Results 111 to 120 of about 1,543 (156)

Brain effects of melanocortins☆

Pharmacological Research, 2009
The melanocortins (alpha, beta and gamma-melanocyte-stimulating hormones: MSHs; adrenocorticotrophic hormone: ACTH), a family of pro-opiomelanocortin (POMC)-derived peptides having in common the tetrapeptide sequence His-Phe-Arg-Trp, have progressively revealed an incredibly wide range of extra-hormonal effects, so to become one of the most promising ...
Anna Valeria Vergoni, Alfio Bertolini
exaly   +3 more sources

Melanocortins and reproduction

Brain Research Reviews, 2002
Obesity, anorexia and general body weight fluctuations cause a variety of effects on the reproductive system. Our understanding of the neuro-biological mechanisms of the connections between body weight and the reproductive axis is not especially developed despite a number of interesting physiological observations.
Helgi B, Schiöth, Hajime, Watanobe
openaire   +2 more sources

The melanocortin system

American Journal of Physiology-Endocrinology and Metabolism, 2003
The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four ...
Ira, Gantz, Tung M, Fong
openaire   +2 more sources

Melanocortins and cardiovascular regulation

European Journal of Pharmacology, 1998
The melanocortins form a family of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common. Melanocortins have been described as having a variety of cardiovascular effects. We review here what is known about the sites and mechanisms of action of the melanocortins with respect to
D H, Versteeg, P, Van Bergen, R A, Adan, D J, De Wildt   +3 more
openaire   +2 more sources

Melanocortins and their implication in melanoma

Trends in Endocrinology & Metabolism, 1995
The melanocortins (MCs), that is, the melanocyte-stimulating hormones (MSHs) and ACTH, are a group of related peptides containing the typical melanotropin core sequence, His-Phe-Arg-Trp, and are derived from a common precursor, pro-opiomelanocortin.
W, Siegrist, A N, Eberle
openaire   +2 more sources

Characterization of Melanocortin Receptors

Current Protocols in Pharmacology, 2003
AbstractThis unit describes a Scintillation Proximity Assay (SPA) for the measurement of ligand binding to melanocortin receptors (MCRs) using membranes prepared from cell lines stably expressing recombinant MCRs. It provides a facile method for determining the affinity of compounds at MC1R, MC3R, MC4R, or MC5R.
Aaron S, Goetz, Diane M, Ignar
openaire   +2 more sources

Melanocortin Signalling Mechanisms

2010
The melanocortin family are a series of very potent neuropeptides that derive from a parent propopiomelanocortin molecule (POMC). They are expressed predominantly in the brain, specifically the pituitary gland and also in the central nervous system. Interestingly, recent research also suggests the existence of regulatory functions outside of the brain,
Paula Eves, J. W. Haycock
openaire   +3 more sources

Evolution of the melanocortin system

General and Comparative Endocrinology, 2014
The melanocortin system is one of the most complex of the hormonal systems. It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs ...
Cortés, Raúl, Navarro, Sandra, Agulleiro Gozalbo, Maria Josep, Guillot, Raúl, García-Herranz, Víctor, Sánchez Martínez, Elisa, Cerdá-Reverter, José Miguel   +6 more
openaire   +3 more sources

Melanocortins and their Receptors and Antagonists

Current Drug Targets, 2003
The melanocortins are a group of small protein hormones derived by post-translational cleavage of the proopiomelanocortin (POMC) gene product. The known melanocortin hormones include alpha-melanocyte stimulating hormone (MSH), beta-MSH, gamma-MSH and adrenocorticotropic hormone (ACTH).
Voisey, J, Carroll, L, van Daal, A
openaire   +3 more sources

Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes

2010
The melanocortins (MC) are released from neurons and paracrine cells in the CNS where they are involved in important physiological functions, including regulation of body temperature and immune responses. MC bind to melanocortin receptors, a class of cell surface G-protein-coupled receptors. Of the five subtypes of MC receptors that have been cloned in
Ruta, Muceniece, Maija, Dambrova
openaire   +2 more sources