Results 11 to 20 of about 188,005 (273)

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance [PDF]

Molecular Metabolism, 2018
Objective: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance ...
Kathleen G. Mountjoy, Alexandre Caron, Kristina Hubbard, Avik Shome, Angus C. Grey, Bo Sun, Sarah Bould, Martin Middleditch, Beau Pontré, Ailsa McGregor, Paul W.R. Harris, Renata Kowalczyk, Margaret A. Brimble, Rikus Botha, Karen M.L. Tan, Sarah J. Piper, Christina Buchanan, Syann Lee, Anthony P. Coll, Joel K. Elmquist   +19 more
doaj   +8 more sources

Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro [PDF]

Frontiers in Pharmacology, 2018
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq-coupling.
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure   +5 more
doaj   +3 more sources

Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma [PDF]

Journal of Translational Medicine, 2023
Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specific expression and involvement in melanocyte ...
Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo, Simone Mocellin   +4 more
doaj   +2 more sources

The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]

PLoS ONE, 2010
BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser, Thomas Brzoska, Vinzenz Oji, Matteo Auriemma, Maik Voskort, Verena Kupas, Lars Klenner, Cornelius Mensing, Axel Hauschild, Stefan Beissert, Thomas A Luger   +10 more
doaj   +2 more sources

Alpha-Melanocyte-Stimulating Hormone Maintains Retinal Homeostasis after Ischemia/Reperfusion [PDF]

Biomolecules
Augmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes protects the retinas from degeneration. The retinal cells are protected from oxidative and apoptotic signals of death.
Tat Fong Ng, Jenna Y. Cho, John L. Zhao, John R. Gardiner, Eric S. Wang, Elman Leung, Ziqian Xu, Samantha L. Fineman, Melinda Lituchy, Amy C. Lo, Andrew W. Taylor   +10 more
doaj   +2 more sources

MicroRNA-141-3p and microRNA-200a-3p regulate α-melanocyte stimulating hormone-stimulated melanogenesis by directly targeting microphthalmia-associated transcription factor. [PDF]

Sci Rep, 2020
In recent years, it has been reported that non-coding RNAs, especially microRNAs (miRNAs) and long non-coding RNAs, act as melanogenesis-regulating molecules in melanocytes. We found that the expression levels of miR-141-3p and miR-200a-3p were decreased
Itoh T, Fukatani K, Nakashima A, Suzuki K.   +3 more
europepmc   +2 more sources

Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide [PDF]

Molecular Metabolism
Objective: During infection, metabolism and immunity react dynamically to promote survival through mechanisms that remain unclear. Pro-opiomelanocortin (POMC) cleavage products are produced and released in the brain and in the pituitary gland.
R.P. Reynolds, R.R. Fan, A. Tinajero, X. Luo, S.C. Huen, T. Fujikawa, S. Lee, A. Lemoff, K.G. Mountjoy, J.K. Elmquist   +9 more
doaj   +2 more sources

Syringaresinol Attenuates α-Melanocyte-Stimulating Hormone-Induced Reactive Oxygen Species Generation and Melanogenesis [PDF]

Antioxidants
Ginseng has been utilized for centuries in both the medicinal and cosmetic realms. Recent studies have actively investigated the biological activity of ginseng berry and its constituents. (+)-Syringaresinol [(+)-SYR], an active component of ginseng berry,
Kyuri Kim, Jihyun Yoon, Kyung-Min Lim
doaj   +2 more sources

The alpha-melanocyte stimulating hormone is related to heart rate during exercise recovery [PDF]

Heliyon, 2020
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a part of the hormonal stress system with proven cardiovascular effects. Heart rate recovery (HRR) following exercise is strongly correlated to overall fitness and future adverse cardiovascular events ...
Dejana Popovic, Bojana Popovic, Stefan Seman, Dragana Labudovic, Ratko Lasica, Djordje G. Jakovljevic, Ross Arena, Svetozar S. Damjanovic   +7 more
doaj   +2 more sources

Effect of 3,6-anhydro-l-galactose on α-melanocyte stimulating hormone-induced melanogenesis in human melanocytes and a skin-equivalent model. [PDF]

J Cell Biochem, 2018
3,6‐Anhydro‐l‐galactose (l‐AHG) is a bioactive sugar that is a major component of agarose. Recently, l‐AHG was reported to have anti‐melanogenic potential in human epidermal melanocytes (HEMs) and B16F10 melanoma cells; however, its underlying molecular ...
Kim JH, Kim DH, Cho KM, Kim KH, Kang NJ.
europepmc   +2 more sources