Results 91 to 100 of about 47,532 (196)

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Convergent changes in melanocortin receptor 1 gene are associated with black-headed coat color in sheep. [PDF]

J Anim Sci, 2023
Zhou Q, Cao C, Zhang H, Liang Y, Zhang X, Kang Y, Fang W, Lan X, Li R, Pan C.   +9 more
europepmc   +1 more source

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li, Xiaotian Wang, Xin Liu, Shuping Wang, Wentao Yang   +4 more
wiley   +1 more source

Spiro-naphthyridine Antagonists of the Melanocortin Receptor 4 for the Treatment of Cachexia Associated with Chronic Illness. [PDF]

ACS Med Chem Lett, 2022
Rosse G.
europepmc   +1 more source

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. [PDF]

Neuropeptides, 2022
Eliason NL, Martin L, Low MJ, Sharpe AL.
europepmc   +1 more source

Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors. [PDF]

Cells, 2022
Wang M, Xu J, Lei XW, Zhang C, Liu SY, Jin LN, Zhang C.   +6 more
europepmc   +1 more source

When Macrocyclic Peptides Meet the Crystal Structure of a Melanocortin Receptor. [PDF]

J Med Chem, 2021
Grieco P.
europepmc   +1 more source

Identification of Regions Involved in the Physical Interaction between Melanocortin Receptor Accessory Protein 2 and Prokineticin Receptor 2. [PDF]

Biomolecules, 2022
Fullone MR, Maftei D, Vincenzi M, Lattanzi R, Miele R.   +4 more
europepmc   +1 more source

Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice. [PDF]

Front Immunol, 2022
Daini E, Vandini E, Bodria M, Liao W, Baraldi C, Secco V, Ottani A, Zoli M, Giuliani D, Vilella A.   +9 more
europepmc   +1 more source