Results 1 to 10 of about 190,071 (238)

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance. [PDF]

Mol Metab, 2018
Objective: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance ...
Mountjoy KG, Caron A, Hubbard K, Shome A, Grey AC, Sun B, Bould S, Middleditch M, Pontré B, McGregor A, Harris PWR, Kowalczyk R, Brimble MA, Botha R, Tan KML, Piper SJ, Buchanan C, Lee S, Coll AP, Elmquist JK.   +19 more
europepmc   +5 more sources

Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma. [PDF]

J Transl Med, 2023
Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specific expression and involvement in melanocyte ...
Dall'Olmo L, Papa N, Surdo NC, Marigo I, Mocellin S.   +4 more
europepmc   +3 more sources

Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. [PDF]

Front Pharmacol, 2018
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq-coupling.
Nepomuceno D, Kuei C, Dvorak C, Lovenberg T, Liu C, Bonaventure P.   +5 more
europepmc   +4 more sources

Alpha-Melanocyte-Stimulating Hormone Maintains Retinal Homeostasis after Ischemia/Reperfusion. [PDF]

Biomolecules
Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes protects the retinas from degeneration. The retinal cells are protected from oxidative and apoptotic signals of death.
Ng TF, Cho JY, Zhao JL, Gardiner JR, Wang ES, Leung E, Xu Z, Fineman SL, Lituchy M, Lo AC, Taylor AW.   +10 more
europepmc   +2 more sources

Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide. [PDF]

Mol Metab
Objective: During infection, metabolism and immunity react dynamically to promote survival through mechanisms that remain unclear. Pro-opiomelanocortin (POMC) cleavage products are produced and released in the brain and in the pituitary gland.
Reynolds RP, Fan RR, Tinajero A, Luo X, Huen SC, Fujikawa T, Lee S, Lemoff A, Mountjoy KG, Elmquist JK.   +9 more
europepmc   +2 more sources

Syringaresinol Attenuates α-Melanocyte-Stimulating Hormone-Induced Reactive Oxygen Species Generation and Melanogenesis. [PDF]

Antioxidants (Basel)
Ginseng has been utilized for centuries in both the medicinal and cosmetic realms. Recent studies have actively investigated the biological activity of ginseng berry and its constituents. (+)-Syringaresinol [(+)-SYR], an active component of ginseng berry,
Kim K, Yoon J, Lim KM.
europepmc   +2 more sources

The alpha-melanocyte stimulating hormone is related to heart rate during exercise recovery. [PDF]

Heliyon, 2020
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a part of the hormonal stress system with proven cardiovascular effects. Heart rate recovery (HRR) following exercise is strongly correlated to overall fitness and future adverse cardiovascular events ...
Popovic D, Popovic B, Seman S, Labudovic D, Lasica R, Jakovljevic DG, Arena R, Damjanovic SS.   +7 more
europepmc   +2 more sources

Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone [PDF]

PeerJ, 2018
The blood–brain barrier (BBB), an interface between the systemic circulation and the nervous system, can be a target of cytokines in inflammatory conditions.
András Harazin, Alexandra Bocsik, Lilla Barna, András Kincses, Judit Váradi, Ferenc Fenyvesi, Vilmos Tubak, Mária A. Deli, Miklós Vecsernyés   +8 more
openalex   +3 more sources

Anti-inflammatory α-Melanocyte-Stimulating Hormone Protects Retina After Ischemia/Reperfusion Injury in Type I Diabetes. [PDF]

Front Neurosci, 2022
Retinal ischemia/reperfusion (I/R) injury is a major cause of vision loss in many ocular diseases. Retinal I/R injury is common in diabetic retinopathy, which as a result of hyperglycemia damages the retina and can cause blindness if left untreated ...
Goit RK, Taylor AW, Lo ACY.
europepmc   +2 more sources

α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation. [PDF]

Physiol Rep, 2022
Oxytocin is secreted into the periphery by magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei (SON and PVN) to trigger uterine contraction during birth and milk ejection during suckling.
Perkinson MR, Kirchner MK, Zhang M, Augustine RA, Stern JE, Brown CH.   +5 more
europepmc   +2 more sources