Results 11 to 20 of about 1,970 (167)

MRAP2 regulates ghrelin receptor signaling and hunger sensing [PDF]

Nature Communications, 2017
Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Alix A J Rouault, Justin L Grobe,, Faha, Faps, Julien A Sebag   +2 more
exaly   +4 more sources

Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling

Biology, 2022
As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Meng Wang, Shen Qu, Chao Zhang
exaly   +5 more sources

MRAP2 Inhibits β-Arrestin-2 Recruitment to the Prokineticin Receptor 2 [PDF]

Current Issues in Molecular Biology
Melanocortin receptor accessory protein 2 (MRAP2) is a membrane protein that binds multiple G protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, including prokineticin receptors.
Roberta Lattanzi, Ida Casella, Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Rossella Miele   +5 more
doaj   +5 more sources

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R [PDF]

JCI Insight, 2023
The G protein–coupled receptor melanocortin-4 receptor (MC4R) and its associated protein melanocortin receptor–associated protein 2 (MRAP2) are essential for the regulation of food intake and body weight in humans.
Adelaide Bernard, Irene Ojeda Naharros, Xinyu Yue, Francois Mifsud, Abbey Blake, Florence Bourgain-Guglielmetti, Jordi Ciprin, Sumei Zhang, Erin McDaid, Kellan Kim, Maxence V. Nachury, Jeremy F. Reiter, Christian Vaisse   +12 more
doaj   +6 more sources

MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus) [PDF]

Biomolecules, 2021
The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of MC4R.
Zheng-Yong Wen, Ting Liu, Chuan-Jie Qin, Yuan-Chao Zou, Jun Wang, Rui Li, Ya-Xiong Tao   +6 more
doaj   +3 more sources

The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells [PDF]

iScience, 2020
Summary: Ghrelin regulates both energy intake and glucose homeostasis. In the endocrine pancreas, ghrelin inhibits insulin release to prevent hypoglycemia during fasting.
Terry C. Yin, Casey J. Bauchle, Alix A.J. Rouault, Samuel B. Stephens, Julien A. Sebag   +4 more
doaj   +3 more sources

Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol [PDF]

Journal of Endocrinology, 2016
Melanocortin receptor accessory protein 2 (MRAP2) is a transmembrane accessory protein predominantly expressed in the brain. Both global and brain-specific deletion of Mrap2 in mice results in severe obesity.
Chan, L., Chan, L., Clark, A., Clark, A., Coll, A., Coll, A., Gorrigan, R., Gorrigan, R., Guasti, L., Guasti, L., Larder, R., Larder, R., Lelliot, C., Lelliot, C., Logan, D., Logan, D., Novoselova, T., Novoselova, T., O'Rahilly, S., O'Rahilly, S., Rimmington, D., Rimmington, D., Sanger Mouse Genetics Project, T., Sanger Mouse Genetics Project, T., Tate, P., Tate, P., Wynn, E., Wynn, E.   +27 more
core   +10 more sources

The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. [PDF]

Sci Signal
The central melanocortin system links nutrition to energy expenditure. Melanocortin-4 receptor (MC4R) controls appetite and food intake, and its signaling is potentiated by melanocortin-2 receptor accessory protein 2 (MRAP2).
Jamaluddin A, Wyatt RA, Lee J, Dowsett GKC, Tadross JA, Broichhagen J, Yeo GSH, Levitz J, Gorvin CM.   +8 more
europepmc   +3 more sources

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology. [PDF]

Gene, 2020
Melanocortin-2 receptor accessory protein (MRAP) has an unusual dual topology and influences the expression, localisation, signalling and internalisation of the melanocortin receptor 2 (MC ); the adrenocorticotropic hormone (ACTH) receptor.
Adan, Agulleiro, Asai, Baron, Beaumont, Bruschetta, Caroline L. Smith, Catania, Catania, Chan, Chen, Chung, Clark, Clément, Dores, D’Aurora, Fagerberg, Fong, Gardiner, Getting, Gibbison, Gorrigan, Guran, Hughes, Imamine, Jain, Kim, Kühnen, Lee, Liang, Liu, Maben, Mandrika, Manna, Mao, Marsh, Metherell, Modan-Moses, Nasrin N.A. Berruien, Nimura, Novoselova, Novoselova, Ohno, Ollmann, Rouault, Rouault, Roy, Roy, Roy, Schonnop, Sebag, Sebag, Sebag, Sebag, Simonyan, Spiga, Srisai, Sánchez-Laorden, Valsalan, Venkatesh, Västermark, Wakamatsu, Webb, Xu, Zhang, Zhang   +65 more
core   +4 more sources

Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy [PDF]

Current Issues in Molecular Biology
Genetic factors are key determinants in the pathophysiology of obesity, regulating energy homeostasis. Monogenic non-syndromic obesity accounts for 2–3% of obesity in both children and adults and is most often attributable to mutations in genes encoding ...
Giovanni Luppino, Mara Giordano, Francesca Franchina, Roberto Coco, Eleonora Inì, Carla Fazio, Debora Porri, Cecilia Lugarà, Domenico Corica, Tommaso Aversa, Malgorzata Wasniewska   +10 more
doaj   +2 more sources