Results 21 to 30 of about 47,532 (196)
Frontiers in Endocrinology, 2022 The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang +15 more
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Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol
Angewandte Chemie, EarlyView.A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley +2 more sources
Biology, 2022 As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Jing Xu +8 more
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Melanocortin receptors and their accessory proteins [PDF]
Molecular and Cellular Endocrinology, 2011 The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function.
Cooray, Sadani N., Clark, Adrian J.L.
openaire +3 more sources
Frontiers in Endocrinology, 2016 ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent on ...
Adrian John Clark +6 more
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Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
Frontiers in Endocrinology, 2021 The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Meng Wang +8 more
doaj +1 more source
The melanocortin receptors and their accessory proteins [PDF]
Frontiers in Endocrinology, 2013 The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function. Since their identification almost 20 years ago much has been learnt about these receptors.
Ramachandrappa, S +3 more
openaire +5 more sources
Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling
Frontiers in Endocrinology, 2016 Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller +16 more
doaj +1 more source
Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2015 Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of ...
José eVan Den Heuvel +7 more
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