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Design, synthesis and characterisation of gurmarin and melanocortin analogues of gurmarin [PDF]
, 2012 Eliasen, Rasmus
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Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention.
Archives of Biochemistry and Biophysics, 2014Beginning in the last decade of the twentieth century, the fields of pigment cell research and melanoma have witnessed major breakthroughs in the understanding of the role of melanocortins in human pigmentation and the DNA damage response of human melanocytes to solar ultraviolet radiation (UV).
Z. Abdel‐Malek +5 more
semanticscholar +3 more sources
General and Comparative Endocrinology, 2019
Melanocortin-1 receptor (MC1R) has important roles in regulating pigmentation and inflammation. Melanocortin receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of mammalian melanocortin receptors.
Linhua Ji +4 more
semanticscholar +3 more sources
Melanocortin-1 receptor (MC1R) has important roles in regulating pigmentation and inflammation. Melanocortin receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of mammalian melanocortin receptors.
Linhua Ji +4 more
semanticscholar +3 more sources
Archives of Dermatology, 2001
Although human pigmentation is genetically complex, to date polymorphism at only 1 locus, the melanocortin-1 receptor (MC1-R), has been associated with physiologic variation in hair and skin color. The MC1-R, a G protein-coupled receptor with 7 transmembrane-spanning domains, plays a key role in determining the type of melanin (eumelanin vs pheomelanin)
J V, Schaffer, J L, Bolognia
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Although human pigmentation is genetically complex, to date polymorphism at only 1 locus, the melanocortin-1 receptor (MC1-R), has been associated with physiologic variation in hair and skin color. The MC1-R, a G protein-coupled receptor with 7 transmembrane-spanning domains, plays a key role in determining the type of melanin (eumelanin vs pheomelanin)
J V, Schaffer, J L, Bolognia
openaire +2 more sources
Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor
Gene, 2007The melanocortin type 1 receptor (Mc1r) belongs to a family of G-protein-coupled receptors involved in various physiological processes in vertebrates. Melanocortins, the Mcr natural agonists, are pituitary peptide hormones including adrenocorticotropin and melanocyte-stimulating hormones.
Yvonne, Selz +6 more
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Melanocortin‐1 receptor structure and functional regulation
Pigment Cell Research, 2005SummaryThe melanogenic actions of the melanocortins are mediated by the melanocortin‐1 receptor (MC1R). MC1R is a member of the G‐protein‐coupled receptors (GPCR) superfamily expressed in cutaneous and hair follicle melanocytes. Activation of MC1R by adrenocorticotrophin or α‐melanocyte stimulating hormone is positively coupled to the cAMP signaling ...
José C, García-Borrón +2 more
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Regulatory elements of the melanocortin 1 receptor
Peptides, 2005Among more than 120 genes that are now known to regulate mammalian pigmentation, one of the key genes is MC1R, which encodes the melanocortin 1 receptor, a seven transmembrane G protein-coupled receptor expressed on the surface of melanocytes. Since the monoexonic sequence of the gene was cloned and characterized more than a decade ago, tremendous ...
Francois, Rouzaud, Vincent J, Hearing
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The Melanocortin‐1 Receptor and Human Pigmentation
Annals of the New York Academy of Sciences, 1999ABSTRACT: α‐Melanocyte stimulating hormone (α‐MSH) is known to be the main physiologic regulator for integumental pigmentation of various vertebrate species. However, the role of α‐MSH and related melanocortins in the regulation of human cutaneous pigmentation is only beginning to be understood.
Z, Abdel-Malek +4 more
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2000
The melanocyte-stimulating hormone (MSH) receptor, recently renamed the melanocortin-1 receptor (MC1-R), is a 7 transmembrane domain receptor in the rhodopsin superfamily that plays an important role in the regulation of mammalian pigmentation. The study of the MC 1-R has introduced at least two novel paradigms to the G protein signaling field ...
Dongsi Lu +3 more
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The melanocyte-stimulating hormone (MSH) receptor, recently renamed the melanocortin-1 receptor (MC1-R), is a 7 transmembrane domain receptor in the rhodopsin superfamily that plays an important role in the regulation of mammalian pigmentation. The study of the MC 1-R has introduced at least two novel paradigms to the G protein signaling field ...
Dongsi Lu +3 more
openaire +1 more source