Results 91 to 100 of about 188,005 (273)

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Schmidt's Syndrome: An Uncommon Cause of Spontaneous Hypoglycemia

Avicenna Journal of Medicine
Schmidt's syndrome, or autoimmune polyendocrine syndrome type 2 (APS-2), is an uncommon disorder characterized by the co-occurrence of autoimmune thyroiditis and adrenalitis.
George Sarin Zacharia, Anu Jacob, Binu Mary Bose   +2 more
doaj   +1 more source

Evaluation of the Hypothalamus‐Hypophysis‐Adrenal Axis in Male Rats Programmed by Gestational Protein Restriction

Cell Biochemistry and Function, Volume 43, Issue 10, October 2025.
ABSTRACT Diet manipulations during the gestation of animal models, in this case, the lipoprotein diet, mimic the alterations related to low birth weight, providing studies of the mechanisms involved in chronic disease development in later life. Our research group identified in adult male rats submitted to gestational protein restriction, increased ...
Vinicius Schiavinatto Mariano, José Antonio Rocha Gontijo, Patrícia Aline Boer   +2 more
wiley   +1 more source

An α-Melanocyte–Stimulating Hormone Analogue in Erythropoietic Protoporphyria

New England Journal of Medicine, 2009
To the Editor: Patients with erythropoietic protoporphyria, a rare inherited disease, accumulate photosensitizing protoporphyrin in the dermis, which results in severe dermal pain and incapacitating phototoxic reactions when the skin is exposed to visible light, primarily blue light (the Soret band, with the strongest absorbance among the porphyrins).1
Harms, J, Lautenschlager, S, Minder, C E, Minder, E I   +3 more
openaire   +4 more sources

Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting GnRH‐1 Migration

Glia, Volume 73, Issue 10, Page 2077-2097, October 2025.
Main Points OECs, SCs, and Mel derive from SCPs. Sox10Cre;YapHet;TazKO mice show impaired SC maturation, reduced Mel formation, fewer SCPs, OECs, and olfactory neurons, but normal GnRH‐1 neuron migration. ABSTRACT Olfactory Ensheathing Cells (OECs) are glial cells originating from the neural crest and are critical for bundling olfactory axons to the ...
Ed Zandro M. Taroc, Enrico Amato Jr., Alexis M. Semon, Nikki Dolphin, Briane Beck, Sophie Belin, Yannick Poitelon, Paolo E. Forni   +7 more
wiley   +1 more source

Advances in the management of erythropoietic protoporphyria – role of afamelanotide

The Application of Clinical Genetics, 2016
Ashley M Lane,1 Jerome T McKay,2 Herbert L Bonkovsky1 1Department of Internal Medicine, Section on Gastroenterology; 2Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC, USAAbstract ...
Lane AM, McKay JT, Bonkovsky HL
doaj  

Melanocyte-stimulating hormone—mimetic action of the phenothiazines

Journal of Pharmacy and Pharmacology, 1978
AbstractWe have compared the melanophore-stimulating action of four phenothiazines, trifluoperazine, perphenazine, chlorpromazine, and prochlorperazine, with α-MSH on the skin of the lizard Anolis carolinensis, using a new rate method of bioassay. The dose-response curves for the phenothiazines were parallel to that of α-MSH, and when given together α ...
Sam Shuster, R. J. Carter
openaire   +3 more sources

Epidermal Keratinocyte Cells in Laboratory, Clinical Trials, and Market: A Narrative Review

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims The skin serves essential protective and regulatory functions. In severe injuries such as burns, keratinocytes—being the main epidermal cells—play a pivotal role in skin regeneration through secretion of growth factors and cytokines.
Sona Zare, Alireza Jafarzadeh, Solmaz Zare, Mohammad Ali Nilforoushzadeh, Amir Shamloo   +4 more
wiley   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
wiley   +1 more source

Correlation study of facial lipid profile differences and skin physiological characteristics in Chinese women aged 19–33 years

International Journal of Cosmetic Science, Volume 47, Issue 5, Page 752-767, October 2025.
The facial SC lipid profiles of young Chinese women in the early aging stage exhibited significant changes with age. The average chain length of diacylglycerol, triacylglycerol and short‐chain ceramides decreases with age, while the cholesteryl ester and ceramide EO subclasses increase. Some ceramides correlate positively with TEWL, skin elasticity and
Yumei Fan, Chunhua Wei, Ning Su, Yanyun Ma, Wei Liu, Peiwen Sun, Shuo Shan   +6 more
wiley   +1 more source