry helps distinguish non‐acral melanocytic lesions, but few studies have addressed its value in acral lesions. We aimed to identify an optimal PRAME cut‐off score to differentiate acral melanoma (AM) from acral melanocytic nevi (AMN).
Kritsada Phatcharamaneepakorn, Panitta Sitthinamsuwan, Penvadee Pattanaprichakul, Manasmon Chairatchaneeboon, Nutcha Yodrabum   +4 more
wiley   +1 more source

Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW Melanoma Cocktail' – A mixture of monoclonal antibodies to MART-1, melan-A, and tyrosinase

BMC Cancer, 2003
Background MART-1, Melan-A, and Tyrosinase have shown encouraging results for evaluation of melanoma micrometastases in sentinel lymph nodes, as compared to conventionally used S-100 protein and HMB-45.
Kampalath Bal, Chang Chung-Che, Acker Scott M, Rao R Nagarjun, Qi Dan, Shidham Vinod B, Dawson Glen, Machhi Jinobya K, Komorowski Richard A   +8 more
doaj   +1 more source

Enhanced Melan‐A Red Chromogen Labeling in Melanoma Compared to Nevus Cells: A Diagnostic Aid in Dual Multiplex Immunohistochemistry With Ki67

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Distinguishing melanoma cells from nevus cells remains a diagnostic challenge, particularly in cases where melanoma exhibits nevoid morphology or nevus cells display atypical or epithelioid features. Accurate identification is essential for proper measurement of Breslow depth in melanomas arising in association with nevi and for ...
Peter N. Kundert, Elsayed H. Ibrahim, Victor G. Prieto, Phyu P. Aung   +3 more
wiley   +1 more source

Fat‐poor leiomyomatous angiomyolipoma arising from renal parenchyma negative for HMB‐45: A case report

Clinical Case Reports, 2022
Fat‐poor leiomyomatous angiomyolipoma, which is similar to smooth muscle tumors, is positive for smooth muscle markers and melanocytic marker human melanin black 45 (HMB‐45).
Yasuyuki Kobayashi, Shigeki Shimizu, Hiroki Arai, Kyotaro Yoshida, Masahito Honda   +4 more
doaj   +1 more source

Primary Pulmonary Perivascular Epithelioid Cell Tumour (PEComa): A Case Report

Respirology Case Reports
Perivascular epithelioid cell tumour (PEComa) is a rare mesenchymal neoplasm; lung is an exceptional primary site. Herein, we present a surgically resected case of primary pulmonary PEComa and discuss its clinicopathologic features in comparison with ...
Yu Sugimoto, Takeshi Hanagiri, Syuhei Ashikari, Takashi Iwanami, Jongkun Park   +4 more
doaj   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source