Results 201 to 210 of about 60,342 (231)

Melanocortin - 4 Receptor Agonists for the Treatment of Obesity

Current Topics in Medicinal Chemistry, 2007
The melanocortin family of receptors (MC 1-5R) and their endogenous peptide ligands (alpha, beta, gamma- MSH and ACTH) have been implicated in the control of a wide variety of behavioral and physiological functions including the homeostatic control of food intake and body weight.
Paul J, Emmerson, Matthew J, Fisher, Liang Zeng, Yan, John P, Mayer   +3 more
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Melanocortin 4 Receptor (MC4R) Deficiency

2018
An 18-year-old female student comes for an evaluation, accompanied by her parents. She has been considering bariatric surgery to manage her long-standing history of obesity. The patient reports that since early childhood, she has had “weight issues.” Her parents remember that at 12 months of age, she was always hungry and constantly seeking food.
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The genetic epidemiology of melanocortin 4 receptor variants

European Journal of Pharmacology, 2011
While rare MC4R mutations are the commonest cause of monogenic forms of extreme, early-onset obesity, growing evidence shows that common MC4R variants contribute to obesity in the general population. Candidate gene studies have focussed on the V103I and I251L MC4R variants that both affect MC(4) receptor function in vitro.
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Mutations in melanocortin-4 receptor: From fish to men

2022
Melanocortin-4 receptor (MC4R), expressed abundantly in the hypothalamus, is a critical regulator of energy homeostasis, including both food intake and energy expenditure. Shortly after the publication in 1997 of the Mc4r knockout phenotypes in mice, including increased food intake and severe obesity, the first mutations in MC4R were reported in humans
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Pharmacologic analyses of four chicken melanocortin-4 receptor mutations

Domestic Animal Endocrinology, 2016
The melanocortin-4 receptor (MC4R) is a critical regulator of mammalian food intake and energy expenditure, with receptor activation resulting in decreased food intake and increased energy expenditure. Recently, studies on role of MC4R in regulation of food intake have been extended to other species, such as chicken. Functional study of mutant MC4Rs is
Z-Q, Wang, J-S, Huang, J-H, Zhou, L, Shi, X-F, Jiang, Y-X, Tao   +5 more
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Melanocortin-4 Receptor in Energy Homeostasis and Obesity Pathogenesis

2013
The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 nonsynonymous, nonsense, deletion, and frameshift MC4R mutations have been described. Vast numbers of these mutations were identified in (extremely) obese individuals. Total or partial loss
Hinney, Anke, Volckmar, Anna-Lena, Knoll, Nadja   +2 more
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Involvement of melanocortin-4 receptor in anxiety and depression

Peptides, 2005
The melanocortins, which are derived from proopiomelanocortin, have a variety of physiological functions mediated membrane surface receptors. To date, five subtypes have been cloned. With the cloning of melanocortin receptors, studies with genetic models, and development of selective compounds, the physiological roles of the five melanocortin receptors
Shigeyuki, Chaki, Shigeru, Okuyama
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Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor

Bioorganic & Medicinal Chemistry Letters, 2006
A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was found to be increased by replacing the alpha-methyl substituent of the initial lead 11 with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or beta-alanine was incorporated onto the benzylamine ...
Wanlong, Jiang, Fabio C, Tucci, Caroline W, Chen, Melissa, Arellano, Joe A, Tran, Nicole S, White, Dragan, Marinkovic, Joseph, Pontillo, Beth A, Fleck, Jenny, Wen, John, Saunders, Ajay, Madan, Alan C, Foster, Chen, Chen   +13 more
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Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity

Journal of Medicinal Chemistry, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi P, Nargund, Alison M, Strack, Tung M, Fong   +2 more
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Functional Role, Structure, and Evolution of the Melanocortin‐4 Receptor

Annals of the New York Academy of Sciences, 2003
Abstract: The melanocortin (MC)‐4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC‐4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4‐week chronic blockage of the MC‐4 receptor leads to robust increases in food intake and development ...
HB Schioth, MC Lagerstrom, H. Watanobe, L. Jonsson, VERGONI, Anna Valeria, A. Ringholm, JO Skarphedinsson, GV Skuladottir, J. Klovins, R. Fredriksson   +9 more
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