Results 71 to 80 of about 49,162 (239)

Melanocortin receptors and their accessory proteins [PDF]

Molecular and Cellular Endocrinology, 2011
The melanocortin receptor family consists of 5 members which belong to the GPCR superfamily. Their specific ligands, the melanocortins are peptide hormones which are formed by the proteolytic cleavage of the proopiomelanocortin (POMC) protein. It is now recognised that certain GPCRs require accessory proteins for their function.
Cooray, Sadani N., Clark, Adrian J.L.
openaire   +3 more sources

Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes

BMC Evolutionary Biology, 2007
Background The melanocortin (MC) receptors have a key role in regulating body weight and pigmentation. They belong to the rhodopsin family of G protein-coupled receptors (GPCRs).
Kawauchi Hiroshi, Enberg Johan, Ringholm Aneta, Löwgren Maja, Takahashi Akiyoshi, Klovins Janis, Haitina Tatjana, Larson Earl T, Fredriksson Robert, Schiöth Helgi B   +9 more
doaj   +1 more source

Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota

Obesity, Volume 34, Issue 2, Page 372-381, February 2026.
ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Jane Shearer, Morris H. Scantlebury, Oghenefejiro Erome‐Utunedi, Anamika Choudhary, Jennifer A. Thompson, Christina Ohland, Kathy D. McCoy, Chunlong Mu   +7 more
wiley   +1 more source

Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey

Endocrine Connections, 2019
Melanocortin receptors (MCRs) and their accessory proteins (MRA Ps) evolutionarily first appear in the genome of sea lamprey. The most ancient melanocortin system consists of only two melanocortin receptors (slMCa and slMCb) and one MRAP2 (slMRAP2 ...
Ming Zhu, Bingxin Xu, Meng Wang, Shangyun Liu, Yue Zhang, Chao Zhang   +5 more
doaj   +1 more source

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches

Obesity, Volume 34, Issue 2, Page 417-427, February 2026.
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers, Zachary L. Brown, Noureen S. Khalil, Stephen B. Haigh, Mitchell A. Shivers, Tej V. Patel, Austin T. Joshua, Neal L. Weintraub, Scott A. Barman, Eric J. Belin de Chantemele, Sergei A. Kirov, David W. Stepp, David J. R. Fulton   +12 more
wiley   +1 more source

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

Frontiers in Pharmacology, 2018
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Noureldin Saleh, Noureldin Saleh, Gunnar Kleinau, Gunnar Kleinau, Nicolas Heyder, Nicolas Heyder, Timothy Clark, Peter W. Hildebrand, Peter W. Hildebrand, Peter W. Hildebrand, Patrick Scheerer, Patrick Scheerer   +11 more
doaj   +1 more source

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

From Permits to Samples: Addressing Key Challenges for High‐Quality Reference Genome Generation in Europe

Molecular Ecology Resources, Volume 26, Issue 2, February 2026.
ABSTRACT High‐quality reference genome assemblies have become essential for deepening our understanding of biodiversity, yet obtaining them for many species remains surprisingly challenging. Drawing on experiences from the European Reference Genome Atlas (ERGA) community, we focus on permit and sample‐handling procedures leading up to nucleic acid ...
Katja Reichel, Jaakko Pohjoismäki, Jonas J. Astrin, Astrid Böhne, Chiara Bortoluzzi, Elena Bužan, Javier del Campo, Claudio Ciofi, Camilla B. Di‐Nizo, Pradeep K. Divakar, Carola Greve, Vladimír Hampl, Leon Hilgers, Veronika N. Laine, Jennifer A. Leonard, Jesus Lozano‐Fernandez, Lada Lukić Bilela, Camila J. Mazzoni, Ann M. McCartney, José Melo‐Ferreira, Rita Monteiro, Rebekah A. Oomen, Martina Pavlek, João Pimenta, Michal Rindos, Ole Seehausen, Andrii Tarieiev, Salvatore Tomasello, Olga Vinnere Pettersson, Robert M. Waterhouse, Alexandra A.‐T. Weber, Oleksandr Zinenko, Christian de Guttry   +32 more
wiley   +1 more source

Melanocortin 1 Receptor: Structure, Function and Regulation

Frontiers in Genetics, 2016
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell, Mary Catherine Boulanger, John August D'orazio   +2 more
doaj   +1 more source

Distinct binding and signaling activity of Acthar Gel compared to other melanocortin receptor agonists [PDF]

, 2020
Ying-Su Huang, Karen P. Galen, Ben S. Zweifel, Leah R. Brooks, Albion D. Wright   +4 more
openalex   +1 more source