Results 1 to 10 of about 1,450 (114)
Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling [PDF]
Frontiers in EndocrinologyIntroductionMTNR1A and MTNR1B, crucial for regulating circadian rhythms and various physiological processes, have well- established biological significance.
Lingjing Jin, Yaqun Zhang, Xu Hongtao
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Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer [PDF]
Frontiers in Endocrinology, 2021 The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Chao Zhang, Meng Wang, Xiaowei Lei
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Determination of the Interaction and Pharmacological Modulation of MCHR1 Signaling by the C-Terminus of MRAP2 Protein [PDF]
Frontiers in Endocrinology, 2022 Melanin concentrating hormone (MCH), an orexigenic neuropeptide, is primarily secreted by the hypothalamus and acts on its receptor, the melanin-concentrating hormone receptor 1 (MCHR1), to regulate appetite and energy homeostasis.
Qingfeng Li, Tao Zan, Xiaomei Yang
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MRAP2 regulates ghrelin receptor signaling and hunger sensing [PDF]
Nature Communications, 2017 Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Justin L Grobe +2 more
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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]
Nature CommunicationsThe melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail +15 more
doaj +7 more sources
Biology, 2022 As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Chao Zhang, Shen Qu, Shan Bian
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Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways [PDF]
Human Molecular GeneticsAbstract The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor expressed at hypothalamic neurons that has an important role in appetite suppression and food intake. Mutations in MC4R are the most common cause of monogenic obesity and can affect multiple signaling pathways including Gs-cAMP, Gq, ERK1/2, β-arrestin ...
Caroline Gorvin, Aqfan Jamaluddin
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MRAP2 Inhibits β-Arrestin-2 Recruitment to the Prokineticin Receptor 2 [PDF]
Current Issues in Molecular BiologyMelanocortin receptor accessory protein 2 (MRAP2) is a membrane protein that binds multiple G protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, including prokineticin receptors.
Roberta Lattanzi +5 more
doaj +5 more sources
MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus) [PDF]
Biomolecules, 2021 The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of MC4R.
Zheng-Yong Wen +6 more
doaj +3 more sources
Arginine 125 Is an Essential Residue for the Function of MRAP2
International Journal of Molecular Sciences, 2022 MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is expressed in the paraventricular nucleus of the hypothalamus, where it interacts with various G protein-coupled receptors, such as the prokineticin receptors, and regulates energy expenditure and appetite.
Maria Rosaria Fullone +2 more
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