Results 131 to 140 of about 46,881 (189)

On the Molecular Pharmacology of the Melanocortin-4 Receptor

, 2003
Melanocortin hormones, like alpha-MSH and ACTH (melanocyte stimulating hormone and adrenocorticotropic hormone), regulate several biological processes, including bodyweight homeostasis, neuropathic pain and nerve regeneration after nerve damage. Five melanocortin receptor subtypes have been cloned, which transduce the hormone signals via G-proteins to ...
openaire   +1 more source

Melanocortin-4 Receptor Antagonism Inhibits Colorectal and Anaplastic Thyroid Cancer In Vitro and In Vivo. [PDF]

J Clin Med
Bandini A, Banchi M, Orlandi P, Vaglini F, Alì G, Fontanini G, Ottani A, Giuliani D, Vandini E, Francia G, Carli M, Scarselli M, Bocci G.   +12 more
europepmc   +1 more source

Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum regulate affect and motor control. [PDF]

iScience
Sköld J, Lazzarino GP, Nett M, Wiskerke J, Engblom D.   +4 more
europepmc   +1 more source

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery. [PDF]

Elife
Howard CJ, Abell NS, Osuna BA, Jones EM, Chan LY, Chan H, Artis DR, Asfaha JB, Bloom JS, Cooper AR, Liao A, Mahdavi E, Mohammed N, Su AL, Uribe GA, Kosuri S, Dickel DE, Lubock NB.   +17 more
europepmc   +1 more source

Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats. [PDF]

J Clin Invest
Zhu X, Potterfield R, Gruber KA, Zhang E, Newton SD, Norgard MA, Levasseur PR, Bai P, Chen X, Gu Q, Grossberg AJ, Marks DL.   +11 more
europepmc   +1 more source

Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity. [PDF]

Int J Obes (Lond)
Galuppo B, Mannam P, Bonet J, Pierpont B, Trico' D, Haskell-Luevano C, Ericson MD, Freeman KT, Philbrick WM, Bale AE, Caprio S, Santoro N.   +11 more
europepmc   +1 more source

Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8. [PDF]

Int J Mol Sci
Anthofer L, Gmach P, Uretmen Kagiali ZC, Kleinau G, Rotter J, Opitz R, Scheerer P, Beck-Sickinger AG, Wolf P, Biebermann H, Bechmann I, Kühnen P, Krude H, Paisdzior S.   +13 more
europepmc   +1 more source

Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents.

Am J Physiol Regul Integr Comp Physiol, 2023
do Carmo JM, Dai X, Aitken N, Larson KM, Omoto ACM, Gulke RR, Wang Z, Li X, Mouton AJ, Hall JE, da Silva AA.   +10 more
europepmc   +1 more source

Melanocortin 4 Receptor-Dependent Mechanism of ACTH in Preventing Anxiety-Like Behaviors and Normalizing Astrocyte Proteins after Early Life Seizures. [PDF]

eNeuro
Khalife MR, Villarin C, Ruiz JM, McClelland SA, Rabbo KA, Matthew Mahoney J, Scott RC, Hernan AE.   +7 more
europepmc   +1 more source

The melanocortin-4 receptor pathway and the emergence of precision medicine in obesity management. [PDF]

Diabetes Obes Metab
Fansa S, Acosta A.
europepmc   +1 more source