Results 31 to 40 of about 1,450 (114)

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

Abstract The central melanocortin system links nutrition to energy expenditure, with melanocortin-4 receptor (MC4R) controlling appetite and food intake, and MC3R regulating timing of sexual maturation, rate of linear growth and lean mass accumulation. Melanocortin-2 receptor accessory protein-2 (MRAP2) is a single transmembrane protein
Jamaluddin A, Wyatt RA, Lee J, Dowsett GK, Tadross JA, Broichhagen J, Yeo GS, Levitz J, Gorvin CM.   +8 more
europepmc   +3 more sources

Linking the Warburg effect to endometrial receptivity: metabolic parallels in embryo implantation [PDF]

Frontiers in Cell and Developmental Biology
IntroductionEndometrial receptivity (ER), critical for successful embryo implantation and a major limiting factor in infertility affecting ∼1 in 6 couples globally, remains poorly understood, with few effective interventions targeting the embryo ...
Xiaoyang Zhang, Qingwen Zhu, Weiduo Nie, Weiduo Nie, Xiaoxue Yan, Zhihua Yuan, Leiyu Tian   +6 more
doaj   +2 more sources

Mrap2: An Accessory Protein Linked to Obesity [PDF]

Cell Metabolism, 2013
Melanocortin receptors are critical modulators of energy balance and glucose homeostasis. Companion studies published in Science (Asai et al., 2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans.
Liu, Tiemin, Elmquist, Joel K., Williams, Kevin W.   +2 more
  +9 more sources

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling

Frontiers in Endocrinology, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang, Song Xue, Xiaowei Lei, Wenqi Song, Lei Li, Xuan Li, Yanbin Fu, Cong Zhang, Hailin Zhang, Hailin Zhang, Yao Luo, Meng Wang, Gufa Lin, Gufa Lin, Chao Zhang, Jing Guo   +15 more
doaj   +1 more source

Identification of Regions Involved in the Physical Interaction between Melanocortin Receptor Accessory Protein 2 and Prokineticin Receptor 2

Biomolecules, 2022
Melanocortin Receptor Accessory Protein 2 (MRAP2) modulates the trafficking and signal transduction of several G-protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, such as Prokineticin receptors (PKRs).
Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Roberta Lattanzi, Rossella Miele   +4 more
doaj   +1 more source

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family [PDF]

Proceedings of the National Academy of Sciences, 2009
The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic–pituitary–adrenal axis, whereas MC3R and MC4R have an essential role in energy homeostasis. Mutations in MC4R are the single most common cause of monogenic obesity.
Chan, LF, Webb, TR, Chung, T-T, Meimaridou, E, Cooray, SN, Guasti, L, Chapple, JP, Metherell, LA, Clark, AJL, Egertová, M, Elphick, MR, Cheetham, ME   +11 more
openaire   +3 more sources

Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol [PDF]

Journal of Endocrinology, 2016
Melanocortin receptor accessory protein 2 (MRAP2) is a transmembrane accessory protein predominantly expressed in the brain. Both global and brain-specific deletion of Mrap2 in mice results in severe obesity. Loss-of-function MRAP2 mutations have also been associated with obesity in humans.
Novoselova, TV, Larder, R, Rimmington, D, Lelliott, C, Wynn, EH, Gorrigan, RJ, Tate, PH, Guasti, L, O'Rahilly, S, Clark, AJL, Logan, DW, Coll, AP, Chan, LF, Project, SMG   +13 more
openaire   +4 more sources

Identification of MRAP protein family as broad‐spectrum GPCR modulators

Clinical and Translational Medicine, 2022
Background The melanocortin receptor accessory proteins (MRAP1 and MRAP2) are well‐known endocrine regulators for the trafficking and signalling of all five melanocortin receptors (MC1R–MC5R).
Meng Wang, Xiaozhu Wang, Bopei Jiang, Yue Zhai, Jihong Zheng, Liu Yang, Xiaolu Tai, Yunpeng Li, Shaliu Fu, Jing Xu, Xiaowei Lei, Zhe Kuang, Cong Zhang, Xuanxuan Bai, Mingyu Li, Tao Zan, Shen Qu, Qingfeng Li, Chao Zhang   +18 more
doaj   +1 more source

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis

Endocrine Connections, 2021
As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu, Lei Li, Jihong Zheng, Meng Wang, Bopei Jiang, Yue Zhai, Liumei Lu, Cong Zhang, Zhe Kuang, Xiaomei Yang, Li-Na Jin, Gufa Lin, Chao Zhang   +12 more
doaj   +1 more source