Results 41 to 50 of about 1,970 (167)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

RoPE: A robust profile likelihood method for differential gene expression analysis

Genetic Epidemiology, Volume 47, Issue 5, Page 379-393, July 2023., 2023
Abstract Variation in RNA‐Seq data creates modeling challenges for differential gene expression (DE) analysis. Statistical approaches address conventional small sample sizes and implement empirical Bayes or non‐parametric tests, but frequently produce different conclusions. Increasing sample sizes enable proposal of alternative DE paradigms.
Lehang Zhong, Lisa J. Strug
wiley   +1 more source

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +1 more source

Pathophysiology of melanocortin receptors and their accessory proteins. [PDF]

, 2018
The melanocortin receptors (MCRs) and their accessory proteins (MRAPs) are involved in regulation of a diverse range of endocrine pathways. Genetic variants of these components result in phenotypic variation and disease. The MC1R is expressed in skin and
A.J.L. Clark, Anderson, Asai, Balthasar, Begriche, Benjannet, Bishop, Box, Buggy, Bultman, Butler, Butler, Böhm, Chakraborty, Chaly, Chan, Chan, Chan, Chen, Chen, Chen, Cheung, Chida, Chung, Chung, Clark, Clark, Clark, Clark, Coll, Collet, Cone, Cone, Cooray, Cooray, Cooray, Cui, D'Orazio, do Carmo, Elias, Enriori, Farooqi, Feng, Flier, Friedman, Gee, Ghamari-Langroudi, Girardet, Gonzalez-Rey, Gorrigan, Greenfield, Huszar, Jarrett, Kievit, Kim, L.F. Chan, Landi, Lee, Lee, Lembertas, Lim, Lovett, Lowry, Lu, Manceau, Markison, Marks, Marsh, Martinelli, Metherell, Metherell, Miller, Mirshahi, Morgan, Morgan, Morgan, Mountjoy, Mountjoy, Ni, Nimura, Novoselova, O'Rahilly, Ogawa, Ollmann, Padilla, Palmer, Pasquali, Pelleymounter, Raadsheer, Rached, Raimondi, Robbins, Robles-Espinoza, Rodrigues, Roselli-Rehfuss, Rouault, Roy, Schauer, Scott, Sebag, Sebag, Shen, Shenker, Simamura, Smith, Smith, Sohn, Srisai, Swords, T.V. Novoselova, Tao, Turan, Ulrich-Lai, Vaisse, Valverde, Vinson, Webb, Webb, Weber, Williams, Xu, Xu, Yang, Yeo, Young, Zhang, Zhang   +126 more
core   +2 more sources

MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation

Journal of Biological Chemistry, 2022
The melanocortin receptor accessory protein 2 (MRAP2) is essential for several physiological functions of the ghrelin receptor growth hormone secretagogue receptor 1a (GHSR1a), including increasing appetite and suppressing insulin secretion. In the absence of MRAP2, GHSR1a displays high constitutive activity and a weak G-protein-mediated response to ...
Alix A.J. Rouault, Paul Buscaglia, Julien A. Sebag   +2 more
openaire   +2 more sources

ACTH Antagonists. [PDF]

, 2016
Adrenocorticotropin (ACTH) acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors.
Attard, Beardwell, Biller, Boscaro, Bouw, Capatina, Chretien, Chung, Clark, Clark, Colao, Cooray, Cooray, Dores, Draper, Eberle, Fani, Feldhaus, Fridmanis, Goverde, Halem, Han, Hofmann, Hofmann, Joint LWPES/ESPE CAH Working Group, Juszczak, Keller-Wood, Kola, Kovalitskaia, Li, Liang, Lim, Lorimer, Lowry, Malik, Metherell, Miller, Mountjoy, Nensey, Nimkarn, Noon, Osborne, Peri, Pogozheva, Ramachandrappa, Ryan, Samuels, Schwyzer, Schwyzer, Schwyzer, Schöneshöfer, Sebag, Seelig, Seelig, Seferovic, Siepler, Singh, Sonino, Szalay, Veo, Verhelst, Webb, Yang, Zhu   +63 more
core   +6 more sources

Promiscuity among the MRAPs. [PDF]

, 2017
The melanocortin 2 receptor accessory protein (MRAP) was originally discovered to be an essential co-receptor for the ACTH receptor/melanocortin 2 receptor, and it physically interacts with this receptor and is required for receptor trafficking and ...
Chan, LF, Clark, AJL
core   +1 more source

