Results 71 to 80 of about 47,532 (196)

Dolutegravir population pharmacokinetics in racially, sex‐ and age‐diverse and antiretroviral therapy‐experienced adults with HIV in the United States

HIV Medicine, EarlyView.
Abstract Objectives Dolutegravir (DTG) has been associated with weight gain in women with HIV, Black people with HIV and people with HIV60 years. This study aimed to characterise DTG population pharmacokinetics (PopPK) in a diverse population including these sub‐populations.
Adrian Khoei, Andrew Edmonds, Yen Chang, Catalina Ramirez, Mackenzie Vogan, Amanda Poliseno, Steven Wolinsky, Ken Ho, Todd T. Brown, Joseph B. Margolick, Jacquett Batson, Jennifer Hoffmann, Mark A. Marzinke, Mirjam‐Colette Kempf, Maria L. Alcaide, Joffi Effoe, Cecile D. Lahiri, Igho Ofotokun, Anandi N. Sheth, Stephen Gange, Audrey L. French, Bani Tamraz, Bradley E. Aouizerat, Phyllis C. Tien, Seble G. Kassaye, Jack DeHovitz, Kathryn Anastos, Kara W. Chew, Michelle Floris‐Moore, Julie B. Dumond   +29 more
wiley   +1 more source

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

Frontiers in Pharmacology, 2018
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Noureldin Saleh, Noureldin Saleh, Gunnar Kleinau, Gunnar Kleinau, Nicolas Heyder, Nicolas Heyder, Timothy Clark, Peter W. Hildebrand, Peter W. Hildebrand, Peter W. Hildebrand, Patrick Scheerer, Patrick Scheerer   +11 more
doaj   +1 more source

Developmental Plasticity and Behavioural Evolution in Rodents: Insights From African Striped Mice (Rhabdomys)

Journal of Zoology, EarlyView.
Our review synthesizes how early‐life experiences shape behavioural development in rodents, drawing on developmental plasticity, non‐genetic inheritance and epigenetic mechanisms. Using African striped mice (Rhabdomys) and other small mammal systems as case studies, it presents an integrative framework linking parental care, developmental pathways and ...
N. Pillay, T. L. Rymer
wiley   +1 more source

Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes

BMC Evolutionary Biology, 2007
Background The melanocortin (MC) receptors have a key role in regulating body weight and pigmentation. They belong to the rhodopsin family of G protein-coupled receptors (GPCRs).
Kawauchi Hiroshi, Enberg Johan, Ringholm Aneta, Löwgren Maja, Takahashi Akiyoshi, Klovins Janis, Haitina Tatjana, Larson Earl T, Fredriksson Robert, Schiöth Helgi B   +9 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey

Endocrine Connections, 2019
Melanocortin receptors (MCRs) and their accessory proteins (MRA Ps) evolutionarily first appear in the genome of sea lamprey. The most ancient melanocortin system consists of only two melanocortin receptors (slMCa and slMCb) and one MRAP2 (slMRAP2 ...
Ming Zhu, Bingxin Xu, Meng Wang, Shangyun Liu, Yue Zhang, Chao Zhang   +5 more
doaj   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Setmelanotide in Bardet‐Biedl Syndrome: A Case Report

Pediatric Dermatology, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4‐receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet‐Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication.
Shelby Smith, Eric Sanfilippo, Lara Wine Lee   +2 more
wiley   +1 more source

Striking Suture Zone Mismatch Between Nuclear and Mitochondrial Markers in North African Chalcides ocellatus (Squamata: Scincidae)

Zoologica Scripta, EarlyView.
ABSTRACT Linnaean and Wallacean shortfalls remain pervasive even among common and widespread Mediterranean taxa, limiting our understanding of evolutionary history and species boundaries. The Ocellated Skink Chalcides ocellatus complex illustrates this issue, with disputed subspecific taxonomy and deep mitochondrial divergences across North Africa and ...
Paul Doniol‐Valcroze, Dave Lutgen, Menad Beddek, Boualem Dellaoui, Philippe Geniez, Olivier Peyre, Patricia Sourrouille, Pierre‐André Crochet   +7 more
wiley   +1 more source

Through the Sands of Time: Evolutionary History and Systematics of the Awl‐Headed Snakes (Colubridae: Lytorhynchus) in the Saharo‐Sindian Region

Zoologica Scripta, EarlyView.
ABSTRACT The psammophilous colubrid genus Lytorhynchus is widely distributed in the deserts of the Saharo‐Sindian region and adjacent areas. The taxonomy of the genus and the number of recognised species have remained unstable since the last taxonomic revision in 1970, with differing views on the taxonomic status of L. gaddi and L. kennedyi.
Lukáš Pola, Daniel Jablonski, Rafaqat Masroor, Bassam Abu Afifeh, Roberta Graboski, Mohammad Abu Baker, Zuhair S. Amr, Ahmed Mohajja AlShammari, Avrajjal Ghosh, Salvador Carranza, Jiří Šmíd   +10 more
wiley   +1 more source