Results 21 to 30 of about 63,660 (228)
Molecular Metabolism, 2020 Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael +7 more
doaj +1 more source
Melanocortins, Melanocortin Receptors and Multiple Sclerosis
Brain Sciences, 2017 The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis. This review discusses corticosteroid dependent and independent effects of melanocortins on the peripheral immune system ...
Robert P. Lisak, Joyce A. Benjamins
openaire +3 more sources
Data in Brief, 2016 This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016)
Akiyoshi Takahashi +5 more
doaj +1 more source
Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]
, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike +10 more
core +1 more source
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +2 more sources
The melanocortin action is biased toward protection from weight loss in mice
Nature Communications, 2023 The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity.
Hongli Li +11 more
doaj +1 more source
The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]
, 2015 The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M. +10 more
core +2 more sources
Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]
, 2007 More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters +34 more
core +1 more source
MRAP2 regulates ghrelin receptor signaling and hunger sensing
Nature Communications, 2017 Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Dollada Srisai +6 more
doaj +1 more source
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity [PDF]
, 2003 We initially performed a mutation screen of the coding region of the MC4R in 808 extremely obese children and adolescents and 327 underweight or normal-weight controls allowing for a case-control study.
Anke Hinney +40 more
core +1 more source