Results 211 to 220 of about 994,457 (252)

Melanocortin 1 receptor variation in the domestic dog

Mammalian Genome, 2000
The melanocortin 1 receptor (Mc1r) is encoded by the Extension locus in many different mammals, where a loss-of-function causes exclusive production of red/yellow pheomelanin, and a constitutively activating mutation causes exclusive production of black/brown eumelanin. In the domestic dog, breeds with a wild-type E allele, e.
J M, Newton, A L, Wilkie, L, He, S A, Jordan, D L, Metallinos, N G, Holmes, I J, Jackson, G S, Barsh   +7 more
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Genetic Studies of the Human Melanocortin‐1 Receptor

Annals of the New York Academy of Sciences, 1999
ABSTRACT: Genetic approaches have suggested a critical role for the melanocortin‐1 receptor in the control of pigmentation. We showed that this gene is unusually polymorphic in European populations and that, of the many variants, three in particular appear to be associated with red hair or fair skin.
J L, Rees, M, Birch-Machin, N, Flanagan, E, Healy, S, Phillips, C, Todd   +5 more
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The Human Melanocortin-1 Receptor

2000
One of the more obvious features that distinguishes one human from another are the pigmentatory characteristics (including skin type, hair and eye color) of the individual. Although it had been suspected (as a result of investigations into murine coat color) that several genes were likely to be involved in human pigmentation, and, although it had been ...
Eugene Healy, Mark Birch-Machin, Jonathan L. Rees   +2 more
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Expression of Functional Melanocortin 1 Receptors in Insect Cells

Biochemical and Biophysical Research Communications, 1996
We expressed epitope-tagged human melanocortin 1 receptor (MC1R) in insect cells using two different recombinant baculovirus constructs; one of which encoded MC1R with an N-terminal Flag epitope and a C-terminal polyHis tag, while the other encoded the MC1R with a C-terminal Myc tag. The constructs were used to infect Sf9 insect cells.
Schiöth, Helgi, Kuusinen, Arja, Muceniece, Ruta, Szardenings, Michael, Keinänen, Kari, Wikberg, Jarl   +6 more
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Expression of melanocortin 1 receptor in periaqueductal gray matter

NeuroReport, 1995
The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative.
Y, Xia, J E, Wikberg, V, Chhajlani
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Mechanism of dimerization of the human melanocortin 1 receptor

Biochemical and Biophysical Research Communications, 2008
The melanocortin 1 receptor (MC1R) is a dimeric G protein-coupled receptor expressed in melanocytes, where it regulates the amount and type of melanins produced and determines the tanning response to ultraviolet radiation. We have studied the mechanisms of MC1R dimerization.
Paola T, Zanna, Berta L, Sánchez-Laorden, Ana B, Pérez-Oliva, María C, Turpín, Cecilia, Herraiz, Celia, Jiménez-Cervantes, José C, García-Borrón   +6 more
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Evolutionary Genetics of the Melanocortin‐1 Receptor in Vertebrates

Annals of the New York Academy of Sciences, 2003
Abstract: The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified several genes which are ...
Nicholas I, Mundy, Joanne, Kelly, Emmalize, Theron, Kim, Hawkins   +3 more
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Melanocortin-1 receptor (MC1R): a review for dermatologists

Italian Journal of Dermatology and Venereology
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin.
Guida S., Puig S., Di Resta C., Sallustio F., Mangano E., Stabile G., Longo C., Pellacani G., Guida G., Rongioletti F.   +9 more
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Novel Agouti-Related-Protein-Based Melanocortin-1 Receptor Antagonist

Journal of Medicinal Chemistry, 2001
The melanocortin receptors are G-protein coupled receptors (GPCRs) that activate the cAMP signal transduction pathway and are stimulated by the melanocortin agonist alpha-melanocyte stimulating hormone (alpha-MSH). Members of these melanocortin receptors are antagonized by agouti (ASP) and agouti-related protein (AGRP), which are the only known ...
R, Thirumoorthy, J R, Holder, R M, Bauzo, N G, Richards, A S, Edison, C, Haskell-Luevano   +5 more
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A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals

Science, 2007
The melanocortin 1 receptor (MC1R) regulates pigmentation in humans and other vertebrates. Variants of MC1R with reduced function are associated with pale skin color and red hair in humans of primarily European origin. We amplified and sequenced a fragment of the MC1R gene ( mc1r ) from two Neanderthal remains. Both
C. CLALUEZA FOX, RHOMPLER, CARAMELLI, DAVID, C. STUBERT, G. CATALANO, D. HUGHES, N. ROHLAND, PILLI, ELENA, L. LONGO, S. CONDEMI, M. DE LA RASILLA, J. FORTEA, A. ROSAS, M. STONEKING, T. SCHNEBERG, J. BERTRANPETIT, M. HOFREITER   +16 more
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