Results 11 to 20 of about 46,589 (229)

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

Molecular Metabolism, 2020
Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael, Alexandre Caron, Charlotte E. Lee, Carlos M. Castorena, Syann Lee, Jeffrey M. Zigman, Kevin W. Williams, Joel K. Elmquist   +7 more
doaj   +3 more sources

Melanocortin Receptor 4 [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Melanocortin 4 receptor mutation in obesity. [PDF]

World J Exp Med
Obesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R ...
Sridhar GR, Gumpeny L.
europepmc   +3 more sources

Genetic obesity: an update with emerging therapeutic approaches [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2022
Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity.
Young Bae Sohn
doaj   +1 more source

Differential potentiation of odor aversion and yawning by melanocortin 4 receptor signaling in distinct regions of the ventral striatum. [PDF]

Front Neurosci
Alam MT, Ahasan MM, Shimizu S, Murata Y, Taniguchi M, Yamaguchi M.   +5 more
europepmc   +3 more sources

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +1 more source

Motivational dysregulation with melanocortin 4 receptor haploinsufficiency. [PDF]

NeuroImmune Pharm Ther, 2022
AbstractObesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a range of dietary fat (
Steiner AM, Roscoe RF, Booze RM, Mactutus CF.   +3 more
europepmc   +3 more sources

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source

Melanocortin-4 Receptors (MC4R)

AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2023
Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen MC4R ini menyandi sekitar 332 asam amino dan terkespresi pada hipotalamus. MC4R salah satu protein transmembran dengan memiliki tujuh subtipe protein.
Liza Arieska Saiful, Nuraiza Meutia
openaire   +1 more source

Melanocortin 4 receptors and obesity [PDF]

Archives of Disease in Childhood, 2003

openalex   +3 more sources