Results 31 to 40 of about 46,589 (229)

MRAP2 regulates ghrelin receptor signaling and hunger sensing

Nature Communications, 2017
Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Dollada Srisai, Terry C. Yin, Abigail A. Lee, Alix A. J. Rouault, Nicole A. Pearson, Justin L. Grobe, Julien A. Sebag   +6 more
doaj   +1 more source

Inhibitory effect of the melanocortin receptor agonist melanotan-II (MTII) on feeding depends on dietary fat content and not obesity in rats on free-choice diets

Frontiers in Behavioral Neuroscience, 2015
Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of ...
José eVan Den Heuvel, Leslie eEggels, Andrea evan Rozen, Eric eFliers, Andries eKalsbeek, Andries eKalsbeek, Roger eAdan, Susanne E la Fleur   +7 more
doaj   +1 more source

Association study of Melanocortin-4 Receptor (rs17782313) and PKHD1 (rs2784243) variations and early incidence of obesity at the age of maturity

Advances in Human Biology, 2023
Introduction: Obesity is primarily caused by the dysfunction of the energy homeostasis system. Numerous studies have reported an association between obesity and the rs17782313 variant near the melanocortin-4 receptor (MC4R) gene.
Yasaman Ansari, Mojgan Asadi, Iman Salahshouri Far, Nahid Pashaie, Nafise Noroozi, Mahsa M Amoli   +5 more
doaj   +1 more source

Melanocortin receptor accessory proteins in adrenal disease and obesity

Frontiers in Neuroscience, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson, Shwetha eRamachandrappa, Adrian eClark, Li eChan   +3 more
doaj   +1 more source

MC4R gene polymorphism and its association with meat traits of Karachai sheep grown in Russian Federation

Journal of Applied Animal Research, 2021
This paper presents the results on the study of melanocortin-4 receptor (MC4R) gene polymorphisms in sheep of the Karachai breed. AA, AG, and GG genotypes were determined to have allele frequencies of 47%, 37%, and 16%, respectively, indicating that ...
Ivan Fiodorovich Gorlov, Nadezhda Vasilievna Shirokova, Elena Yurievna Anisimova, Marina Ivanovna Slozhenkina, Yuriy Anatolievich Kolosov, Arkadiy Kanurovich Natyrov, Anatoliy Yurievich Kolosov, Natalia Ivanovna Mosolova, Maria Anatolievna Kolosova, Timur Tazretovich Tarchokov, Aleksandr Anatolievich Mosolov, Daria Aleksandrovna Mosolova, Ekaterina Vladimirovna Karpenko   +12 more
doaj   +1 more source

Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling

Journal of Sport and Health Science, 2023
Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li, Jinye Liang, Cong Zhang, Tiemin Liu, Chao Zhang   +4 more
doaj   +1 more source

Melanocortin 4 receptors switch reward to aversion [PDF]

Journal of Clinical Investigation, 2018
The ability to recognize and avoid noxious stimuli is essential for survival. The factors that determine whether a given stimulus is considered positive or negative are complex and not fully understood. In this issue of the JCI, Klawonn and colleagues demonstrate that melanocortin 4 receptor (MC4R) signaling is critical for proper responses to negative
Alexandra G, DiFeliceantonio, Paul J, Kenny   +1 more
openaire   +2 more sources

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor [PDF]

Journal of the Endocrine Society, 2018
Melanocortin 4 receptor (MC4R), a canonical melanocyte-stimulating hormone receptor, is the main responsible for monogenic obesity in humans. Previous studies in fish and avian species showed that MC4R becomes an ACTH receptor after interaction with the melanocortin receptor accessory protein 2 (MRAP2).
Lucia Soletto, Sergio Hernández-Balfagó, Ana Rocha, Patrick Scheerer, Gunnar Kleinau, José Miguel Cerdá-Reverter   +5 more
openaire   +3 more sources

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

Frontiers in Immunology, 2019
To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive neurologic deterioration, creating a high, and unmet medical need. One potential way to fight MS may be by limiting the detrimental
Alwin Kamermans, Tom Verhoeven, Bert van het Hof, Jasper J. Koning, Lauri Borghuis, Maarten Witte, Jack van Horssen, Helga E. de Vries, Merel Rijnsburger   +8 more
doaj   +1 more source

Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)

Frontiers in Endocrinology, 2020
Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao, Min Tao, Ren-Lei Ji, Lu Huang, Si-Yu Fan, Ting Liu, Shao-Jun Liu, Ya-Xiong Tao   +7 more
doaj   +1 more source