Results 51 to 60 of about 1,450 (114)
Frontiers in Physiology, 2022 Melanocortin receptors (MC1R-MC5R) and their accessory proteins (MRAPs) are involved in a variety of physiological processes, including pigmentation, lipolysis, adrenal steroidogenesis, and immunology.
Xiao Zhang +8 more
doaj +1 more source
Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
doaj +1 more source
A novel pathogenic variant in MRAP2 in an obese patient with successful outcome of bariatric surgery
European Journal of Endocrinology, 2023 Abstract Mutations in genes encoding proteins located in the leptin/melanocortin pathway have been identified in the rare cases of genetic obesities. Heterozygous variants of MRAP2, encoding a G coupled-protein receptor accessory protein implicated in energy control notably via the melanocortin-4 receptor, have been recently identified ...
Gatta-Cherifi, Blandine +11 more
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Relevance of polymorphisms in MC4R and BDNF in short normal stature
BMC Pediatrics, 2018 Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation of genes in ...
Nikolas Herrfurth +15 more
doaj +1 more source
Current Oncology, 2021 Background: Uveal melanoma (UVM) is a rare cancer that shows sex difference in incidence and survival, with little previous report for the underlying mechanism.
Feng Liu-Smith +6 more
doaj +1 more source
Frontiers in Endocrinology, 2020 Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao +7 more
doaj +1 more source
Identifying subgroups of childhood obesity by using multiplatform metabotyping
Frontiers in Molecular Biosciences, 2023 Introduction: Obesity results from an interplay between genetic predisposition and environmental factors such as diet, physical activity, culture, and socioeconomic status.
David Chamoso-Sanchez +8 more
doaj +1 more source
Screening for pathogenic variants in obese cohort using whole-exome sequencing
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To screen mutations of key genes in the leptin-melanocyte stimulating hormone (LEP-MSH) pathway by whole-exome sequencing (WES) in the obese cohort.Methods·A total of 119 obese patients aged 17－65 years old with body mass index (BMI)≥34 kg/m2 ...
WANG Jinghui +8 more
doaj +1 more source
Analysis of the Role of the Mc4r System in Development, Growth, and Puberty of Medaka
Frontiers in Endocrinology, 2019 In mammals the melanocortin 4 receptor (Mc4r) signaling system has been mainly associated with the regulation of appetite and energy homeostasis. In fish of the genus Xiphophorus (platyfish and swordtails) puberty onset is genetically determined by a ...
Ruiqi Liu +5 more
doaj +1 more source
The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a [PDF]
Science Signaling, 2020 An accessory protein suppresses β-arrestin–dependent signaling and constitutive activity of the ghrelin receptor.
Alix A. J. Rouault +5 more
openaire +2 more sources