Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling. [PDF]
, 2014 Long-wave UVA is the major component of terrestrial UV radiation and is also the predominant constituent of indoor sunlamps, both of which have been shown to increase cutaneous melanoma risk.
Rajadurai, A +4 more
core +2 more sources
Neprilysin, a Novel Target for Ultraviolet B Regulation of Melanogenesis Via Melanocortins [PDF]
, 2000 SummaryCompelling evidence suggest a role for melanocortins in the regulation of melanogenesis by ultraviolet radiation. Within the epidermis, melanocytes and keratinocytes produce α-melanocyte-stimulating hormone and adrenocorticotropic hormone.
Aberdam, Edith +3 more
core +1 more source
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
core +1 more source
Melanocortin 1 Receptor Variants in an Irish Population [PDF]
, 1998 The identification of an association between variants in the human melanocortin 1 receptor (MC1R) gene and red hair and fair skin, as well as the relation between variants of this gene and coat color in animals, suggests that the MC1R is an integral ...
Birch-Machin, Mark A. +11 more
core +2 more sources
Expression of Proopiomelanocortin, Corticotropin-Releasing Hormone (CRH), and CRH Receptor in Melanoma Cells, Nevus Cells, and Normal Human Melanocytes [PDF]
, 1999 Proopiomelanocortin (POMC) is a 31kDa prohormone that is processed to various bioactive peptides, including adrenocorticotropin (ACTH), melanotropins (α, β, γ-MSH), lipotropins, and endorphins.
Chakraborty, Ashok K. +5 more
core +1 more source
Camptothecin-Loaded Liposomes with α-Melanocyte-Stimulating Hormone Enhance Cytotoxicity Toward and Cellular Uptake by Melanomas: An Application of Nanomedicine on Natural Product [PDF]
, 2013 In this study, we attempted to develop functional liposomes loaded with camptothecin and attached to α-melanocyte-stimulating hormone (α-MSH) to target melanoma cells.
Al-Suwayeh, Saleh A. +4 more
core +2 more sources
α-MSH inhibits induction of C/EBPβ-DNA binding activity and NOS2 gene transcription in macrophages [PDF]
, 2000 α-MSH inhibits induction of C/EBPβ-DNA binding activity and NOS2 gene transcription in macrophages.Backgroundα-Melanocyte–stimulating hormone (α-MSH) is an endogenous tridecapeptide that exerts anti-inflammatory actions and abrogates postischemic renal ...
Diaz, Rebecca A. +3 more
core +1 more source
Astrocytes: New Targets of Melanocortin 4 Receptor Actions [PDF]
, 2013 Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss
Carniglia, Lila +4 more
core +1 more source
Nle4DPhe7α-Melanocyte-Stimulating Hormone Increases the Eumelanin:Phaeomelanin Ratio in Cultured Human Melanocytes [PDF]
, 1995 In mammals, melanin exists in two chemically distinct forms: the red-yellow phaeomelanin and the brown-black eumelanin. Although administration of the pigmentary hormone α-melanocyte-stimulating hormone (αMSH) and its synthetic analogue Nle4DPhe7αMSH ...
Hunt, Gillian +4 more
core +1 more source