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Melanocortin 4 receptor mutations become common
Cell Metabolism, 2021In a new paper, Wade et al. (2021) analyzed the frequency of MC4R loss-of-function (LoF) mutations in a population-based Avon Longitudinal Study of Parents and Children. The frequency was 1 in 337 and the authors showed that MC4R LoF variants significantly correlated with increased body weight and fat mass in children and adults (cumulating in ...
Peter, Kühnen +2 more
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Glutamatergic melanocortin‐4 receptor neurons regulate body weight
The FASEB Journal, 2023Abstract The locus coeruleus (LC), enriched in vesicular glutamate transporter 2 (VGlut2) neurons, is a potential homeostasis‐regulating hub. However, the identity of melanocortin‐4 receptor (MC4R) neurons in the paraventricular nucleus (PVN) of the hypothalamus, PVN VGlut2::MC4R
Haodong Liu +12 more
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Propionylpiperazines as human melanocortin-4 receptor ligands
Bioorganic & Medicinal Chemistry Letters, 2006A series of alpha-benzylpropionylpiperazines were synthesized and tested as antagonists of the melanocortin-4 receptor. In addition to its high potency and selectivity, R-11a had desirable pharmacokinetic properties including high brain penetration in mice.
Caroline W, Chen +13 more
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Anticatabolic properties of melanocortin-4 receptor antagonists
Current Opinion in Clinical Nutrition & Metabolic Care, 2006Health problems related to weight regulation are increasingly common in the USA and around the world. Although obesity and associated complications garner the most attention in the media, clinical problems at the opposite end of the spectrum, such as involuntary disease-associated weight loss or cachexia, are equally devastating. This review focuses on
Lisa D, Madison, Daniel L, Marks
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