Results 21 to 30 of about 49,162 (239)
Frontiers in Endocrinology, 2022 The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang +15 more
doaj +1 more source
MRAP2 regulates ghrelin receptor signaling and hunger sensing
Nature Communications, 2017 Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Dollada Srisai +6 more
doaj +1 more source
Melanocortin receptors in leptin effects [PDF]
Nature, 1997 Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J. +7 more
openaire +3 more sources
Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2 [PDF]
Molecular Endocrinology, 2013 Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an accessory protein, known as melanocortin receptor 2 accessory protein 1 (MRAP1). The vertebrate genome exhibits a paralogue gene called MRAP2, which is duplicated in zebrafish (MRAP2a and MRAP2b), although its function remains ...
Agulleiro Gozalbo, Maria Josep +7 more
openaire +3 more sources
Biology, 2022 As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Jing Xu +8 more
doaj +1 more source
Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
doaj +1 more source
Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling
Frontiers in Endocrinology, 2016 Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller +16 more
doaj +1 more source
Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
Frontiers in Endocrinology, 2021 The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Meng Wang +8 more
doaj +1 more source
Differential effects of melanocortin peptides on neural melanocortin receptors.
Molecular Pharmacology, 1994 Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H. +3 more
openaire +4 more sources
Frontiers in Endocrinology, 2016 ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent on ...
Adrian John Clark +6 more
doaj +1 more source