Results 21 to 30 of about 1,450 (114)

Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus) [PDF]

General and Comparative Endocrinology, 2021
Abstract The melanocortin-5 receptor (MC5R) has been implicated in the regulation of exocrine gland secretion, immune regulation, and muscle fatty acid oxidation. However, its function in fish is not well established. Melanocortin-2 receptor accessory protein 2 (MRAP2) can modulate trafficking, ligand binding, and signaling of ...
Ti-Lin Yi, Ya-Xiong Tao, Ting Liu
exaly   +3 more sources

Monogenic etiologies in a cohort of early onset obesity: a real-world experience from Belgium [PDF]

Frontiers in Endocrinology
IntroductionObesity is a major global health issue with multifactorial etiologies. Among them, recent advances in the comprehension of eating and energy regulation showed that around 60 genes involved in the hypothalamic leptin/melanocortin pathway ...
Julie Harvengt, Julie Harvengt, Muriel Hannon, Leonor Palmeira, Leonor Palmeira, Marie-Christine Lebrethon, Vinciane Dideberg, Vincent Bours, Vincent Bours   +8 more
doaj   +2 more sources

Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia. [PDF]

PLoS Biology
The G protein-coupled receptor (GPCR) melanocortin receptor 4 (MC4R) is an essential regulator of body weight homeostasis. MC4R is unusual among GPCRs in that its activity is regulated by 2 opposing physiological ligands, the agonist ⍺-MSH and the ...
Irene Ojeda-Naharros, Tirthasree Das, Ralph A Castro, J Fernando Bazan, Christian Vaisse, Maxence V Nachury   +5 more
doaj   +2 more sources

Feature genes identification and immune infiltration assessment in abdominal aortic aneurysm using WGCNA and machine learning algorithms [PDF]

Frontiers in Cardiovascular Medicine
ObjectiveAbdominal aortic aneurysm (AAA) is a life-threatening vascular condition. This study aimed to discover new indicators for the early detection of AAA and explore the possible involvement of immune cell activity in its development.MethodsSourced ...
Ming Xie, Xiandeng Li, Congwei Qi, Yufeng Zhang, Yufeng Zhang, Yufeng Zhang, Gang Li, Yong Xue, Guobao Chen   +8 more
doaj   +2 more sources

Study of LEP, MRAP2 and POMC genes as potential causes of severe obesity in Brazilian patients

Eating and Weight Disorders, 2020
Monogenic forms of obesity are caused by single-gene variants which affect the energy homeostasis by increasing food intake and decreasing energy expenditure. Most of these variants result from disruption of the leptin-melanocortin signaling, which can cause severe early-onset obesity and hyperphagia.
Fonseca Acp, Giselda Cabello, Patricia Bozza   +2 more
exaly   +3 more sources

Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability [PDF]

BMC Genomics
Background Cryopreservation of porcine blastocysts remains a significant challenge due to their high lipid content, which can lead to cryoinjury and reduced developmental competence.
Jesse Oluwaseun Ayantoye, Baigao Yang, Jianhua Dong, Xiaoyi Feng, Muhammad Shahzad, Hubdar Ali Kolachi, Pengcheng Wan, Hongmei Pan, Xueming Zhao   +8 more
doaj   +2 more sources

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants

Cell Reports
Abstract Accessory proteins such as members of the melanocortin-2 receptor accessory protein family (MRAP) have been described to interact with and regulate the signaling of diverse G protein-coupled receptors (GPCRs), however, surprisingly little is known about the mechanisms by which they mediate these effects.
Jamaluddin A, Wyatt RA, Broichhagen J, Levitz J, Gorvin CM.   +4 more
europepmc   +5 more sources

Hypothesis and Theory: Revisiting Views on the Co-evolution of the Melanocortin Receptors and the Accessory Proteins, MRAP1 and MRAP2 [PDF]

Frontiers in Endocrinology, 2016
The evolution of the melanocortin receptors (MCRs) is closely associated with the evolution of the melanocortin-2 receptor accessory proteins (MRAPs). Recent annotation of the elephant shark genome project revealed the sequence of a putative MRAP1 ortholog.
Robert Dores
exaly   +3 more sources

9293 Do Obesity-Associated MRAP2 Variants Modulate MC4R and GHSR Signaling? [PDF]

J Endocr Soc
Abstract Disclosure: A.V. Rodriguez Rondon: None. F. Volker: None. M.S. Welling: None. C. de Groot: None. M.M. van Haelst: None. E.L. van den Akker: None. E.F. van Rossum: None. P.J. Delhanty: None. J.A. Visser: None. Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic ...
Rondon, Alejandra Virginia Rodriguez, Volker, Femke, Welling, Mila Sofie, de Groot, Corjan, van Haelst, Mieke M, van den Akker, Erica L T, van Rossum, Elisabeth F C, Delhanty, Patric John, Visser, Jenny A   +8 more
europepmc   +2 more sources

6789 Do Obesity-Associated MRAP2 Variants Modulate MC4R and GHSR Signaling? [PDF]

J Endocr Soc
Abstract Disclosure: A.V. Rodriguez Rondon: None. F. Volker: None. M.S. Welling: None. C. de Groot: None. M.M. van Haelst: None. E.L. van den Akker: None. E.F. van Rossum: None. P.J. Delhanty: None. J.A. Visser: None. Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic ...
Rondon, Alejandra Virginia Rodriguez, Volker, Femke, Welling, Mila Sofie, de Groot, Corjan, van Haelst, Mieke M, van den Akker, Erica L T, van Rossum, Elisabeth F C, Delhanty, Patric John, Visser, Jenny A   +8 more
europepmc   +2 more sources