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A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice. [PDF]

J Clin Invest
Metzger PJ, Zhang A, Carlson BA, Sun H, Cui Z, Li Y, Jahnke MT, Layton DR, Gupta MB, Liu N, Kostenis E, Gavrilova O, Chen M, Weinstein LS.   +13 more
europepmc   +1 more source

Obesity: exploring its connection to brain function through genetic and genomic perspectives. [PDF]

Mol Psychiatry
Saeed S, Bonnefond A, Froguel P.
europepmc   +1 more source

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Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish

Journal of Cellular Physiology, 2021
AbstractThe melanocortin receptor accessory protein 2 (MRAP2) plays an essential role in the regulation of metabolic homeostasis and deletion of which results in severe obesity syndrome in mice and human. Mammalian MRAP2 is recognized as an endogenous physiological mediator through the potentiation of the MC4R signaling in vivo.
Chao Zhang, Meng Wang, Shaliu Fu
exaly   +3 more sources

MRAP2 regulates endometrial receptivity and function

Gene, 2019
A successful embryo implantation depends on the synchronization between a competent blastocyst and a receptive endometrium. Recently, potential modulators of endometrial receptivity (OVGP1, MRAP2, ZCCHC12, and HAP1) have been reported likely with a functional role during embryo implantation.
Francesca Diomede, Gian Mario Tiboni, Liborio Stuppia   +2 more
exaly   +4 more sources