Results 61 to 70 of about 1,450 (114)

Large-scale association study on daily weight gain in pigs reveals overlap of genetic factors for growth in humans

BMC Genomics, 2022
Background Imputation from genotyping array to whole-genome sequence variants using resequencing of representative reference populations enhances our ability to map genetic factors affecting complex phenotypes in livestock species.
Zexi Cai, Ole Fredslund Christensen, Mogens Sandø Lund, Tage Ostersen, Goutam Sahana   +4 more
doaj   +1 more source

Analyzing the signaling properties of gar (Lepisosteus oculatus) melanocortin receptors: Evaluating interactions with MRAP1 and MRAP2 [PDF]

General and Comparative Endocrinology, 2019
RT-PCR analysis of gar pituitary and brain indicated that different combinations of gar melanocortin receptor mRNAs are present in the same tissues with mRNAs for gar mrap1 and gar mrap2. Against this background, an objective of this study was to determine whether the ligand sensitivity for either ACTH or α-MSH was affected when gar (g) melanocortin ...
Emily A, Wolverton, Marty Kwok-Shing, Wong, Perry E, Davis, Brianne, Hoglin, Ingo, Braasch, Robert M, Dores   +5 more
openaire   +2 more sources

OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R

Journal of the Endocrine Society, 2020
Abstract Genetic studies in humans and mice have demonstrated that the Melanocortin 4 Receptor (MC4R) is essential for adequate regulation of food intake and body weight. MC4R is expressed in a small population of hypothalamic neurons and very little is known about its molecular and cellular dynamics in vivo.
Bernard, Adelaide A, Naharros, Irene Ojeda, Guglielmetti, Florence Bourgain, Yue, Xinyu, Vaisse, Christian   +4 more
openaire   +1 more source

RNA Sequencing and Metabolomic Analyses Reveal Differences in Muscle Characteristics and Metabolic Profiles Between Purebred and Crossbred Huainan Pigs

Animals
The HN pig, indigenous to Henan Province, is distinguished by its reduced lean meat yield and slower growth rates relative to commercial foreign breeds.
Jing Wang, Yufu Li, Mengyang Zhang, Junfeng Chen, Qingxia Lu, Hanbing Zhang, Xiangzhou Yan, Chuanying Pan, Xuelian Zhang, Baosong Xing   +9 more
doaj   +1 more source

Genome-wide detection of positive and balancing signatures of selection shared by four domesticated rainbow trout populations (Oncorhynchus mykiss)

Genetics Selection Evolution
Background Evolutionary processes leave footprints along the genome over time. Highly homozygous regions may correspond to positive selection of favorable alleles, while maintenance of heterozygous regions may be due to balancing selection phenomena.
Katy Paul, Gwendal Restoux, Florence Phocas   +2 more
doaj   +1 more source

The role of accessory proteins and co-factors in regulation of melanocortin-4 receptor signalling: An update. [PDF]

J Neuroendocrinol
Jamaluddin A, McClellan A, Raffan E, Gorvin CM.   +3 more
europepmc   +1 more source

Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis. [PDF]

Int J Mol Sci
Ji RL, Zheng HS, Wilson AE, Tao YX.
europepmc   +1 more source

Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions. [PDF]

Cardiovasc Res
Guo DF, Williams PA, Olson A, Morgan DA, Herz H, Resch J, Atasoy D, Stauss HM, Sebag JA, Rahmouni K.   +9 more
europepmc   +1 more source

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences. [PDF]

J Poult Sci
Kimura K, Watanabe Y, Ashizawa S, Matsushita K, Nakao N, Ohta Y, Shiraishi JI.   +6 more
europepmc   +1 more source

A crucial role for novel miR-12137-3p in supporting weight gain in treatment naïve HIV-infected patients on antiretroviral therapies. [PDF]

J Transl Med
Majumdar N, Pokharel BR, Williams F, Rajput S, Cook PP, Akula SM.   +5 more
europepmc   +1 more source