Results 11 to 20 of about 11,497 (72)

The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Is Critically Involved in the Development of Cytotoxic CD8+ T Cells in Mice and Humans [PDF]

, 2010
BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Axel Hauschild, Cornelius Mensing, Derya Unutmaz, Karin Loser, Lars Klenner, Maik Voskort, Matteo Auriemma, Stefan Beissert, Thomas A. Luger, Thomas Brzoska, Verena Kupas, Vinzenz Oji   +11 more
core   +7 more sources

Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]

, 2016
Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio, Burnett, Arthur L., Corona, Giovanni, Isidori, Andrea, Maggi, Mario   +4 more
core   +1 more source

Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]

, 2018
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar, Detering, Lisa, Liu, Yongjian, Luehmann, Hannah, Pang, Bo, Sultan, Deborah, Xia, Younan, Yang, Miaoxin, Zhao, Yongfeng   +8 more
core   +2 more sources

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway [PDF]

, 2009
Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Abdel-Malek, Aberdam, Barsh, Bennett, Bennett, Bennett, Bertolotto, Buffey, Candille, Clément, Costin, Duhl, Englaro, Eves, Friedmann, García-Borrón, Graham, He, He, Hirobe, Ito, Ito, Ito, Ito, Jimbow, Land, Le Pape, Le Pape, Levy, McNulty, Millar, Mountjoy, Ollmann, Ozeki, Park, Robbins, Sakai, Sanchez-Mas, Slominski, Smalley, Sviderskaya, Sviderskaya, Sviderskaya, Sviderskaya, Tsatmali, Wakamatsu   +45 more
core   +2 more sources

Modulation of social behavior by the agouti pigmentation gene [PDF]

, 2014
Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle.
Carola V, Gross CT, Novotny MV, Perlas E, Soini HA, Zonfrillo F   +5 more
core   +1 more source

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods [PDF]

, 2015
The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors.Sexual dimorphism of this axis has been described in different species under physiological conditions and it hasbeen proposed that sexual hormones could have ...
Cabrera Battler, M. F., Castillo, V, A., Gallelli, María Florencia, Gomez, N. V., Meikle, A., Miceli, Diego Daniel, Monachesi, N.   +6 more
core   +1 more source

Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism [PDF]

, 2012
Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation.
Abraham, Ackermann, Ang Li, Balch, Balch, Bauer, Buccione, Cook, Demunter, Downward, Edward, Fuchs, Furmaniak-Kazmierczak, Gray-Schopfer, Hancock, Hendrix, Hirobe, Jaffe, Karen Blyth, Karreth, Kelsh, Kissil, Kunisada, Larue, Laura M. Machesky, Li, Li, Linder, Lionel Larue, Luciani, Mackenzie, Malumbres, Marshall, McCalmont, Meng Jin, Mishra, Mort, Nakahara, Owen J. Sansom, Peters, Platz, Qiu, Richard L. Mort, Sahai, Samuel, Scott, Sharov, Susan Mason, Vidali, Whitwam, Yafeng Ma, Yamaguchi, Yang   +52 more
core   +1 more source

Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. [PDF]

, 2012
Basal cell carcinoma (BCC) incidence is increasing, particularly among adults under the age of 40 years. Pigment-related characteristics are associated with BCC in older populations, but epidemiologic studies among younger individuals and analyses of ...
Allen E. Bale, American Cancer Society, Annette M. Molinaro, Arits, Bakos, Bastiaens, Bath-Hextall, Birch-Johansen, Box, Box, Boyd, Brenda Cartmel, Christenson, David J. Leffell, Dessinioti, Doherty, Dwyer, Eves, Flohil, Getting, Gorlin, Gudbjartsson, Han, Hogan, Housman, Ichii-Jones, International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer, Kanetsky, Kanetsky, Karagas, Kennedy, Kiiski, Koppula, Landi, Leah M. Ferrucci, Levi, Liboutet, Madan, Maia, Naldi, Nan, Naysmith, Palmer, Patricia B. Gordon, Robinson, Rogers, Scherer, Scherer, Smith, Stacey, Susan T. Mayne, Valverde, Vitasa, Zanetti   +53 more
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Evidence for variable selective pressures at MC1R [PDF]

, 2000
It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date,the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance inhuman pigmentation. Here we
Birch-Machin, Mark A, Dixon, Craig, Ellis, N. S., Flanagan, Niamh, Harding, Rosalind M., Healy, Eugene, Jackson, Ian, Ray, Amanda, Rees, Jonathan, Sajantila, Antti, Todd, Carole   +10 more
core   +2 more sources

Participation of the Melanocortin-1 Receptor in the UV Control of Pigmentation [PDF]

, 1999
The cloning of the melanocortin-1 receptor (MC1R) gene from human melanocytes and the demonstration that these cells respond to the melanocortins α-melanocyte stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH) with increased proliferation
Abdel-Malek, Zalfa, Akcali, Can, Barsh, Greg, Davis, Mary Beth, Hearing, Vincent, Im, Sungbin, Scott, Cathy, Suzuki, Itaru, Tada, Akihiro   +8 more
core   +1 more source