Results 11 to 20 of about 63,660 (228)

Melanocortin receptors in leptin effects [PDF]

Nature, 1997
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J., Yagaloff, Keith A., Fisher, Stewart L., Burn, Paul, Thiele, Todd E., Dijk, Gertjan van, Baskin, Denis G., Schwartz, Michael W.   +7 more
openaire   +5 more sources

The Multifaceted Melanocortin Receptors

Endocrinology, 2022
AbstractThe 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC2, these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that they have other poorly characterized functions.
Linda Laiho, Joanne Fiona Murray
openaire   +3 more sources

The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]

PLoS ONE, 2010
BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser, Thomas Brzoska, Vinzenz Oji, Matteo Auriemma, Maik Voskort, Verena Kupas, Lars Klenner, Cornelius Mensing, Axel Hauschild, Stefan Beissert, Thomas A Luger   +10 more
doaj   +1 more source

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors [PDF]

Journal of Molecular Endocrinology, 2014
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e.
Robert M, Dores, Richard L, Londraville, Jeremy, Prokop, Perry, Davis, Nathan, Dewey, Natalie, Lesinski   +5 more
openaire   +2 more sources

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan   +14 more
doaj   +1 more source

The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide

Endocrinology, Diabetes & Metabolism Case Reports, 2020
A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared.
Baris Akinci, Rasimcan Meral, Diana Rus, Rita Hench, Adam H Neidert, Frank DiPaola, Maria Westerhoff, Simeon I Taylor, Elif A Oral   +8 more
doaj   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF, Clark, AJ, Gorrigan, RJ, Ramachandrappa, S   +3 more
core   +2 more sources