Results 91 to 100 of about 3,506 (222)

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Melanocortins and opiate addiction

Life Sciences, 1997
Adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone (alpha-MSH) are centrally acting melanocortin peptides with numerous reported functions, including induction of excessive grooming and antipyresis, among others. Also reported is a role for melanocortins in aspects of opiate action.
J D, Alvaro, J B, Tatro, R S, Duman
openaire   +2 more sources

Subcutaneous repository corticotropin gel for non-infectious panuveitis: Reappraisal of an old pharmacologic agent

American Journal of Ophthalmology Case Reports, 2016
Purpose: To describe the clinical course of a patient with non-infectious idiopathic unilateral panuveitis and retinal vasculitis treated with subcutaneous repository adrenocorticotropic hormone (ACTH) gel. Observations: A 33-year-old male presented with
Aniruddha Agarwal, Muhammad Hassan, Yasir J. Sepah, Diana V. Do, Quan Dong Nguyen   +4 more
doaj   +1 more source

Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea

JPGN Reports, Volume 7, Issue 2, Page 242-246, May 2026.
Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno, Angelo Corso Faini, Silvia Deaglio, Marianna Pellegrini, Raffaele Buganza, Francesca Giuliani, Pier Luigi Calvo, Michele Pinon   +7 more
wiley   +1 more source

Novel α-MSH peptide analogues with broad spectrum antimicrobial activity.

PLoS ONE, 2013
Previous investigations indicate that α-melanocyte-stimulating hormone (α-MSH) and certain synthetic analogues of it exert antimicrobial effects against bacteria and yeasts.
Paolo Grieco, Alfonso Carotenuto, Luigia Auriemma, Antonio Limatola, Salvatore Di Maro, Francesco Merlino, Maria Luisa Mangoni, Vincenzo Luca, Antonio Di Grazia, Stefano Gatti, Pietro Campiglia, Isabel Gomez-Monterrey, Ettore Novellino, Anna Catania   +13 more
doaj   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance

Molecular Metabolism
Hypothalamic neurons expressing either POMC or AGRP sense nutritional state directly and indirectly and transmit these neuropeptide signals to other brain centres through the melanocortin 3 and 4 receptors. MC4R is primarily concerned with the control of
Katie Duckett, Alyce McClellan, Laura J. Corbin, Irene Cimino, Ahmed Elhakeem, Ana Goncalves Soares, Alice Williamson, Eloise Cross, Zammy Fairhurst-Hunter, Slavé Petrovski, Debra Rimmington, Jesús Alegre-Díaz, Jaime Berumen, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jacek Mokrosinski, I. Sadaf Farooqi, Asif Rasheed, Danish Saleheen, Adam S. Butterworth, Nicholas J. Timpson, Anthony P. Coll, Eleanor Raffan, Brian Y.H. Lam, Stephen O’Rahilly   +24 more
doaj   +1 more source

Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides

International Journal of Inflammation, 2013
The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution and anti-inflammatory effects
Tazeen J. Ahmed, Trinidad Montero-Melendez, Mauro Perretti, Costantino Pitzalis   +3 more
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Early life origins of metabolic disease: Developmental programming of hypothalamic pathways controlling energy homeostasis. [PDF]

, 2015
A wealth of animal and human studies demonstrate that perinatal exposure to adverse metabolic conditions - be it maternal obesity, diabetes or under-nutrition - results in predisposition of offspring to develop obesity later in life.
Dearden, Laura, Ozanne, Susan E
core   +2 more sources