Results 161 to 170 of about 46,881 (189)
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Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective
Diabetes/Metabolism Research and Reviews, 2012SummaryMelanocortin 4 receptor (MC4R) deficiency resulting from disruption of one or both MC4R alleles represents the commonest monogenic form of human obesity to date. Human MC4R deficiency was reported to affect 4 and 5.8% of severely obese French and British populations respectively.
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General and Comparative Endocrinology, 2019
The melanocortin-4 receptor (MC4R) acts as a member of G-protein coupled receptors and participate in food intake and energy expenditure. Melanocortin 2 receptor accessory protein 2 (MRAP2) plays a critical role in regulating MC4R signaling in mammals and zebrafish. However, evidence on their interaction in other teleost species remains elusive.
Meng, Wang +6 more
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The melanocortin-4 receptor (MC4R) acts as a member of G-protein coupled receptors and participate in food intake and energy expenditure. Melanocortin 2 receptor accessory protein 2 (MRAP2) plays a critical role in regulating MC4R signaling in mammals and zebrafish. However, evidence on their interaction in other teleost species remains elusive.
Meng, Wang +6 more
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The genetic epidemiology of melanocortin 4 receptor variants
European Journal of Pharmacology, 2011While rare MC4R mutations are the commonest cause of monogenic forms of extreme, early-onset obesity, growing evidence shows that common MC4R variants contribute to obesity in the general population. Candidate gene studies have focussed on the V103I and I251L MC4R variants that both affect MC(4) receptor function in vitro.
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Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity
Journal of Medicinal Chemistry, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ravi P, Nargund +2 more
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Functional Role, Structure, and Evolution of the Melanocortin‐4 Receptor
Annals of the New York Academy of Sciences, 2003Abstract: The melanocortin (MC)‐4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC‐4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4‐week chronic blockage of the MC‐4 receptor leads to robust increases in food intake and development ...
HB Schioth +9 more
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Melanocortin 4 Receptor (MC4R) Deficiency
2018An 18-year-old female student comes for an evaluation, accompanied by her parents. She has been considering bariatric surgery to manage her long-standing history of obesity. The patient reports that since early childhood, she has had “weight issues.” Her parents remember that at 12 months of age, she was always hungry and constantly seeking food.
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Melanocortin-5 Receptor: Pharmacology and Its Regulation of Energy Metabolism
International Journal of Molecular Sciences, 2022Ya-Xiong Tao, Ye Hong, Tao Ya-Xiong
exaly
Characterisation of melanocortin receptor subtypes by radioligand binding analysis
European Journal of Pharmacology, 1995Helgi Schioth +2 more
exaly
Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor
International Journal of Molecular Sciences, 2020Patrick Scheerer +2 more
exaly