Results 151 to 160 of about 59,513 (188)
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Melanocortin-4 receptor mutations in obesity.
Advances in clinical chemistry, 2009The current alarming spread of obesity in many parts of the world is caused by a sudden environmental shift characterized by replacement of a frugal diet with low cost, energy dense food, and little requests for physical activity during work and leisure time.
SANTINI, FERRUCCIO +5 more
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General and Comparative Endocrinology, 2018
Melanocortin 4 receptor (MC4R), which is a member of the G protein-coupled receptor (GPCR) family, mediates regulation of energy homeostasis upon the binding of α-melanocyte-stimulating hormone (α-MSH) in the central nervous system (CNS). Melanocortin 2 receptor accessory protein 2 (MRAP2) modulates the function of MC4R.
Makoto, Habara +7 more
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Melanocortin 4 receptor (MC4R), which is a member of the G protein-coupled receptor (GPCR) family, mediates regulation of energy homeostasis upon the binding of α-melanocyte-stimulating hormone (α-MSH) in the central nervous system (CNS). Melanocortin 2 receptor accessory protein 2 (MRAP2) modulates the function of MC4R.
Makoto, Habara +7 more
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2000
After cloning of the melanocyte MC1-R (1,2) and adrenocortical MC2-R (2),interest in the possibility of unique neural homologs of these receptors grew from observations of central effects of melanocortins, such as effects on learning and memory (reviewed in ref. 3) and temperature control (4).
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After cloning of the melanocyte MC1-R (1,2) and adrenocortical MC2-R (2),interest in the possibility of unique neural homologs of these receptors grew from observations of central effects of melanocortins, such as effects on learning and memory (reviewed in ref. 3) and temperature control (4).
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Melanocortin-4 Receptor Gene Polymorphisms in Obese Patients
Biochemical Genetics, 2009Obesity is a complex disease caused by both genetics and environmental factors. Melanocortin-4 receptor (MC4R) (MIM 155541) gene polymorphisms were reported to be the cause of monogenic obesity in humans. We studied three polymorphisms (Val50Met, Val103Ile, and Ser58Cys) and a mutation (Asn274Ser) of the MC4R gene in 203 obese patients and in 110 ...
YETKİN, İLHAN +8 more
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Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective
Diabetes/Metabolism Research and Reviews, 2012SummaryMelanocortin 4 receptor (MC4R) deficiency resulting from disruption of one or both MC4R alleles represents the commonest monogenic form of human obesity to date. Human MC4R deficiency was reported to affect 4 and 5.8% of severely obese French and British populations respectively.
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General and Comparative Endocrinology, 2019
The melanocortin-4 receptor (MC4R) acts as a member of G-protein coupled receptors and participate in food intake and energy expenditure. Melanocortin 2 receptor accessory protein 2 (MRAP2) plays a critical role in regulating MC4R signaling in mammals and zebrafish. However, evidence on their interaction in other teleost species remains elusive.
Meng, Wang +6 more
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The melanocortin-4 receptor (MC4R) acts as a member of G-protein coupled receptors and participate in food intake and energy expenditure. Melanocortin 2 receptor accessory protein 2 (MRAP2) plays a critical role in regulating MC4R signaling in mammals and zebrafish. However, evidence on their interaction in other teleost species remains elusive.
Meng, Wang +6 more
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The Journal of Pharmacology and Experimental Therapeutics, 1999
Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and humans; the mechanism of action includes an essential brain loop. Three melanocortin receptor subtypes are expressed in brain tissue: MC(3), MC(4,) and MC(5) receptors.
GUARINI, Salvatore +8 more
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Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and humans; the mechanism of action includes an essential brain loop. Three melanocortin receptor subtypes are expressed in brain tissue: MC(3), MC(4,) and MC(5) receptors.
GUARINI, Salvatore +8 more
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Melanocortin 4 Receptor (MC4R) Deficiency
2018An 18-year-old female student comes for an evaluation, accompanied by her parents. She has been considering bariatric surgery to manage her long-standing history of obesity. The patient reports that since early childhood, she has had “weight issues.” Her parents remember that at 12 months of age, she was always hungry and constantly seeking food.
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Characterisation of the Melanocortin 4 Receptor by Radioligand Binding
Pharmacology & Toxicology, 1996Abstract: The DNA encoding the human melanocortin 4 receptor was expressed in COS (CV‐1 origin, SV 40) cells and its radioligand binding properties was tested by using the [125I][Nle4, D‐Phe7]α‐melanocyte stimulating hormone (MSH). The radioligand was found to bind to a single saturable site with a Kd of 3.84±0.57 nmol/1 in the MC4 receptor expressing
H B, Schiöth +2 more
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Small Molecule Ligands of the Human Melanocortin-4 Receptor
Current Topics in Medicinal Chemistry, 2007Genetic and pharmacological studies, involving both animals and humans, suggest that the central MC4 receptor plays a key role in homeostatic control, most probably via regulation of appetite and energy expenditure. This has stimulated intense research efforts in the field of drug discovery to identify MC4 receptor agonists and antagonists for the ...
Feroze, Ujjainwalla, Iyassu K, Sebhat
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