Results 11 to 20 of about 1,450 (114)

The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells [PDF]

iScience, 2020
Summary: Ghrelin regulates both energy intake and glucose homeostasis. In the endocrine pancreas, ghrelin inhibits insulin release to prevent hypoglycemia during fasting.
Terry C. Yin, Casey J. Bauchle, Alix A.J. Rouault, Samuel B. Stephens, Julien A. Sebag   +4 more
doaj   +3 more sources

Cellular signatures of melanocortin pathway genes across the locus coeruleus [PDF]

Acta Neuropathologica Communications
Obesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD.
Alisha Basak, Fahrünisa Meryem Betül Erol, Maria Caterina De Rosa, Zhangji Dong, Victor Ogbolu, Hannah J. Glover, Rick Rausch, Gunnar Hargus, Jordi Creus-Muncunill, Heather Buchanan, Yu Bai, Qi Su, Betty Chang, Christina Adler, Delaney Flaherty, Benjamin Ciener, Harrison Xiao, Hasini Reddy, Pascaline Aime-Wilson, Christiane Reitz, Mark W. Sleeman, Judith Y. Altarejos, Rudolph L. Leibel, Liang Oscar Qiang, Andrew F. Teich, Claudia A. Doege   +25 more
doaj   +2 more sources

Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey [PDF]

Endocrine Connections, 2019
Melanocortin receptors (MCRs) and their accessory proteins (MRA Ps) evolutionarily first appear in the genome of sea lamprey. The most ancient melanocortin system consists of only two melanocortin receptors (slMCa and slMCb) and one MRAP2 (slMRAP2 ...
Ming Zhu, Bingxin Xu, Meng Wang, Shangyun Liu, Yue Zhang, Chao Zhang   +5 more
doaj   +3 more sources

Functional characterisation of obesity-associated MRAP2 variants on MC4R and GHSR signalling. [PDF]

Hum Mol Genet
Abstract Melanocortin-2 receptor accessory protein-2 (MRAP2) modulates the activity of hypothalamic melanocortin-4 (MC4R) and growth hormone-secretagogue (GHSR) receptors, which suppress and promote appetite, respectively. We investigate whether obesity-associated variants of MRAP2 alter their ability to modulate MC4R and GHSR ...
Rodríguez Rondón AV, Prins K, Volker F, van der Walle EEPL, de Groot CJ, van der Akker ELT, van Rossum EFC, van Haelst MM, Delhanty PJD, Visser JA.   +9 more
europepmc   +3 more sources

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R

JCI Insight, 2023
The G protein–coupled receptor melanocortin-4 receptor (MC4R) and its associated protein melanocortin receptor–associated protein 2 (MRAP2) are essential for the regulation of food intake and body weight in humans.
Adelaide Bernard, Irene Ojeda Naharros, Xinyu Yue, Francois Mifsud, Abbey Blake, Florence Bourgain-Guglielmetti, Jordi Ciprin, Sumei Zhang, Erin McDaid, Kellan Kim, Maxence V. Nachury, Jeremy F. Reiter, Christian Vaisse   +12 more
doaj   +5 more sources

Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure

Molecular Metabolism, 2018
Objective: Melanocortin 2 receptor accessory protein 2 (MRAP2) has a critical role in energy homeostasis. Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the phenotype of gross obesity ...
Li Chan, Sabrina Diano, Jung Dae Kim
exaly   +3 more sources

Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling

Biochimica Et Biophysica Acta - Molecular Cell Research, 2017
The Melanocortin Receptor Accessory Protein 2 (MRAP2) regulates the activity of several GPCRs involved in the control of food intake and energy expenditure. While MRAP2 was originally thought to exclusively interact with melanocortin receptors we have recently shown that it interacts with and inhibits the trafficking and signaling of the prokineticin ...
Julien A Sebag, Alix Rouault
exaly   +3 more sources

The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. [PDF]

Sci Signal
The central melanocortin system links nutrition to energy expenditure. Melanocortin-4 receptor (MC4R) controls appetite and food intake, and its signaling is potentiated by melanocortin-2 receptor accessory protein 2 (MRAP2). Human mutations in MC4R and MRAP2
Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM.   +8 more
europepmc   +4 more sources

Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy [PDF]

Current Issues in Molecular Biology
Genetic factors are key determinants in the pathophysiology of obesity, regulating energy homeostasis. Monogenic non-syndromic obesity accounts for 2–3% of obesity in both children and adults and is most often attributable to mutations in genes encoding ...
Giovanni Luppino, Mara Giordano, Francesca Franchina, Roberto Coco, Eleonora Inì, Carla Fazio, Debora Porri, Cecilia Lugarà, Domenico Corica, Tommaso Aversa, Malgorzata Wasniewska   +10 more
doaj   +2 more sources

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension [PDF]

Nature Medicine, 2019
The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor1. Although some MRAP2 mutations have been described in people with obesity1-3, their functional consequences on adiposity remain elusive.
Mehdi Derhourhi, Mathilde Boissel, François Pattou   +2 more
exaly   +6 more sources