Results 1 to 10 of about 46,589 (229)

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]

Nature Communications
The melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail, Suli-Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Uretmen Kagiali, Marie-José Blouin, Javier A. Tello, Annette G. Beck-Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter McCormick, Paolo Annibale, Heike Biebermann   +15 more
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Melanocortin-4 receptor and leptin as genes for the selection of superior Madrasin cattle [PDF]

Veterinary World, 2021
Background and Aim: The genetic improvement of cattle through livestock section is based on quantitative, qualitative, and molecular characteristics. This study examined polymorphisms of the melanocortin-4 receptor (MC4R) and leptin genes as a reference ...
Budi Utomo, Rimayanti Rimayanti, Indah Norma Triana, Amaq Fadholly   +3 more
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Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism [PDF]

Frontiers in Endocrinology, 2023
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of ...
Ruiqi Liu, Ruiqi Liu, Mike Friedrich, Katherina Hemmen, Kerstin Jansen, Mateus C. Adolfi, Manfred Schartl, Manfred Schartl, Katrin G. Heinze   +8 more
doaj   +2 more sources

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
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Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice [PDF]

The Journal of Clinical Investigation
Weight loss medications are emerging candidates for pharmacotherapy of sleep-disordered breathing (SDB). A melanocortin 4 receptor (MC4R) agonist, setmelanotide (Set), is used to treat obesity caused by abnormal melanocortin and leptin signaling.
Mateus R. Amorim, Noah R. Williams, O. Aung, Melanie Alexis Ruiz, Frederick Anokye-Danso, Junia L. de Deus, Jiali Xiong, Olga Dergacheva, Shannon Bevans-Fonti, Sean M. Lee, Jeffrey S. Berger, Mark N. Wu, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky   +14 more
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Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice [PDF]

Frontiers in Endocrinology, 2023
IntroductionFemale sexual dysfunction affects approximately 40% of women in the United States, yet few therapeutic options exist for these patients. The melanocortin system is a new treatment target for hypoactive sexual desire disorder (HSDD), but the ...
Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu, Jennifer W. Hill, Jennifer W. Hill   +9 more
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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Molecular Metabolism, 2017
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg   +27 more
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Expression of human melanocortin 4 receptor in Saccharomyces cerevisiae [PDF]

Open Life Sciences, 2011
Ignatovica Vita, Petrovska Ramona, Fridmanis Davids, Klovins Janis   +3 more
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CREB coactivator CRTC1 in melanocortin‐4 receptor‐expressing cells regulate dietary fat intake [PDF]

FASEB BioAdvances
Cyclic adenosine monophosphate‐response element‐binding protein‐1‐regulated transcription coactivator‐1 (CRTC1), a cytoplasmic coactivator that translocates to the nucleus in response to cAMP, is associated with obesity. We previously reported that CRTC1
Shigenobu Matsumura, Miyu Fujisawa, Mizuki Fujiwara, Houko Okayama, Miona Marutani, Eri Nousou, Tsutomu Sasaki, Naoki Harada   +7 more
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L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

Frontiers in Endocrinology, 2021
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but ...
Rune E. Kuhre, Rune E. Kuhre, Rune E. Kuhre, Ida M. Modvig, Ida M. Modvig, Sara L. Jepsen, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst, Jens J. Holst   +15 more
doaj   +3 more sources