Results 21 to 30 of about 190,071 (238)

Melanocyte-Stimulating Hormone Receptor

open access: yesDefinitions, 2020
Melanocyte-stimulating hormone receptor (317 aa, ~35 kDa) is encoded by the human MC1R gene. This protein plays a role in both hormone binding and melanogenesis.

semanticscholar   +1 more source

A feasibility and safety study of afamelanotide in acute stroke patients – an open label, proof of concept, phase iia clinical trial

open access: yesBMC Neurology, 2023
Background Neuroprotective agents have the potential to improve the outcomes of revascularisation therapies in acute ischemic stroke patients (AIS) and in those unable to receive revascularisation.
Vimal Stanislaus   +6 more
doaj   +1 more source

Keratinocytes regulate the function of melanocytes

open access: yesDermatologica Sinica, 2014
Mammalian keratinocytes compose the bulk of the epithelium, undergo keratinization, and form the dead superficial layer of the skin. These superficial keratinized cells are continuously replaced by cells derived from mitotic cells in the lowest layer of ...
Tomohisa Hirobe
doaj   +1 more source

Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET

open access: yesTheranostics, 2017
It is estimated that melanoma accounted for 76,380 new cases and 10,130 deaths in the United States in 2016. The melanocortin 1 receptor (MC1R) is highly expressed in the vast majority of melanomas, which makes it an attractive target for molecular ...
Chengcheng Zhang   +7 more
semanticscholar   +1 more source

Development of Radiopharmaceutical Composition for Radionuclide Diagnostics of Malignant Melanoma

open access: yesРазработка и регистрация лекарственных средств, 2020
Introduction. Skin cancers came first in Russia in numbers of oncological diseases. Melanoma, making up only a small part of these cases, leads to the most serious consequences.
O. E. Klementyeva   +6 more
doaj   +1 more source

Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood

open access: yesInternational Journal of Neuropsychopharmacology, 2017
Background Adolescent intermittent ethanol exposure causes long-lasting alterations in brain epigenetic mechanisms. Melanocortin and neuropeptide Y signaling interact and are affected by ethanol exposure in the brain.
D. Kokare   +4 more
semanticscholar   +1 more source

Plasma alpha-melanocyte-stimulating hormone: sex differences and correlations with obesity

open access: yesОжирение и метаболизм, 2010
Metabolism, 2009, Jan.; 58(1): 16 ...

doaj   +1 more source

Effect of 3,6‐anhydro‐l‐galactose on α‐melanocyte stimulating hormone‐induced melanogenesis in human melanocytes and a skin‐equivalent model

open access: yesJournal of Cellular Biochemistry, 2018
3,6‐Anhydro‐l‐galactose (l‐AHG) is a bioactive sugar that is a major component of agarose. Recently, l‐AHG was reported to have anti‐melanogenic potential in human epidermal melanocytes (HEMs) and B16F10 melanoma cells; however, its underlying molecular ...
J. Kim   +4 more
semanticscholar   +1 more source

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

open access: yesMolecular Metabolism, 2016
Objective: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a
Pablo J. Enriori   +23 more
doaj   +1 more source

The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines

open access: yesJournal of experimental & clinical cancer research : CR, 2017
The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by Forskolin (FSK) is also known to enhance melanocyte proliferation.
E. Flori   +6 more
semanticscholar   +1 more source

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