Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways [PDF]
Human Molecular GeneticsThe melanocortin-4 receptor (MC4R) is a G protein-coupled receptor expressed at hypothalamic neurons that has an important role in appetite suppression and food intake.
Rachael A. Wyatt +2 more
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Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure [PDF]
Molecular Metabolism, 2018 Objective: Melanocortin 2 receptor accessory protein 2 (MRAP2) has a critical role in energy homeostasis. Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the phenotype of gross obesity ...
Jung Dae Kim, Sabrina Diano, Li F Chan
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MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]
Nature CommunicationsThe melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail +15 more
doaj +5 more sources
Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia. [PDF]
PLoS BiologyThe G protein-coupled receptor (GPCR) melanocortin receptor 4 (MC4R) is an essential regulator of body weight homeostasis. MC4R is unusual among GPCRs in that its activity is regulated by 2 opposing physiological ligands, the agonist ⍺-MSH and the ...
Irene Ojeda-Naharros +5 more
doaj +4 more sources
Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
Frontiers in Neuroscience, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson +3 more
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Cellular signatures of melanocortin pathway genes across the locus coeruleus [PDF]
Acta Neuropathologica CommunicationsObesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD.
Alisha Basak +25 more
doaj +2 more sources
Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
Frontiers in Endocrinology, 2021 The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Meng Wang, Chao Zhang
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Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling [PDF]
Frontiers in EndocrinologyIntroductionMTNR1A and MTNR1B, crucial for regulating circadian rhythms and various physiological processes, have well- established biological significance.
Wenqi Song +12 more
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Arginine 125 Is an Essential Residue for the Function of MRAP2 [PDF]
International Journal of Molecular Sciences, 2022 MRAP2 is a small simple transmembrane protein arranged in a double antiparallel topology on the plasma membrane. It is expressed in the paraventricular nucleus of the hypothalamus, where it interacts with various G protein-coupled receptors, such as ...
Maria Rosaria Fullone +2 more
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Frontiers in Endocrinology, 2022 Melanin concentrating hormone (MCH), an orexigenic neuropeptide, is primarily secreted by the hypothalamus and acts on its receptor, the melanin-concentrating hormone receptor 1 (MCHR1), to regulate appetite and energy homeostasis.
Meng Wang, Shan Bian, Xiao-Mei Yang
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