Results 61 to 70 of about 1,970 (167)

Relevance of polymorphisms in MC4R and BDNF in short normal stature

BMC Pediatrics, 2018
Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation of genes in ...
Nikolas Herrfurth, Anna-Lena Volckmar, Triinu Peters, Gunnar Kleinau, Anne Müller, Cigdem Cetindag, Laura Schonnop, Manuel Föcker, Astrid Dempfle, Stefan A. Wudy, Struan F. A. Grant, Thomas Reinehr, Diana L. Cousminer, Johannes Hebebrand, Heike Biebermann, Anke Hinney   +15 more
doaj   +1 more source

The Sex Differences in Uveal Melanoma: Potential Roles of EIF1AX, Immune Response and Redox Regulation

Current Oncology, 2021
Background: Uveal melanoma (UVM) is a rare cancer that shows sex difference in incidence and survival, with little previous report for the underlying mechanism.
Feng Liu-Smith, Chi-Yang Chiu, Daniel L. Johnson, Phillip Winston Miller, Evan S. Glazer, Zhaohui Wu, Matthew W. Wilson   +6 more
doaj   +1 more source

Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection [PDF]

, 2016
This work was supported by the Marie - Curie Initial Training Network INTERCROSSING (European Commission FP7). OEG was further supported by the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland)Background: The study of
Bazin, Eric, Gaggiotti, Oscar Eduardo, Vatsiou, Alexandra   +2 more
core   +3 more sources

The multifaceted melanocortin receptors [PDF]

, 2022
The 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC(2), these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that ...
Laiho, Linda, Murray, Joanne Fiona
core   +2 more sources

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

AbstractThe central melanocortin system links nutrition to energy expenditure, with melanocortin-4 receptor (MC4R) controlling appetite and food intake, and MC3R regulating timing of sexual maturation, rate of linear growth and lean mass accumulation. Melanocortin-2 receptor accessory protein-2 (MRAP2) is a single transmembrane protein that interacts ...
Jamaluddin A, Wyatt RA, Lee J, Dowsett GK, Tadross JA, Broichhagen J, Yeo GS, Levitz J, Gorvin CM.   +8 more
europepmc   +3 more sources

Targeting G protein-coupled receptors to regulate energy homeostasis [PDF]

, 2023
G protein-coupled receptors (GPCRs) have a critical role in energy homeostasis, contributing to food intake, energy expenditure and glycaemic control. Dysregulation of energy expenditure can lead to metabolic syndrome (abdominal obesity, elevated plasma ...
Gorvin, Caroline M, Jamaluddin, Aqfan
core   +1 more source

Identifying subgroups of childhood obesity by using multiplatform metabotyping

Frontiers in Molecular Biosciences, 2023
Introduction: Obesity results from an interplay between genetic predisposition and environmental factors such as diet, physical activity, culture, and socioeconomic status.
David Chamoso-Sanchez, Francisco Rabadán Pérez, Jesús Argente, Jesús Argente, Jesús Argente, Coral Barbas, Gabriel A. Martos-Moreno, Gabriel A. Martos-Moreno, Francisco J. Rupérez   +8 more
doaj   +1 more source

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk [PDF]

, 2016
Rare and low frequency variants are not well covered in most germline genotyping arrays and are understudied in relation to epithelial ovarian cancer (EOC) risk. To address this gap, we used genotyping arrays targeting rarer protein-coding variation in 8,
Ann Chen, Y, Anne Doherty, J, Anne Rossing, M, Anton-Culver, H, AOCS Study Group, ., Australian Cancer Study (Ovarian Cancer), ., Bandera, EV, Berchuck, A, Bisogna, M, Brinton, L, Brooks-Wilson, A, Carney, ME, Chen, Z, Chenevix-Trench, G, Cook, LS, Cramer, DW, Cunningham, JM, Cybulski, C, D'Aloisio, AA, Dennis, J, Dp Pharoah, P, Earp, M, Edwards, RP, Fridley, BL, Gayther, SA, Gentry-Maharaj, A, Goode, EL, Goodman, MT, Gronwald, J, Hogdall, E, Iversen, ES, Jakubowska, A, Jensen, A, Karlan, BY, Kelemen, LE, Kjaer, SK, Kraft, P, Le, ND, Levine, DA, Lin, HY, Lissowska, J, Lubinski, J, Matsuo, K, Mendoza-Fandino, G, Menon, U, Modugno, R, Monteiro, A, Moysich, KB, Nakanishi, T, Ness, RB, Olson, S, Orlow, I, Ovarian Cancer Association Consortium, ., Pearce, CL, Pejovic, T, Permuth, JB, Phelan, CM, Pirie, A, Poole, EM, Ramus, SJ, Reid, BM, Sandler, DP, Schildkraut, JM, Sellers, TA, Shu, XO, Song, H, Taylor, JA, Teo, SH, Terry, KL, Thompson, PJ, Tworoger, SS, Webb, PM, Wentzensen, N, Wilkens, LR, Winham, S, Woo, YL, Wu, AH, Yang, H, Zheng, W, Ziogas, A   +79 more
core   +1 more source

Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)

Frontiers in Endocrinology, 2020
Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao, Min Tao, Ren-Lei Ji, Lu Huang, Si-Yu Fan, Ting Liu, Shao-Jun Liu, Ya-Xiong Tao   +7 more
doaj   +1 more source

Screening for pathogenic variants in obese cohort using whole-exome sequencing

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To screen mutations of key genes in the leptin-melanocyte stimulating hormone (LEP-MSH) pathway by whole-exome sequencing (WES) in the obese cohort.Methods·A total of 119 obese patients aged 17－65 years old with body mass index (BMI)≥34 kg/m2 ...
WANG Jinghui, ZHANG Hong, ZHANG Rong, PENG Danfeng, YU Hairong, CHEN Xianghui, XUAN Ye, HU Cheng, GU Yunjuan   +8 more
doaj   +1 more source