Results 11 to 20 of about 47,532 (196)

The Multifaceted Melanocortin Receptors

Endocrinology, 2022
AbstractThe 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC2, these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that they have other poorly characterized functions.
Linda Laiho, Joanne Fiona Murray
openaire   +2 more sources

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan   +14 more
doaj   +1 more source

The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide

Endocrinology, Diabetes & Metabolism Case Reports, 2020
A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared.
Baris Akinci, Rasimcan Meral, Diana Rus, Rita Hench, Adam H Neidert, Frank DiPaola, Maria Westerhoff, Simeon I Taylor, Elif A Oral   +8 more
doaj   +1 more source

MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors [PDF]

Journal of Molecular Endocrinology, 2014
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e.
Robert M, Dores, Richard L, Londraville, Jeremy, Prokop, Perry, Davis, Nathan, Dewey, Natalie, Lesinski   +5 more
openaire   +2 more sources

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

Molecular Metabolism, 2020
Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael, Alexandre Caron, Charlotte E. Lee, Carlos M. Castorena, Syann Lee, Jeffrey M. Zigman, Kevin W. Williams, Joel K. Elmquist   +7 more
doaj   +1 more source

Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors

Data in Brief, 2016
This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016)
Akiyoshi Takahashi, Perry Davis, Christina Reinick, Kanta Mizusawa, Tatsuya Sakamoto, Robert M. Dores   +5 more
doaj   +1 more source

Melanocortins, Melanocortin Receptors and Multiple Sclerosis

Brain Sciences, 2017
The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis. This review discusses corticosteroid dependent and independent effects of melanocortins on the peripheral immune system ...
Robert P. Lisak, Joyce A. Benjamins
openaire   +3 more sources

The melanocortin action is biased toward protection from weight loss in mice

Nature Communications, 2023
The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity.
Hongli Li, Yuanzhong Xu, Yanyan Jiang, Zhiying Jiang, Joshua Otiz-Guzman, Jessie C. Morrill, Jing Cai, Zhengmei Mao, Yong Xu, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong   +11 more
doaj   +1 more source

Melanocortin receptor accessory proteins in adrenal disease and obesity

Frontiers in Neuroscience, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson, Shwetha eRamachandrappa, Adrian eClark, Li eChan   +3 more
doaj   +1 more source

MRAP2 regulates ghrelin receptor signaling and hunger sensing

Nature Communications, 2017
Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Dollada Srisai, Terry C. Yin, Abigail A. Lee, Alix A. J. Rouault, Nicole A. Pearson, Justin L. Grobe, Julien A. Sebag   +6 more
doaj   +1 more source