Results 31 to 40 of about 1,970 (167)

Epigenetic Legacy: The Role of Sperm miRNAs in the Paternal Inheritance of Diabetes and Obesity Development [PDF]

Diabetes Metab Res Rev
ABSTRACT In recent decades, obesity and diabetes have reached pandemic levels, with obesity now recognised as a major health risk factor. Evidence shows that metabolic diseases are more pronounced in the offspring of malnourished parents, suggesting that predisposition can be inherited via epigenetic information in gametes.
Laurent K, Teperino R, Hrabě de Angelis M, Skerrett‐Byrne D, Beckers J.   +4 more
europepmc   +2 more sources

Six Years of Genetic Diagnosis of Severe Early-Onset Obesity in a French Cohort. [PDF]

Obes Sci Pract
ABSTRACT Objective Obesity is a multifactorial disease with a strong genetic component. It is imperative to enhance the identification of genetic variations in their early and severe manifestations in order to facilitate the development of personalized therapeutic strategies, informed clinical care, and the facilitation of genetic counseling.
Rama M, Blond E, Janin A, Di-Filippo M, Cuerq C, Marmontel O, Rollat-Farnier PA, Dieterlen E, Segrestin B, Nicolino M, Disse E, Perge K, Collin-Chavagnac D.   +12 more
europepmc   +2 more sources

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

Identification of MRAP protein family as broad‐spectrum GPCR modulators

Clinical and Translational Medicine, 2022
Background The melanocortin receptor accessory proteins (MRAP1 and MRAP2) are well‐known endocrine regulators for the trafficking and signalling of all five melanocortin receptors (MC1R–MC5R).
Meng Wang, Xiaozhu Wang, Bopei Jiang, Yue Zhai, Jihong Zheng, Liu Yang, Xiaolu Tai, Yunpeng Li, Shaliu Fu, Jing Xu, Xiaowei Lei, Zhe Kuang, Cong Zhang, Xuanxuan Bai, Mingyu Li, Tao Zan, Shen Qu, Qingfeng Li, Chao Zhang   +18 more
doaj   +1 more source

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis

Endocrine Connections, 2021
As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang   +12 more
doaj   +1 more source

The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

eLife, 2016
The Melanocortin Receptor Accessory Protein 2 (MRAP2) is an important regulator of energy homeostasis and its loss causes severe obesity in rodents. MRAP2 mediates its action in part through the potentiation of the MC4R, however, it is clear that MRAP2 ...
Anna L Chaly, Dollada Srisai, Ellen E Gardner, Julien A Sebag   +3 more
doaj   +1 more source

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis

Frontiers in Endocrinology, 2022
The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang   +8 more
doaj   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF, Clark, AJ, Gorrigan, RJ, Ramachandrappa, S   +3 more
core   +2 more sources

The Spectrum of Genetic Variants Associated with the Development of Monogenic Obesity in Qatar

Obesity Facts, 2022
Introduction: Monogenic obesity (MO) is a rare genetic disease characterized by severe early-onset obesity in affected individuals. Previous genetic studies revealed 8 definitive genes for monogenic non-syndromic obesity; many were discovered in ...
Nadien AbouHashem, Roan E. Zaied, Kholoud Al-Shafai, Mariam Nofal, Najeeb Syed, Mashael Al-Shafai   +5 more
doaj   +1 more source