Results 21 to 30 of about 1,970 (167)

Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey [PDF]

Endocrine Connections, 2019
Melanocortin receptors (MCRs) and their accessory proteins (MRA Ps) evolutionarily first appear in the genome of sea lamprey. The most ancient melanocortin system consists of only two melanocortin receptors (slMCa and slMCb) and one MRAP2 (slMRAP2 ...
Ming Zhu, Bingxin Xu, Meng Wang, Shangyun Liu, Yue Zhang, Chao Zhang   +5 more
doaj   +3 more sources

Monogenic etiologies in a cohort of early onset obesity: a real-world experience from Belgium [PDF]

Frontiers in Endocrinology
IntroductionObesity is a major global health issue with multifactorial etiologies. Among them, recent advances in the comprehension of eating and energy regulation showed that around 60 genes involved in the hypothalamic leptin/melanocortin pathway ...
Julie Harvengt, Julie Harvengt, Muriel Hannon, Leonor Palmeira, Leonor Palmeira, Marie-Christine Lebrethon, Vinciane Dideberg, Vincent Bours, Vincent Bours   +8 more
doaj   +2 more sources

Feature genes identification and immune infiltration assessment in abdominal aortic aneurysm using WGCNA and machine learning algorithms [PDF]

Frontiers in Cardiovascular Medicine
ObjectiveAbdominal aortic aneurysm (AAA) is a life-threatening vascular condition. This study aimed to discover new indicators for the early detection of AAA and explore the possible involvement of immune cell activity in its development.MethodsSourced ...
Ming Xie, Xiandeng Li, Congwei Qi, Yufeng Zhang, Yufeng Zhang, Yufeng Zhang, Gang Li, Yong Xue, Guobao Chen   +8 more
doaj   +2 more sources

Syndecans modulate ghrelin receptor signaling. [PDF]

J Mol Endocrinol
Ghrelin is a gut hormone that enhances food intake and growth hormone secretion through its G-protein coupled receptor, the growth hormone secretagogue receptor (GHSR).
Prins K, Mutsters N, Volker F, Huisman M, Mies R, Delhanty PJD, Visser JA.   +6 more
europepmc   +3 more sources

Linking the Warburg effect to endometrial receptivity: metabolic parallels in embryo implantation [PDF]

Frontiers in Cell and Developmental Biology
IntroductionEndometrial receptivity (ER), critical for successful embryo implantation and a major limiting factor in infertility affecting ∼1 in 6 couples globally, remains poorly understood, with few effective interventions targeting the embryo ...
Xiaoyang Zhang, Qingwen Zhu, Weiduo Nie, Weiduo Nie, Xiaoxue Yan, Zhihua Yuan, Leiyu Tian   +6 more
doaj   +2 more sources

The role of accessory proteins and co-factors in regulation of melanocortin-4 receptor signalling: An update. [PDF]

J Neuroendocrinol
Abstract The melanocortin‐4 receptor (MC4R) is a G protein‐coupled receptor with an essential role in appetite suppression and energy homeostasis. Genetic mutations in the receptor and components of its signalling pathway that cause obesity in humans, dogs and rodent models have revealed important insights into how the receptor signals and what ...
Jamaluddin A, McClellan A, Raffan E, Gorvin CM.   +3 more
europepmc   +2 more sources

Mrap2: An Accessory Protein Linked to Obesity [PDF]

Cell Metabolism, 2013
Melanocortin receptors are critical modulators of energy balance and glucose homeostasis. Companion studies published in Science (Asai et al., 2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans.
Liu, Tiemin, Elmquist, Joel K., Williams, Kevin W.   +2 more
  +9 more sources

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons. [PDF]

Cell Biochem Funct
ABSTRACT The melanocortin‐3 receptor (MC3R) and the melanocortin‐4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in the MC4R gene represent the most common cause of monogenic obesity, the clinical significance of MC3R ...
Vos N, Moro A, Hul WV, Kleinendorst L, Florijn RJ, la Fleur SE, Verhage M, van Haelst MM, Toonen RF.   +8 more
europepmc   +2 more sources

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling

Frontiers in Endocrinology, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang, Song Xue, Xiaowei Lei, Wenqi Song, Lei Li, Xuan Li, Yanbin Fu, Cong Zhang, Hailin Zhang, Hailin Zhang, Yao Luo, Meng Wang, Gufa Lin, Gufa Lin, Chao Zhang, Jing Guo   +15 more
doaj   +1 more source

Identification of Regions Involved in the Physical Interaction between Melanocortin Receptor Accessory Protein 2 and Prokineticin Receptor 2

Biomolecules, 2022
Melanocortin Receptor Accessory Protein 2 (MRAP2) modulates the trafficking and signal transduction of several G-protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, such as Prokineticin receptors (PKRs).
Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Roberta Lattanzi, Rossella Miele   +4 more
doaj   +1 more source