Role of N-Linked Glycosylation in PKR2 Trafficking and Signaling

Frontiers in Neuroscience, 2021
Prokineticin receptors are GPCRs involved in several physiological processes including the regulation of energy homeostasis, nociception, and reproductive function.
Jissele A. Verdinez, Jissele A. Verdinez, Jissele A. Verdinez, Julien A. Sebag, Julien A. Sebag, Julien A. Sebag   +5 more
doaj   +1 more source

Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression [PDF]

, 2012
The progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) marks a critical step in the evolution of breast cancer. There is some evidence to suggest that dynamic interactions between the neoplastic cells and the tumour ...
A Rizki, A Rody, AH Beck, Amy E. McCart Reed, Ana Cristina Vargas, Annette Lane, C April, CC Ton, Chanel E. Smart, CM Heaphy, CS Schuetz, CW Elston, D Nonaka, E Dahl, F Courjal, F Ugolini, FA Tavassoli, G Finak, G Turashvili, Georgia Chenevix-Trench, GK Smyth, GS Delassus, H Fischer, H Fischer, H Kim, H Suzuki, HY Chang, J Hannemann, KB Bowen, KC Halsted, KJ Livak, L Mittempergher, Leonard da Silva, Lynne E. Reid, MA Lopez-Garcia, MG Kibriya, MM Reinholz, N Waddell, Nic Waddell, NP Castro, P Du, P Farmer, Peter T. Simpson, PT Simpson, RB West, Sarah Song, Sibylle Cocciardi, SR Lakhani, SR Wellings, Sunil R. Lakhani, T Krech, T Saeki, TR Webb, V Gelsi-Boyer, XJ Ma, XJ Ma, Y Gao, ZQ Yang   +57 more
core   +1 more source

G protein-coupled receptors: what a difference a 'partner' makes [PDF]

, 2014
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately,
Abu-Helo, Aiyar, Ardura, Attramadal, Babu, Baker, Bartlett, Behrens, Benovic, Benoît Roux, Bermak, Beuming, Björk, Bofill-Cardona, Bomberger, Bornert, Bouschet, Bradbury, Brady, Bretscher, Buck, Buhlmann, Bukau, Bécamel, Cabrera-Vera, Cai, Cao, Caron, Chabre, Chakraborty, Chan, Chen, Cheung, Christopoulos, Christopoulos, Chung, Claing, Clark, Clark, Clark, Colley, Cone, Cook, Cottrell, Cowen, Craig, Dackor, Dackor, Dores, Dunn, Dupré, Dupré, Dwyer, Décaillot, Egea, Ellgaard, Ellis, Evans, Evron, Fam, Ferguson, Ferreira, Fiedler, Fluhmann, Force, Fraser, Fredriksson, Gage, Gardner, Gerke, Gimelbrant, Girard, Goadsby, Graeme Cottrell, Gullapalli, Hamm, Han, Hay, Heydorn, Hilairet, Hilairet, Humrich, Jones, Kadmiel, Kadmiel, Kakiuchi, Kang, Kappeler, Kelley, Kennedy, Kjeldgaard, Kristiansen, Kuang, Kurten, Laburthe, Leclerc, Lee-Kwon, Levitt, Li, Lin, Lohse, Lu, Lucas, Luebke, Lukov, Lutz-Bucher, Ma, Mahon, Mahon, Mahon, Mai, Mancias, Marchese, Marenholz, McClintock, McClintock, McLatchie, Metherell, Miret, Montecucchi, Morello, Mountjoy, Muff, Murphy, Murrell, Málaga-Diéguez, Naghashpour, Nakajima, Nickols, Nikitenko, Nisar, Nishimura, Njuki, Noon, Noorwez, Oh, Oh, Okuse, Oliver, Overgaard, O’Neill, Paquet, Park, Parmentier, Petaja-Repo, Pfeffer, Pittman, Ponting, Prado, Premont, Pálfy, Ritter, Rivero-Müller, Rochdi, Roh, Romero, Rosenblatt, Saito, Sapolsky, Sarkar, Schmidt, Sebag, Sebag, Shenoy, Shieh, Simonin, Sorensen, Spehr, Stamnes, Strasser, Svenningsson, Svenningsson, Tan, Tsujikawa, Turner, Voeltz, Vos, Walther, Wang, Wang, Wang, Wang, Wang, Warner-Schmidt, Warner-Schmidt, Webb, Whistler, Wootten, Yamniuk, Yang, Zobiack   +190 more
core   +4 more sources