Results 81 to 90 of about 1,970 (167)

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation [PDF]

, 2018
Melanocortin 2 receptor accessory protein (MRAP) is a single transmembrane domain accessory protein and a critical component of the hypothamo-pituitary-adrenal axis.
Chan, L., Chan, L., Charalambous, M., Charalambous, M., Clark, A., Clark, A., Guasti, L., Guasti, L., Hussain, M., Hussain, M., King, P., King, P., Metherell, L., Metherell, L., Novoselova, T., Novoselova, T.   +15 more
core   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R

Journal of the Endocrine Society, 2020
Abstract Genetic studies in humans and mice have demonstrated that the Melanocortin 4 Receptor (MC4R) is essential for adequate regulation of food intake and body weight. MC4R is expressed in a small population of hypothalamic neurons and very little is known about its molecular and cellular dynamics in vivo.
Bernard, Adelaide A, Naharros, Irene Ojeda, Guglielmetti, Florence Bourgain, Yue, Xinyu, Vaisse, Christian   +4 more
openaire   +1 more source

9293 Do Obesity-Associated MRAP2 Variants Modulate MC4R and GHSR Signaling? [PDF]

J Endocr Soc
Abstract Disclosure: A.V. Rodriguez Rondon: None. F. Volker: None. M.S. Welling: None. C. de Groot: None. M.M. van Haelst: None. E.L. van den Akker: None. E.F. van Rossum: None. P.J. Delhanty: None. J.A. Visser: None. Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic ...
Rondon, Alejandra Virginia Rodriguez, Volker, Femke, Welling, Mila Sofie, de Groot, Corjan, van Haelst, Mieke M, van den Akker, Erica L T, van Rossum, Elisabeth F C, Delhanty, Patric John, Visser, Jenny A   +8 more
europepmc   +2 more sources

Genome‐wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract BACKGROUND People with Down syndrome (DS) overproduce amyloid‐beta (Aβ) due to triplication of the amyloid precursor protein (APP) gene on chromosome 21, and consequently accumulate brain amyloid load at younger ages. We conducted genome‐wide association (GWA) analyses on amyloid imaging and plasma biomarkers to discern the genetic ...
M. Muaaz Aslam, Lam‐Ha T. Dang, Ruyu Shi, Kang‐Hsien Fan, Asma Naseer Cheema, Laura Xicota, Danveet Minhas, Weiquan Luo, Narges Zafari, Vibha Acharya, Eleanor Feingold, Sharon Krinsky‐McHale, Charles M. Laymon, Ann Cohen, Benjamin L. Handen, Bradley T. Christian, Elizabeth Head, Mark E. Mapstone, Alzheimer's Biomarker Consortium – Down Syndrome (ABC‐DS), Joseph H. Lee, Carlos Cruchaga, M. Ilyas Kamboh   +21 more
wiley   +1 more source

Utilization of Bulk RNA Sequencing for the Evaluation of Keratin Nanomaterials as a Coating for Percutaneous Devices

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 3, March 2025.
ABSTRACT Despite advances in the design and protocols for maintaining the skin/device interface around percutaneous devices (PDs), no current strategy ensures the permanent attachment of peri‐implant epithelial tissue to the device surface. Based on preliminary data, we hypothesized that PDs coated with keratin nanomaterials, resembling the fingernail ...
Andrew Miller, James Peter Beck, Alexis White, Jayant Agarwal, Kent N. Bachus, Sujee Jeyapalina, Mark Van Dyke   +6 more
wiley   +1 more source

Astrocytes: New Targets of Melanocortin 4 Receptor Actions [PDF]

, 2013
Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss
Carniglia, Lila, Caruso, Carla Mariana, Durand, Daniela Elizabeth, Lasaga, Mercedes Isabel, Scimonelli, Teresa Nieves   +4 more
core   +1 more source

Identification of ARHGAP9 as a Key Diagnostic Marker for Abdominal Aortic Aneurysm by Multiomics and Experimental Validation

Human Mutation, Volume 2025, Issue 1, 2025.
Abdominal aortic aneurysm (AAA) is a serious vascular condition that significantly endangers the lives of patients. Although there have been improvements in early detection and treatment methods, considerable challenges persist regarding the timely identification and evaluation of risk associated with this disease.
Zhe Peng, Kun Li, Shile Wu, Baozhang Chen, Xiaonan Wang, Liang Chen, Xinsheng Wang, Hao Zhang, Biao Wu, Sujit Nair   +9 more
wiley   +1 more source

Genetic Landscape of Obesity in Children: Research Advances and Prospects

Journal of Obesity, Volume 2025, Issue 1, 2025.
Obesity is a chronic metabolic disease characterized by excessive accumulation or uneven distribution of fat in the body, which poses a serious threat to health. Obesity significantly increases the risk of developing сonditions such as type 2 diabetes, coronary heart disease, hypertension, obstructive sleep apnea, and some types of cancer.
Rita Khusainova, Ildar Minniakhmetov, Olga Vasyukova, Bulat Yalaev, Ramil Salakhov, Darya Kopytina, Raisat Guseinova, Ekaterina Dobreva, Galina Melnichenko, Ivan Dedov, Natalia Mokrysheva, Claire Stocker   +11 more
wiley   +1 more source

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants

Abstract Accessory proteins such as members of the melanocortin-2 receptor accessory protein family (MRAP) have been described to interact with and regulate the signaling of diverse G protein-coupled receptors (GPCRs), however, surprisingly little is known about the mechanisms by which they mediate these effects. MRAP2 modifies signaling of
Jamaluddin A, Wyatt RA, Broichhagen J, Levitz J, Gorvin CM.   +4 more
europepmc   +3 more sources