Results 51 to 60 of about 49,162 (239)
Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations
The Journal of Dermatology, EarlyView.ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley +1 more source
Journal of Aging Research, 2011 The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7±3.7) women (65.6±2.8 yrs) randomized to either a control (𝑁=11) or ...
Tara M. Henagan +5 more
doaj +1 more source
Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy
eLife, 2017 Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension.
Michael J Litt +9 more
doaj +1 more source
Identification of novel GPCR partners of the central melanocortin signaling
Molecular Metabolism, 2021 Objective: Homo- or heterodimerization of G protein–coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo.
Yunpeng Li +13 more
doaj +1 more source
Andrology, EarlyView.Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre +5 more
wiley +1 more source
General and Comparative Endocrinology, 2013 The melanocortin system integrates different agonists, competitive or inverse agonists, and receptors. Recent investigations have also discovered a specific system of melanocortin receptor accessory proteins (MRAPs) that are involved in the regulation of the functional expression of these receptors.
Cerdá-Reverter, José Miguel +8 more
openaire +3 more sources
Inhibition of the central melanocortin system decreases brown adipose tissue activity[S]
Journal of Lipid Research, 2014 The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity.
Sander Kooijman +8 more
doaj +1 more source
Feeding induced by cannabinoids is mediated independently of the melanocortin system. [PDF]
PLoS ONE, 2008 Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss.
Puspha Sinnayah +9 more
doaj +1 more source
Specific Functions of Melanocortin 3 Receptor (MC3R)
JCRPE, 2023 Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date.
Tulin Yanik, Seyda Tugce Durhan
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HIV Medicine, EarlyView.Abstract Introduction Long‐acting injectable antiretroviral therapy (ART) with Cabotegravir (CAB) and Rilpivirine (RPV) offers an alternative to daily oral regimens, improving adherence and patient satisfaction. However, its impact on body composition and metabolism remains underexplored.
Andrea De Vito +13 more
wiley +1 more source